Test Bank for Pharmacotherapeutics for Nurse Practitioner
d d d d d d
Prescribers d
Latest edtion d
Charles R. Drew University of Medicine and Science
d d d d d d d
Chapterd 1:d Thed Roledofd thed Nursed Practitionerdasd Prescriber
Multipled Choice
Identifyd thedchoicedthatdbestdcompletesdthedstatementdordanswersdthedquestion.
_ 1.d Nursedpractitionerd prescriptived authorityd isdregulatedd by:
A. Thed Nationald Councild ofdStatedBoardsdofdNursing
B. Thed U.S.dDrugd Enforcementd Administration
C. Thed StatedBoarddofdNursingd ford eachdstate
D. Thed StatedBoarddofdPharmacy
_ 2.d Physiciand Assistantd (PA)dprescriptived authorityd isdregulatedd by:
A. Thed Nationald Councild ofdStatedBoardsdofdNursing
B. Thed U.S.dDrugd Enforcementd Administration
C. Thed Stated Boardd ofdNursing
D. Thed StatedBoarddofdMedicald Examiners
_ 3.dClinicald judgmentd indprescribingd includes:
A. Factoringd ind thedcostdtodthedpatientd ofdthed medicationd prescribed
B. Alwaysd prescribingd thednewestdmedicationd availabled fordtheddiseasedprocess
C. Handingd outd drugdsamplesd todpoordpatients
D. Prescribingd alldgenericd medicationsd todcutdcosts
_ 4.d Criteriad fordchoosingd andeffectived drugd fordaddisorderdinclude:
A. Askingd thedpatientd whatddrugdtheydthinkd wouldd workdbestdfordthem
B. Consultingdnationallydrecognizedd guidelinesd forddiseasedmanagement
C. Prescribingd medicationsdthatd aredavailabledasdsamplesd befored writingd adprescription
D. Followingd U.S.dDrugd Enforcementd Administrationd (DEA)dguidelinesd ford
prescribing
_ 5.d Nursedpractitionerd practiced maydthrived underdhealth-cared reformdduedto:
A. Theddemonstrateddabilitydofdnursedpractitionersdtodcontroldcostsdanddimprovedpatientdo
utcomes
B. Thedfactdthatdnursed practitionersd willdbedabledtodpracticedindependently
C. Thedfactdthatdnursedpractitionersdwilldhavedfulldreimbursementdunderdhealth-
caredreform
D. Thed abilityd todshiftd accountabilityd fordMedicaidd todthed statedlevel
,Chapterd 1:d Thed Roledofd thed Nursed Practitionerdasd PrescriberdAnswe
rd Section
MULTIPLEd CHOICE
1. ANS:d C PTS:ddd 1
2. ANS:d D PTS:ddd 1
3. ANS:d A PTS:ddd 1
4. ANS:d B PTS:ddd 1
5. ANS:d A PTS:ddd 1
Chapterd 2:d Reviewd ofd Basicd Principlesd ofdPharmacology
Multipled Choice
Identifyd thedchoicedthatdbestdcompletesdthedstatementdordanswersdthedquestion.
