Cardiac Labs
1. what is troponin used for?: highly sensitive and specific lab for cardiac
damage (MI)
2. when does change in serum troponin occur after the onset of chest
pain?-
: increases within 2-3
hours peaks at 12-24
hours
3. what is the downside of using troponin to detect MI?: may not be
detectable for the first 6 hours after the onset of cell injury
4. what is required to diagnose MI?: evidence of acute myocardial injury &
clinical evidence of ischemia
5. what is the preferred blood test to evaluate for MI?: troponin
6. when should troponin be ordered?: at presentation and ~2 hours later,
then 6 and 12 hours later, depending on if level is still rising
7. what is delta change?: the change in troponin concentration between
two as- says performed at a prespecified time interval appart
8. why can troponin be elevated in cases that are not MI?: CHF, sepsis,
acute PE, CKD, myocarditis, aortic aneurysms
9. what is creatinine kinase (CK)?: cardiac enzyme known to be released
during muscle necrosis (including cardiac muscle cell death)
10.what are the isoenzymes of CK?: MM: striated
muscle BB: brain, prostate, lungs, GI
MB: heart
11.what is the specificity and sensitivity of myocardial muscle
creatinine kinase (CK-MB)?: >97%, still not as high as troponin
12.when is CK-MB used?: to detect early reinfarction
13.what is myoglobin?: a heme protein that stores oxygen and is rapidly
released from damaged muscle cells
14.is myoglobin specific for cardiac disease?: no
15.when does myoglobin elevate?: 1-2 hours after an acute MI
16.what is aspartate aminotransferase (AST)?: an enzyme that is
elevated in liver, heart, and skeletal muscle
can be used as a biomarker to aid in the diagnosis of an acute MI
17.what is lactate dehydrogenase?: an enzyme that increases about 6-12
hours after an MI
18.when is lactate dehydrogenase used?: to differentiate between
acute and subacute MI
19.what is brain natriuretic peptide (BNP)?: a hormone that is released
from the ventricular myocardium as a result of volume and pressure
1/
1. what is troponin used for?: highly sensitive and specific lab for cardiac
damage (MI)
2. when does change in serum troponin occur after the onset of chest
pain?-
: increases within 2-3
hours peaks at 12-24
hours
3. what is the downside of using troponin to detect MI?: may not be
detectable for the first 6 hours after the onset of cell injury
4. what is required to diagnose MI?: evidence of acute myocardial injury &
clinical evidence of ischemia
5. what is the preferred blood test to evaluate for MI?: troponin
6. when should troponin be ordered?: at presentation and ~2 hours later,
then 6 and 12 hours later, depending on if level is still rising
7. what is delta change?: the change in troponin concentration between
two as- says performed at a prespecified time interval appart
8. why can troponin be elevated in cases that are not MI?: CHF, sepsis,
acute PE, CKD, myocarditis, aortic aneurysms
9. what is creatinine kinase (CK)?: cardiac enzyme known to be released
during muscle necrosis (including cardiac muscle cell death)
10.what are the isoenzymes of CK?: MM: striated
muscle BB: brain, prostate, lungs, GI
MB: heart
11.what is the specificity and sensitivity of myocardial muscle
creatinine kinase (CK-MB)?: >97%, still not as high as troponin
12.when is CK-MB used?: to detect early reinfarction
13.what is myoglobin?: a heme protein that stores oxygen and is rapidly
released from damaged muscle cells
14.is myoglobin specific for cardiac disease?: no
15.when does myoglobin elevate?: 1-2 hours after an acute MI
16.what is aspartate aminotransferase (AST)?: an enzyme that is
elevated in liver, heart, and skeletal muscle
can be used as a biomarker to aid in the diagnosis of an acute MI
17.what is lactate dehydrogenase?: an enzyme that increases about 6-12
hours after an MI
18.when is lactate dehydrogenase used?: to differentiate between
acute and subacute MI
19.what is brain natriuretic peptide (BNP)?: a hormone that is released
from the ventricular myocardium as a result of volume and pressure
1/
