Test Bank Complete_ Adam's Pharmacology for Nurses:
A Pathophysiologic Approach, 7th Edition, (2024) By
Michael Adams, Norman Holland & Shanti Chang All
Chapters 1-50| Nine Units| All Answers With Complete
Explanations in all Choices
gated open pores in the cytoplasmic membrane that regulate entry of calcium ions
into cells - ANSWERCalcium channels
Calcium entry plays a critical role in the entry of what? - ANSWERthe function of
vascular smooth muscle (VSM) and the heart
In vascular smooth muscle, calcium channels regulate through what? -
ANSWERcontraction
What initiates the contractile process in VSM? - ANSWERAn action potential travels
down the surface of a smooth muscle cell, calcium channels open and calcium ions
flow inward
What happens when calcium channels are blocked in VSM? - ANSWERVasodilation
will result
Do CCBs have an effect on the veins? - ANSWERNo
CCBs act __________ on peripheral arterioles and arteries and arterioles of the heart
- ANSWERselectively
In the heart, what do calcium channels help to regulate? - ANSWERThe myocardium,
SA node, and AV node
Calcium channels at their three sites in the heart are coupled to what receptors -
ANSWERBeta1 adrenergic
In cardiac muscle, calcium entry have a positive or negative inotropic effect -
ANSWERpositive
Contractile force will diminish if calcium channels in the ________ and
____________ muscles are blocked - ANSWERatrial and ventricular
What regulates the pacemaker activity of the SA node? - ANSWERcalcium influx
Does the discharge of the SA node increase or decrease when calcium channels are
open? - ANSWERincrease
The effect of calcium channel blockade (in SA node) is to - ANSWERreduce heart rate
, Regulation of _____________ plays a critical role in coordinating contraction of the
ventricles with contraction of the atria - ANSWERAV conduction
The excitability of AV nodal cells is regulated by what? - ANSWERcalcium entry
The effect of calcium channel blockade (in AV node) is to - ANSWERDecrease velocity
of conduction through the AV node
What similarities to beta blockers and CCBs have? - ANSWERthey have identical
effects on the heart
- reduce force of contraction
- slow heart rate
- suppress conduction through AV node
Nifedipine is the prototype of which CCB family - ANSWERdihydropyridines
What is the only phenylalkylamine? - ANSWERverapamil
what is the only benzothiazepine - ANSWERdilitiazem
What calcium channel blocker affects the heart and blood vessels? -
ANSWERVerapamil and diltiazem
What CCB acts mainly on blood vessels? - ANSWERNifedipine
What two dihydropyridines can help with migraines? - ANSWERNifedipine and
Nimodipine
What three dihydropyridines can help with angina? - ANSWERNifedipine,
amlodipine, Nicardipine
Verapamil and Diltiazem may be indicated for what conditions? - ANSWERHTN
Angina
Dysrhythmias
Migraine
All CCBs are indicated for what? - ANSWERHTN
What are the 5 direct effects Verapamil has on the heart/blood vessels? -
ANSWERBlockade at:
1) peripheral arterioles causes dilation and thereby reduces arterial pressure
2) arteries and arterioles of the heart increases coronary perfusion
3) the SA node reduces heart rate
4) AV node decreases AV nodal conduction
5) in the myocardium decreases force of contraction
A Pathophysiologic Approach, 7th Edition, (2024) By
Michael Adams, Norman Holland & Shanti Chang All
Chapters 1-50| Nine Units| All Answers With Complete
Explanations in all Choices
gated open pores in the cytoplasmic membrane that regulate entry of calcium ions
into cells - ANSWERCalcium channels
Calcium entry plays a critical role in the entry of what? - ANSWERthe function of
vascular smooth muscle (VSM) and the heart
In vascular smooth muscle, calcium channels regulate through what? -
ANSWERcontraction
What initiates the contractile process in VSM? - ANSWERAn action potential travels
down the surface of a smooth muscle cell, calcium channels open and calcium ions
flow inward
What happens when calcium channels are blocked in VSM? - ANSWERVasodilation
will result
Do CCBs have an effect on the veins? - ANSWERNo
CCBs act __________ on peripheral arterioles and arteries and arterioles of the heart
- ANSWERselectively
In the heart, what do calcium channels help to regulate? - ANSWERThe myocardium,
SA node, and AV node
Calcium channels at their three sites in the heart are coupled to what receptors -
ANSWERBeta1 adrenergic
In cardiac muscle, calcium entry have a positive or negative inotropic effect -
ANSWERpositive
Contractile force will diminish if calcium channels in the ________ and
____________ muscles are blocked - ANSWERatrial and ventricular
What regulates the pacemaker activity of the SA node? - ANSWERcalcium influx
Does the discharge of the SA node increase or decrease when calcium channels are
open? - ANSWERincrease
The effect of calcium channel blockade (in SA node) is to - ANSWERreduce heart rate
, Regulation of _____________ plays a critical role in coordinating contraction of the
ventricles with contraction of the atria - ANSWERAV conduction
The excitability of AV nodal cells is regulated by what? - ANSWERcalcium entry
The effect of calcium channel blockade (in AV node) is to - ANSWERDecrease velocity
of conduction through the AV node
What similarities to beta blockers and CCBs have? - ANSWERthey have identical
effects on the heart
- reduce force of contraction
- slow heart rate
- suppress conduction through AV node
Nifedipine is the prototype of which CCB family - ANSWERdihydropyridines
What is the only phenylalkylamine? - ANSWERverapamil
what is the only benzothiazepine - ANSWERdilitiazem
What calcium channel blocker affects the heart and blood vessels? -
ANSWERVerapamil and diltiazem
What CCB acts mainly on blood vessels? - ANSWERNifedipine
What two dihydropyridines can help with migraines? - ANSWERNifedipine and
Nimodipine
What three dihydropyridines can help with angina? - ANSWERNifedipine,
amlodipine, Nicardipine
Verapamil and Diltiazem may be indicated for what conditions? - ANSWERHTN
Angina
Dysrhythmias
Migraine
All CCBs are indicated for what? - ANSWERHTN
What are the 5 direct effects Verapamil has on the heart/blood vessels? -
ANSWERBlockade at:
1) peripheral arterioles causes dilation and thereby reduces arterial pressure
2) arteries and arterioles of the heart increases coronary perfusion
3) the SA node reduces heart rate
4) AV node decreases AV nodal conduction
5) in the myocardium decreases force of contraction