_
1.d Adpatient’sd nutritionald intaked anddlabdworkdreflectsd hypoalbuminemia.d Thisd is
dcriticald todprescribingd because:
A. Distributiond ofddrugsd todtargetdtissued maydbedaffected
B. Thed solubilityd ofdtheddrugd willd notdmatchd thed sited ofdabsorption
C. Thered willd bedlessd freed drugd availabledtodgenerated andeffect
D. Drugsd bounddtodalbumind aredreadilyd excretedd bydthed kidney
_ 2.d Drugsd thatd haved adsignificantd first-passd effect:
A. Mustdbedgivend bydthedenterald (oral)d routed only
B. Bypassdthedhepaticdcirculation
C. Aredrapidlyd metabolizedd bydthedliverd andd maydhaved littled ifdanyd desiredd action
D. Aredconvertedd bydthed liverd todmored actived anddfat-solubled forms
_ 3.d Thed routed ofdexcretiond ofdadvolatiled drugdwilld likelyd be:
A. Thedkidneys
B. Thedlungs
C. Thedbiledanddfeces
D. Thedskin
_
4.dMedroxyprogesteroned(DepodProvera)disdprescribeddIMdtodcreatedadstoragedrese
rvoirdofdtheddrug.d Storaged reservoirs:
A. Assuredthatdtheddrugdwilld reachditsdintendedd targetd tissue
B. Aredthedreasondfordgivingd loadingd doses
C. Increased thed lengthdofdtimed addrugdisd availabled anddactive
D. Aredmostdcommond indcollagend tissues
_ 5.d Thed NPdchoosesd todgived cephalexind everyd 8dhoursd baseddondknowledged ofd thed drug’s:
A. Propensityd todgodtodthed targetd receptor
B. Biologicaldhalf-life
C. Pharmacodynamics
D. Safetydanddsidedeffects
_
6.dAzithromycinddosingdrequiresdthedfirstdday’sddosedbedtwicedthosedofdthedotherd4dd
aysdofdthedprescription.dThisd isd consideredd adloadingd dose.dAdloadingd dose:
A. Rapidlyd achievesd drugdlevelsd indthedtherapeuticd range
B. Requiresd fourd todfived half-livesd todattain
, C. Isdinfluenceddbydrenald function
D. Isddirectlyd relatedd todthed drugdcirculatingd todthed targetdtissues
_
7.dThedpointdindtimedondtheddrugdconcentrationdcurvedthatdindicatesdthedfirstdsigndofda
therapeuticdeffectd isd the:
d
A. Minimumdadversedeffectdlevel
B. Peakdofdaction
C. Onsetdofdaction
D. Therapeuticdrange
_ 8.d Phenytoind requiresd adtroughdleveld beddrawn.dPeakdanddtroughd levelsd areddone:
A. Whendtheddrugdhasdadwidedtherapeuticd range
B. Whendthed drugdwilld bedadministereddfordadshortd timed only
C. Whendthered isd adhighd correlationd betweendthed dosedanddsaturationd ofdreceptordsites
D. Toddeterminedifd addrugdisd indthed therapeuticd range
_
9.d Adlaboratorydresultd indicatesd thedpeakdleveld fordaddrugd isdaboved thedmini
mumd toxicdconcentration.d Thisd meansd thatd the:
A. Concentrationd willd producedtherapeuticd effects
B. Concentrationd willd producedandadversedresponse
C. Timed betweenddosesdmustd bedshortened
D. Durationd ofdactiond ofdtheddrugd isdtoodlong
_ 10.d Drugsdthatdaredreceptordagonistsd mayddemonstrated whatd property?
A. Irreversibled bindingd todthed drugdreceptordsite
B. Up-regulationdwithdchronicduse
C. Desensitizationd orddown-regulationd withd continuousduse
D. Inversedrelationshipd betweenddrugdconcentrationd andddrugdaction
_ 11.d Drugsd thatd aredreceptordantagonists,d suchdasdbetadblockers,d maydcause:
A. Down-regulationd ofdtheddrugdreceptor
B. Andexaggeratedd responsedifdabruptlyddiscontinued
C. Partiald blockaded ofdthedeffectsd ofdagonistddrugs
D. Andexaggeratedd responsed todcompetitived drugdagonists
_ 12.d Factorsdthatdaffectd gastricd drugdabsorptiondinclude:
A. Liverdenzymedactivity
B. Protein-bindingd propertiesd ofdtheddrugdmolecule
C. Lipidd solubilityd ofdtheddrug
D. Abilityd todchewdanddswallow
_ 13.d Drugsdadministeredd viadintravenousd (IV)droute:
A. Needdtodbedlipidd solubled indorderdtodbedeasilyd absorbed
B. Begind distributiond intod thed bodydimmediately
C. Aredeasilydabsorbeddifdtheydarednonionized
D. Maydused pinocytosisd todbedabsorbed
_
14.dWhendadmedicationdisdaddeddtodadregimendfordadsynergisticdeffect,dthedcombinedd
effectdofdtheddrugsd is:
A. Thed sumd ofdthedeffectsd ofdeachddrugdindividually
B. Greaterd thand thedsumd ofdthed effectsd ofdeachddrugdindividually
C. Lessdthand thedeffectd ofdeachddrugdindividually
D. Notdpredictable,dasditd variesd withd eachdindividual
, _ 15.d Whichd ofdthed followingd statementsd aboutd bioavailabilityd isd true?
