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Corticotropin-releasing hormone (CRH)
From the placenta and fetus
Increased CRH stimulated fetal HPA axis, promoting increased cortisol and estrogen.
Induced production of pro inflammatory factors
Enhances uterine response to prostaglandins and oxytocin
Quinescence (Phase 0)
Late period of pregnancy, before labor begins
Inhibitors of labor
Progesterone
Nitric oxide
Relaxin
Prostacyclin
Activation (Phase 1)
Uterotropins
, Hormones that prepare the uterus to contract
Estrogen
Prostaglandins
Stimulation (Phase 2)
Uterotonins
Hormones that cause uterine contractions and promote labor progression.
Oxytocin
Prostaglandins
Involution (Phase 3)
Involution after birth is mediated by oxytocin, prostaglandin and thrombin
Gap junctions
Allow communication between muscle fibers that allows for effective coordination of
contractions.
Needed for both onset and effective progress of labor
Myometrium
Smooth muscle tissue of the uterus
Middle muscular layer
Myometrium contraction
Rhythmic contractions which result in "endometrial waves" in the non pregnant uterus,
braxton hicks contractions and true labor contractions
Myometrial activity during activation
When PGE, prostacyclin, relaxin, and nitric oxide cease = increase in uterine activity
ensues