Immunology Practice/ BOC Immunology MLT
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Immune System - ANSWERCan protect against or be manipulated to treat disease
Natural Immunity - ANSWERInnate/Nonspecific; present at birth in all individuals and
is activated in the same manner each time a person is challenged
Adaptive Immunity - ANSWERImmunity that is acquired or learned only after a
challenge is encountered
What are the two types of Adaptive Immunity - ANSWERCell Mediated and Humoral
Cellular Immunity - ANSWERContains Phagocytic cells monocytes, macrophages,
neutrophils, dendritic cells; Also T- Lymphs
Humoral Immunity - ANSWERFluid Soluble constituents such as Complement, Acute
Phase Proteins, and Antibody (B-Lymphs)
Adaptive Immunity:
Passive Natural acquired Immunity - ANSWERPlacental transfer to fetus; breast milk;
duration of response is short term; antibodies not produced by host
Adaptive Immunity:
Passive Artificially acquired Immunity - ANSWERacquired through a transfusion of
sera or plasma; example is Hep B Immunoglobulin (artificial antibody created outside
the body; duration of response is short term; antibodies not produced by host
Adaptive Immunity:
Active Natural Immunity - ANSWERWhen a person is challenged naturally through
infection of a pathogen; example chicken pox; duration of response is long term;
antibodies can be produced by host
Adaptive Immunity:
Active Artificial Immunity - ANSWERVaccine; example Hep B or MMR; duration of
response is long term; antibodies can be produced by host
First Line of Defense - ANSWERUnbroken skin with sebum and lactic acid. normal
bacterial flora that competes with pathogens, secretion such as mucus
Primary Phagocytic cells - ANSWERNeutrophils (PMN) and Mononuclear monocytes-
macrophages
, Neutrophils - ANSWERfunction as a phagoctye they have granules that break down
the cell walls of bacteria they consist of myeloperoxidase, miraminidase, hydrolase
Eosinophils - ANSWERfunction to limit the inflammatory response by releasing
histamines; also play a role in parasitic worm infection with Major Basic Protein
(MBP) which is toxic to integument of worms. Other substances are acid
phosphatase and peroxidase
Basophils - ANSWERFunction to cause the symptoms of allergic reaction; granules
consist of histamine, heparin, and eosinophil chemotatic factor (ECF) which can be
associated with anaphalaxis
Mast Cells - ANSWERPlay a role in hypersensitivity; granules contain acid
phosphatase, alkaline phosphatase, and protease
Monocytes/Macrophages - ANSWERPart of the Mononuclear Phagocytic System
(MPS) function to remove debris and they are antigen presenting cells; their granules
contain lipase which can digest lipid rich cell walls
Dendritic cells - ANSWERfunction as antigen presenting cells they are the most
potent phagocytic cell in the tissues can be called different names because of
location
Langerhans cell-skin mucous membranes
Interstitial-heart, lung, kidney, liver, GI
Interdigitating-secondary lymph tissue and thymus
Lysozyme - ANSWERenzyme with antibacterial activity that attacks cell walls
it if found in tears, saliva, and many cells
Cytokines - ANSWERprotein molecules secreted by leukocytes that transmit
messages to regulate cell growth, differentiation, activity
4 Groups of Cytokines - ANSWERColony Stimulating Factor, tumor necrosis factor,
interleukins, and interferon
Complement - ANSWERnonspecific serum components whose activation results in
cell lysis; overall function is to control inflammation
Acute Phase Proteins (reactants) - ANSWERplay a role in wound healing; hepatic
synthesis of a number of proteins that are released into the blood in large quantities
due to infection, injury, and trauma to tissue
C-Reactive Protein - ANSWERPrimitive nonspecific form of antibody; used as a
indicator of acute inflammation
Serum amyloid A - ANSWERplays a role in metabolism of cholesterol by removing it
from cholesterol-filled macrophages at the site of tissue injury