AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST
UPDATE
What are the two types of tobacco found in the wild?
nicotiana sylvestris and nicotiana tomentosifosa
What is the man-made form of tobacco?
nicotiana tabacum
When was tobacco used religiously and medicinally?
10,000 years ago in North and Central America
Where was early tobacco use?
North/Central America; South America (medically); Australia and Indonesia
When did Columbus bring tobacco plants to Europe?
1493
When were the medical properties of tobacco studies? By who?
in the 1500s by Jean Nicot and Nicolas Monardes
When did mainstream tobacco become popular?
early 1600s
Where did cigarettes start?
in Russia during the Crimean war
When did the pushback against tobacco begin?
early 1800s grew to the 1900s
, Which form of nicotine is more potent?
L-nicotine > D-nicotine
What is the primary natural isomer of nicotine?
L-nicotine
What are the characteristics of nicotinic ACh receptors (nAChR)?
ligand-gated ion channel; five subunits (a2-a9, B2-B4, y, S, e); found in CNS and PNS
What are the primary functions of nAChR?
ANS transmission, muscle contraction; involved in ALzheimer's, Parkinson's,
TOurette's, schizophrenia
What is the nicotinic receptor responsible for addiction?
a4B2
What are the effects of nicotine?
release of adrenaline and noradrenaline; increased catecholamines; increased gastric
acid secretion; CMS stimulant; increased respiration; vomiting; overdose
What do the increased catecholamines do?
blood pressure, heart rate
What causes ulcers?
an increase in gastric acid secretion
How does nicotine act as a CNS stimulant?
tremors, blunted emotions, increased concentrations
How does nicotine affect metabolism?
decreased food intake, increased metabolism
How does nicotine affect hormones?