Neurophysiology Exam 3: Ch 23 with
Complete Solutions 2025
a mutation in TrkA receptor gene would affect signaling of which neurotrophin -
ANSWER-NGF
a mutation in which gene would lead to abnormalities in spacing of dendritic branches? -
ANSWER-DSCAM
actin and tubulin dynamics in growth cones are influenced or regulated by - ANSWER-
TRP channels
actin cytoskeleton - ANSWER-regulates changes in lamellipodial and filopodial shape
for directed growth
anosmic - ANSWER-relating to loss of sense of smell
apoptosis - ANSWER-highly regulated process that result in cell death, is mediated by a
specific group of neurotrophic factors (neurotrophins)
basal lamina - ANSWER-organized sheets of ECM provide a supportive substrate
BDNF (brain-derived neurotrophic factor) - ANSWER-promotes dendritic growth
Brain-derived neurotrophic factor (BDNF) - ANSWER-a protein in the nervous system
that promotes survival, growth, and the formation of new synapses
-I.e. merkel's disk
Ca2+-dependent adhesion molecules or Cadherins - ANSWER-are also capable of
homophilic binding, they signal via activation of beta catenin, which influences gene
expression
CAMs and cadherins - ANSWER-found on growth cones and growing axons as well as
surrounding cells and targets. have dual functions as ligands and receptors via
homophilic binding
chemoaffinity hypothesis - ANSWER-explains how topographic maps arise during
development. terminals of retinal ganglion cells form a precise topographic map in the
optic tectum. retinal axons that had been crushed reestablish the original topographic
pattern in the tectem. each tectal cell carries a chemical "identification tag" and that the
growing terminals of retinal ganglion cells have a complimentary tag
chemoattractants and chemorepellants - ANSWER-tropic, signals that can direct growth
from a distance
, attract (+): often act on a pioneer growth cone that sets out a course distinct from that of
the fasciculated followers, similar cues acting on or near the surface of the axon shaft
help maintain groups of axons as fascicles, which is essential for the formation of
coherent nerves and tracts.
repel (-): act on regions where axons must defasciculate from nascent nerve in order to
change their trajectory or avoid an inappropriate target.
Chemoattraction - ANSWER-growth of axons towards sources of diffusible attractive
molecules
Chemorepulsion - ANSWER-turning or directing of axons away from sources of
diffusible repulsive molecules
Collagen - ANSWER-A glycoprotein in the extracellular matrix of animal cells that forms
strong fibers, found extensively in connective tissue and bone; the most abundant
protein in the animal kingdom.
convergence - ANSWER-regulates the number of inputs to a target cells
DCC - ANSWER-deleted in colorectal cancer, a netrin receptor
DCC - ANSWER-Deleted in Colorectal Carcinoma (receptor for netrin-1). DCC gene
product can induce apoptosis via a mitochondria-independent pathway
-specific receptors that transduce netrin chemoattractant
dendritic polarization - ANSWER-essential for appropriate circuit function, underlie their
unique information-processing capacity
dendritic tiling - ANSWER-dendritic avoidance of separate neurons
dendritic tiling - ANSWER-proper modulation of dendritic growth so that each dendritic
arbor occupies appropriate space to accommodate incoming axons that will synapse on
it
-regulation of dendrites so they don't grow towards nearby dendrites
-developing dendrites from different neurons repellants from one another to ensure that
each dendritic arbor provides adequate coverage for a particular region of neuronal
space.
divergence - ANSWER-regulates the number of connections made by a neuron
DSCAM1 - ANSWER-close relative of DSCAM2, has remarkable genomic structure,
has multiple splice acceptor and donor sites distributed over four exons.
DSCAM1 - ANSWER-proteins, homophilic interactions create repulsive cues
-prevent branches of the same neuron from growing on top of one another
Complete Solutions 2025
a mutation in TrkA receptor gene would affect signaling of which neurotrophin -
ANSWER-NGF
a mutation in which gene would lead to abnormalities in spacing of dendritic branches? -
ANSWER-DSCAM
actin and tubulin dynamics in growth cones are influenced or regulated by - ANSWER-
TRP channels
actin cytoskeleton - ANSWER-regulates changes in lamellipodial and filopodial shape
for directed growth
anosmic - ANSWER-relating to loss of sense of smell
apoptosis - ANSWER-highly regulated process that result in cell death, is mediated by a
specific group of neurotrophic factors (neurotrophins)
basal lamina - ANSWER-organized sheets of ECM provide a supportive substrate
BDNF (brain-derived neurotrophic factor) - ANSWER-promotes dendritic growth
Brain-derived neurotrophic factor (BDNF) - ANSWER-a protein in the nervous system
that promotes survival, growth, and the formation of new synapses
-I.e. merkel's disk
Ca2+-dependent adhesion molecules or Cadherins - ANSWER-are also capable of
homophilic binding, they signal via activation of beta catenin, which influences gene
expression
CAMs and cadherins - ANSWER-found on growth cones and growing axons as well as
surrounding cells and targets. have dual functions as ligands and receptors via
homophilic binding
chemoaffinity hypothesis - ANSWER-explains how topographic maps arise during
development. terminals of retinal ganglion cells form a precise topographic map in the
optic tectum. retinal axons that had been crushed reestablish the original topographic
pattern in the tectem. each tectal cell carries a chemical "identification tag" and that the
growing terminals of retinal ganglion cells have a complimentary tag
chemoattractants and chemorepellants - ANSWER-tropic, signals that can direct growth
from a distance
, attract (+): often act on a pioneer growth cone that sets out a course distinct from that of
the fasciculated followers, similar cues acting on or near the surface of the axon shaft
help maintain groups of axons as fascicles, which is essential for the formation of
coherent nerves and tracts.
repel (-): act on regions where axons must defasciculate from nascent nerve in order to
change their trajectory or avoid an inappropriate target.
Chemoattraction - ANSWER-growth of axons towards sources of diffusible attractive
molecules
Chemorepulsion - ANSWER-turning or directing of axons away from sources of
diffusible repulsive molecules
Collagen - ANSWER-A glycoprotein in the extracellular matrix of animal cells that forms
strong fibers, found extensively in connective tissue and bone; the most abundant
protein in the animal kingdom.
convergence - ANSWER-regulates the number of inputs to a target cells
DCC - ANSWER-deleted in colorectal cancer, a netrin receptor
DCC - ANSWER-Deleted in Colorectal Carcinoma (receptor for netrin-1). DCC gene
product can induce apoptosis via a mitochondria-independent pathway
-specific receptors that transduce netrin chemoattractant
dendritic polarization - ANSWER-essential for appropriate circuit function, underlie their
unique information-processing capacity
dendritic tiling - ANSWER-dendritic avoidance of separate neurons
dendritic tiling - ANSWER-proper modulation of dendritic growth so that each dendritic
arbor occupies appropriate space to accommodate incoming axons that will synapse on
it
-regulation of dendrites so they don't grow towards nearby dendrites
-developing dendrites from different neurons repellants from one another to ensure that
each dendritic arbor provides adequate coverage for a particular region of neuronal
space.
divergence - ANSWER-regulates the number of connections made by a neuron
DSCAM1 - ANSWER-close relative of DSCAM2, has remarkable genomic structure,
has multiple splice acceptor and donor sites distributed over four exons.
DSCAM1 - ANSWER-proteins, homophilic interactions create repulsive cues
-prevent branches of the same neuron from growing on top of one another