A. Bioavailabilitydissuesdaredespeciallydimportantdforddrugsdwithdnarrowdtherapeuticdr
angesd ordsustainedd released mechanisms.
B. Alld brandsd ofdaddrugdhaved thed samed bioavailability.
C. Drugsdthatdaredadministereddmoredthandoncedaddaydhavedgreaterdbioavailabilitydthandd
rugsd givend onced daily.
D. Combiningd andactived drugd withd andinertd substanced doesdnotd affectd bioavailability.
_ 16.dWhichdofdthedfollowingdstatementsdaboutdthedmajorddistributiondbarriersd(blood-braindordfetal-
placental)disd true?
d
A. Waterdsolubled anddionizedd drugsdcrossdthesedbarriersd rapidly.
B. Thed blood-braind barrierdslowsd thedentryd ofdmanyd drugsd intod anddfromd braind cells.
C. Thed fetal-placentald barrierd protectsdthedfetusd fromd drugsdtakendbydthedmother.
D. Lipidd solubled drugsd dodnotdpassdthesedbarriersd anddaredsafed fordpregnantd women.
_
17.dDrugsdaredmetabolizeddmainlydbydthedliverdviadPhasedIdordPhasedIIdreactions.dThedpu
rposedofbothdofdthesed typesd ofdreactionsd isd to:
A. Inactivated prodrugsd beforedtheydcandbedactivatedd bydtargetd tissues
B. Changed theddrugsd sodtheydcandcrossdplasmad membranes
C. Changed drugdmoleculesd todadformdthatd andexcretoryd organd candexcrete
D. Makedthesed drugsd mored ionizeddanddpolard todfacilitated excretion
_ 18.d Oncedtheydhaved beendmetabolizedd bydthed liver,d thedmetabolitesd maydbe:
A. Moredactived thandthedparentddrug
B. Lessdactived thandthedparentddrug
C. Totallyd “deactivated”d sodthatdtheydaredexcreteddwithoutd anydeffect
D. Alldofdthedabove
_
19.d Alld drugsd continued tod actdind thed bodyduntild theyd ared changedd ordexcreted.d Thed
abilitydofd thedbodydtodexcreted drugsd viad thedrenald systemd wouldd bedincreasedd by:
A. Reducedd circulationd andd perfusiond ofdthed kidney
B. Chronicd renalddisease
C. Competitiond fordadtransportd sited bydanotherd drug
D. Unbindingd adnonvolatiled drugdfromdplasmadproteins
_ 20.d Steadydstatedis:
A. Thed pointd ondtheddrugd concentrationd curved whend absorptiond exceedsdexcretion
B. Whendthed amountd ofddrugd ind thedbodydremainsd constant
C. Whendthed amountd ofddrugdind thedbodydstaysd belowd thedMTC
D. Alldofdthedabove
_ 21.dTwoddifferentd paind medsd aredgivend togetherd ford paind relief.d Thed drug-drugd interactiond is:
A. Synergistic
B. Antagonistic
C. Potentiative
D. Additive
_ 22.d Actionsd takendtodreduced drug-
drugd interactiond problemsd includedalld ofdthed followingdEXCEPT:
A. Reducingd thed dosedofdonedofdthed drugs
B. Schedulingdtheird administrationdatddifferentd times
C. Prescribingd adthirdd drugd todcounteractd thedadversed reactiond ofdthed combination
d d d d d d
Prescribers d
Latest edtion d
Charles R. Drew University of Medicine and Science
d d d d d d d
Chapterd 1:d Thed Roledofd thed Nursed Practitionerdasd Prescriber
Multipled Choice
Identifyd thedchoicedthatdbestdcompletesdthedstatementdordanswersdthedquestion.
