FRSC 2600- TOXICOLOGY EXAM QUESTIONS AND ANSWERS
WITH COMPLETE SOLUTIONS VERIFIED
Toxicology
the study of the adverse effects of chemicals or physical agents on living organisms
What are the types of toxicology?
Environmental, Consumer, and Medical/Clinical/Forensic
Environmental
Air, Water, and Soil
Consumer
Food, Cosmetics, and Drugs
When can toxicology be performed?
Postmortem, Criminally, Workplace, Sports
Why is doing toxicology important?
because it could be a:
1. cause of death
2. contribute to death
3. cause impairment
4. explain behavior
Who is John Metzger and what is he known for?
discovered a way to detect arsenic (1787)
, Who is Valentine Rose and what is she known for?
showed how arsenic could be detected in human organs (1806)
Who is Methieu Orfila and what is he known for?
published his work "Traite des Posions" which described the first systematic approach
to the study of chemistry and physiological nature of poisons.
Who is Thomas Hickey and what is he known for?
the first American executed for treason for attempting to poison George Washington in
1776
Ideally, a good poison should be
Odorless, tasteless, colorless, soluble, delayed onset of action, undetectable, low-dose
lethality, easily obtainable, not traceable, chemically stable, mimics a natural disease.
Effects of poisons
CNS depression, respiratory arrest, cardiovascular effects, specific bodily functions
What is L50?
the lethal dose expressed in milligrams of substance per kilogram of body weight
Potency
sensitivity of an organ or tissue to a drug and/or the measure of dose
Efficacy
the maximum effect of a drug and/or the measure of quantified drug response
Aspects of Toxicity
dosage, the chemical or physical form of the substance, the mode of entry into the
body, body weight and physiological conditions of the victim (including age an sex), the
time period of exposure, the presence of other chemicals in the body or in the dose
WITH COMPLETE SOLUTIONS VERIFIED
Toxicology
the study of the adverse effects of chemicals or physical agents on living organisms
What are the types of toxicology?
Environmental, Consumer, and Medical/Clinical/Forensic
Environmental
Air, Water, and Soil
Consumer
Food, Cosmetics, and Drugs
When can toxicology be performed?
Postmortem, Criminally, Workplace, Sports
Why is doing toxicology important?
because it could be a:
1. cause of death
2. contribute to death
3. cause impairment
4. explain behavior
Who is John Metzger and what is he known for?
discovered a way to detect arsenic (1787)
, Who is Valentine Rose and what is she known for?
showed how arsenic could be detected in human organs (1806)
Who is Methieu Orfila and what is he known for?
published his work "Traite des Posions" which described the first systematic approach
to the study of chemistry and physiological nature of poisons.
Who is Thomas Hickey and what is he known for?
the first American executed for treason for attempting to poison George Washington in
1776
Ideally, a good poison should be
Odorless, tasteless, colorless, soluble, delayed onset of action, undetectable, low-dose
lethality, easily obtainable, not traceable, chemically stable, mimics a natural disease.
Effects of poisons
CNS depression, respiratory arrest, cardiovascular effects, specific bodily functions
What is L50?
the lethal dose expressed in milligrams of substance per kilogram of body weight
Potency
sensitivity of an organ or tissue to a drug and/or the measure of dose
Efficacy
the maximum effect of a drug and/or the measure of quantified drug response
Aspects of Toxicity
dosage, the chemical or physical form of the substance, the mode of entry into the
body, body weight and physiological conditions of the victim (including age an sex), the
time period of exposure, the presence of other chemicals in the body or in the dose
