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xHow do penicillins and cephalosporins work? - Correct answer.weaken cell wall and promote lysis and
cell death
Bactericidal drugs are: - Correct answer.are directly lethal to bacteria at achievable concentrations
Why are narrow spectrum antibiotics preferred over broad spectrum antibiotics? - Correct answer.Broad
spectrum antibiotics do the most to facilitate emergence of resistance
How does bacterial resistance develop with penicillins? - Correct answer.production of penicillin binding
proteins that have *low affinity* for penicillins
inability of penicillins to reach their target
inactivation of penicillins by bacterial enzymes
Strep throat treatment with PCN allergy? - Correct answer.Azithromycin
What are penicillinases? - Correct answer.beta-lactamases that act selectively on penicillins
List penicillinase-resistant penicillin: - Correct answer.Nafcillin
Dicloxacillin
Oxacillin
, Broad spectrum penicillin? - Correct answer.Amoxicillin
Ampicillin
Extended spectrum penicillin? - Correct answer.Piperacillin
Beta-lactamase inhibitors? - Correct answer.Clavulanic acid
Sulbactam
Tazobactam
Cephalosporins you should not give to alcoholics? - Correct answer.Cefazolin
cefmetazole
cefoperazone
cefotetan
What is first generation cephalosporins used for? - Correct answer.Surgical prophylaxis
Cefadroxil
Cephalexin
What cephalosporin should people on coumadin avoid? - Correct answer.cefotetan
ceftriaxone
cefmetazole
cefoperazone
*decrease prothrombin, interferes with vit. k*
3rd Generation cephalosporins treat? - Correct answer.meningitis
*can penetrate spinal fluid*
4th Generation cephalosporins treat? - Correct answer.upper resp tract infections:
pneumonia