_ 1.d Nursedpractitionerd prescriptived authorityd isdregulatedd by:
A. Thed Nationald Councild ofdStatedBoardsdofdNursing
B. Thed U.S.dDrugd Enforcementd Administration
C. Thed StatedBoarddofdNursingd ford eachdstate
D. Thed StatedBoarddofdPharmacy
_ 2.d Physiciand Assistantd (PA)dprescriptived authorityd isdregulatedd by:
A. Thed Nationald Councild ofdStatedBoardsdofdNursing
B. Thed U.S.dDrugd Enforcementd Administration
C. Thed Stated Boardd ofdNursing
D. Thed StatedBoarddofdMedicald Examiners
_ 3.dClinicald judgmentd indprescribingd includes:
A. Factoringd ind thedcostdtodthedpatientd ofdthed medicationd prescribed
B. Alwaysd prescribingd thednewestdmedicationd availabled fordtheddiseasedprocess
C. Handingd outd drugdsamplesd todpoordpatients
D. Prescribingd alldgenericd medicationsd todcutdcosts
_ 4.d Criteriad fordchoosingd andeffectived drugd fordaddisorderdinclude:
A. Askingd thedpatientd whatddrugdtheydthinkd wouldd workdbestdfordthem
B. Consultingdnationallydrecognizedd guidelinesd forddiseasedmanagement
C. Prescribingd medicationsdthatd aredavailabledasdsamplesd befored writingd adprescription
D. Followingd U.S.dDrugd Enforcementd Administrationd (DEA)dguidelinesd ford
prescribing
_ 5.d Nursedpractitionerd practiced maydthrived underdhealth-cared reformdduedto:
A. Theddemonstrateddabilitydofdnursedpractitionersdtodcontroldcostsdanddimprovedpatientdo
utcomes
B. Thedfactdthatdnursed practitionersd willdbedabledtodpracticedindependently
C. Thedfactdthatdnursedpractitionersdwilldhavedfulldreimbursementdunderdhealth-
caredreform
D. Thed abilityd todshiftd accountabilityd fordMedicaidd todthed statedlevel
,Chapterd 1:d Thed Roledofd thed Nursed Practitionerdasd PrescriberdAnswe
rd Section
MULTIPLEd CHOICE
1. ANS:d C PTS:ddd 1
2. ANS:d D PTS:ddd 1
3. ANS:d A PTS:ddd 1
4. ANS:d B PTS:ddd 1
5. ANS:d A PTS:ddd 1
Chapterd 2:d Reviewd ofd Basicd Principlesd ofdPharmacology
Multipled Choice
Identifyd thedchoicedthatdbestdcompletesdthedstatementdordanswersdthedquestion.
