AOCNP EXAM QUESTIONS AND CORRECT
ANSWERS
the risk for significant bone marrow suppression (8) - ANSWER>>advanced age
(>65),poor nutritional status, preexisting autoimmune disease, DM, GI
disorders, liver disease, or hematopoietic disease, and substance abuse.
Cancer-induced bone marrow suppression (3) - ANSWER>>a) dysfunctional
hematopoietic cell within the bone marrow, b) bone marrow infiltration with
tumor c)general exhaustion of bone marrow reserves
solid tumor malignancies with the highest propensity to infiltrate the bone
marrow in the course of metastasis - ANSWER>>melanoma, cancer of the
breast, lung, kidney and prostate
Nitrosoureas (Carmustine, Lomustine) - ANSWER>>affect the pluripotent stem
cell (affecting all cell lines/cell cycle nonspecific agent) use for glioblastoma
multiforme
severe myelosuppression may last up to 85 days, nadir of carmustine occurs in
26-60 days
Radiation induced bone marrow suppression occurs when (2) - ANSWER>>1.
treatment field involves marrow producing tissue or with dose greater than 15
Gy
CD 4 counts < 500/mm3 - ANSWER>>significant risk factor for oopotunisitic
infections
Cyclosphosphamide - myelosuppression risk - ANSWER>>moderate
Paclitaxel - myelosuppression risk - ANSWER>>moderate
,Doxorubicin (Adriamycin) - myelosuppression risk - ANSWER>>alkylating agnet,
may produce severe myelosuppression, the duration only about 21 days
Myelosupression secondary to radiation therapy peaks at - ANSWER>>week 3
Suppression may occur in all cell lines simultaneously rather than sequentially
as seen with chemotherapy
The recovery period also may be less predictable.
Second malignancy : Acute leukemia - potential etiologic factor ? -
ANSWER>>Alkylating agent, especially with high doses or cumulative doses of
antimetabolites
Antitumor antibiotics
Corticosteroids
Epipodophyllotoxins (i.e Etoposide)
Second malignancy : Bladder cancer- potential etiologic factor ? -
ANSWER>>radiation therapy for prostate cancer
Second malignancy : Brain tumors - potential etiologic factor ? -
ANSWER>>therapeutic radiation for other cancer
Second malignancy : hepatoma- potential etiologic factor ? -
ANSWER>>Androgen therapy
Second malignancy : Kidney cancer - potential etiologic factor ? -
ANSWER>>Brain tumor therapies
Cisplatin, especially in treatment for testicular cancer
Second malignancy : Leukemia - potential etiologic factor ? -
ANSWER>>Antitumor antibiotics
Brest cancer treatment
Lymphoma treatment
, Post transplant immunosuppression
Prostate cancer treatment
Second malignancy : Lung cancer - potential etiologic factor ? - ANSWER>>HIV
infection
Theraputic radiation for other cancers
Second malignancy : Mesothelioma - potential etiologic factor ? -
ANSWER>>Thoracic radiation for lung neoplasms
Second malignancy : Neuroectodermal tumors- potential etiologic factor ? -
ANSWER>>Growth hormone replacement after children cancers
Theraputic radiation for other cancers
Second malignancy : Non-Hodgkin Lymphoma- potential etiologic factor ? -
ANSWER>>Alkylating agent
Antimetabolites
Antitumor antibiotics
Cyclosporine
Radiation therapy
Tacrolimus
Cumulative radiation dose in excess of ___ Gy reporrted have more signifiant
risk of secondary malignancies - ANSWER>>30 Gy
Second malignancy : Thyroid cancer- potential etiologic factor ? -
ANSWER>>Brain tumor therapies
Cisplatin based regimens
Therapeutic radiation
In a patient with an abnormal complete blood count with all cell line diminished
and without evidence for a specific disorder and in whom an eorror in cell
ANSWERS
the risk for significant bone marrow suppression (8) - ANSWER>>advanced age
(>65),poor nutritional status, preexisting autoimmune disease, DM, GI
disorders, liver disease, or hematopoietic disease, and substance abuse.
Cancer-induced bone marrow suppression (3) - ANSWER>>a) dysfunctional
hematopoietic cell within the bone marrow, b) bone marrow infiltration with
tumor c)general exhaustion of bone marrow reserves
solid tumor malignancies with the highest propensity to infiltrate the bone
marrow in the course of metastasis - ANSWER>>melanoma, cancer of the
breast, lung, kidney and prostate
Nitrosoureas (Carmustine, Lomustine) - ANSWER>>affect the pluripotent stem
cell (affecting all cell lines/cell cycle nonspecific agent) use for glioblastoma
multiforme
severe myelosuppression may last up to 85 days, nadir of carmustine occurs in
26-60 days
Radiation induced bone marrow suppression occurs when (2) - ANSWER>>1.
treatment field involves marrow producing tissue or with dose greater than 15
Gy
CD 4 counts < 500/mm3 - ANSWER>>significant risk factor for oopotunisitic
infections
Cyclosphosphamide - myelosuppression risk - ANSWER>>moderate
Paclitaxel - myelosuppression risk - ANSWER>>moderate
,Doxorubicin (Adriamycin) - myelosuppression risk - ANSWER>>alkylating agnet,
may produce severe myelosuppression, the duration only about 21 days
Myelosupression secondary to radiation therapy peaks at - ANSWER>>week 3
Suppression may occur in all cell lines simultaneously rather than sequentially
as seen with chemotherapy
The recovery period also may be less predictable.
Second malignancy : Acute leukemia - potential etiologic factor ? -
ANSWER>>Alkylating agent, especially with high doses or cumulative doses of
antimetabolites
Antitumor antibiotics
Corticosteroids
Epipodophyllotoxins (i.e Etoposide)
Second malignancy : Bladder cancer- potential etiologic factor ? -
ANSWER>>radiation therapy for prostate cancer
Second malignancy : Brain tumors - potential etiologic factor ? -
ANSWER>>therapeutic radiation for other cancer
Second malignancy : hepatoma- potential etiologic factor ? -
ANSWER>>Androgen therapy
Second malignancy : Kidney cancer - potential etiologic factor ? -
ANSWER>>Brain tumor therapies
Cisplatin, especially in treatment for testicular cancer
Second malignancy : Leukemia - potential etiologic factor ? -
ANSWER>>Antitumor antibiotics
Brest cancer treatment
Lymphoma treatment
, Post transplant immunosuppression
Prostate cancer treatment
Second malignancy : Lung cancer - potential etiologic factor ? - ANSWER>>HIV
infection
Theraputic radiation for other cancers
Second malignancy : Mesothelioma - potential etiologic factor ? -
ANSWER>>Thoracic radiation for lung neoplasms
Second malignancy : Neuroectodermal tumors- potential etiologic factor ? -
ANSWER>>Growth hormone replacement after children cancers
Theraputic radiation for other cancers
Second malignancy : Non-Hodgkin Lymphoma- potential etiologic factor ? -
ANSWER>>Alkylating agent
Antimetabolites
Antitumor antibiotics
Cyclosporine
Radiation therapy
Tacrolimus
Cumulative radiation dose in excess of ___ Gy reporrted have more signifiant
risk of secondary malignancies - ANSWER>>30 Gy
Second malignancy : Thyroid cancer- potential etiologic factor ? -
ANSWER>>Brain tumor therapies
Cisplatin based regimens
Therapeutic radiation
In a patient with an abnormal complete blood count with all cell line diminished
and without evidence for a specific disorder and in whom an eorror in cell