_
1.d Adpatient’sd nutritionald intaked anddlabdworkdreflectsd hypoalbuminemia.d Thisd is
dcriticald todprescribingd because:
A. Distributiond ofddrugsd todtargetdtissued maydbedaffected
B. Thed solubilityd ofdtheddrugd willd notdmatchd thed sited ofdabsorption
C. Thered willd bedlessd freed drugd availabledtodgenerated andeffect
D. Drugsd bounddtodalbumind aredreadilyd excretedd bydthed kidney
_ 2.d Drugsd thatd haved adsignificantd first-passd effect:
A. Mustdbedgivend bydthedenterald (oral)d routed only
B. Bypassdthedhepaticdcirculation
C. Aredrapidlyd metabolizedd bydthedliverd andd maydhaved littled ifdanyd desiredd action
D. Aredconvertedd bydthed liverd todmored actived anddfat-solubled forms
_ 3.d Thed routed ofdexcretiond ofdadvolatiled drugdwilld likelyd be:
A. Thedkidneys
B. Thedlungs
C. Thedbiledanddfeces
D. Thedskin
_
4.dMedroxyprogesteroned(DepodProvera)disdprescribeddIMdtodcreatedadstoragedrese
rvoirdofdtheddrug.d Storaged reservoirs:
A. Assuredthatdtheddrugdwilld reachditsdintendedd targetd tissue
B. Aredthedreasondfordgivingd loadingd doses
C. Increased thed lengthdofdtimed addrugdisd availabled anddactive
D. Aredmostdcommond indcollagend tissues
_ 5.d Thed NPdchoosesd todgived cephalexind everyd 8dhoursd baseddondknowledged ofd thed drug’s:
A. Propensityd todgodtodthed targetd receptor
B. Biologicaldhalf-life
C. Pharmacodynamics
D. Safetydanddsidedeffects
_
6.dAzithromycinddosingdrequiresdthedfirstdday’sddosedbedtwicedthosedofdthedotherd4dd
aysdofdthedprescription.dThisd isd consideredd adloadingd dose.dAdloadingd dose:
A. Rapidlyd achievesd drugdlevelsd indthedtherapeuticd range
B. Requiresd fourd todfived half-livesd todattain
, C. Isdinfluenceddbydrenald function
D. Isddirectlyd relatedd todthed drugdcirculatingd todthed targetdtissues
_
7.dThedpointdindtimedondtheddrugdconcentrationdcurvedthatdindicatesdthedfirstdsigndofda
therapeuticdeffectd isd the:
d
A. Minimumdadversedeffectdlevel
B. Peakdofdaction
C. Onsetdofdaction
D. Therapeuticdrange
_ 8.d Phenytoind requiresd adtroughdleveld beddrawn.dPeakdanddtroughd levelsd areddone:
A. Whendtheddrugdhasdadwidedtherapeuticd range
B. Whendthed drugdwilld bedadministereddfordadshortd timed only
C. Whendthered isd adhighd correlationd betweendthed dosedanddsaturationd ofdreceptordsites
D. Toddeterminedifd addrugdisd indthed therapeuticd range
_
9.d Adlaboratorydresultd indicatesd thedpeakdleveld fordaddrugd isdaboved thedmini
mumd toxicdconcentration.d Thisd meansd thatd the:
A. Concentrationd willd producedtherapeuticd effects
B. Concentrationd willd producedandadversedresponse
C. Timed betweenddosesdmustd bedshortened
D. Durationd ofdactiond ofdtheddrugd isdtoodlong
_ 10.d Drugsdthatdaredreceptordagonistsd mayddemonstrated whatd property?
A. Irreversibled bindingd todthed drugdreceptordsite
B. Up-regulationdwithdchronicduse
C. Desensitizationd orddown-regulationd withd continuousduse
D. Inversedrelationshipd betweenddrugdconcentrationd andddrugdaction
_ 11.d Drugsd thatd aredreceptordantagonists,d suchdasdbetadblockers,d maydcause:
A. Down-regulationd ofdtheddrugdreceptor
B. Andexaggeratedd responsedifdabruptlyddiscontinued
C. Partiald blockaded ofdthedeffectsd ofdagonistddrugs
D. Andexaggeratedd responsed todcompetitived drugdagonists
_ 12.d Factorsdthatdaffectd gastricd drugdabsorptiondinclude:
A. Liverdenzymedactivity
B. Protein-bindingd propertiesd ofdtheddrugdmolecule
C. Lipidd solubilityd ofdtheddrug
D. Abilityd todchewdanddswallow
_ 13.d Drugsdadministeredd viadintravenousd (IV)droute:
A. Needdtodbedlipidd solubled indorderdtodbedeasilyd absorbed
B. Begind distributiond intod thed bodydimmediately
C. Aredeasilydabsorbeddifdtheydarednonionized
D. Maydused pinocytosisd todbedabsorbed
_
14.dWhendadmedicationdisdaddeddtodadregimendfordadsynergisticdeffect,dthedcombinedd
effectdofdtheddrugsd is:
A. Thed sumd ofdthedeffectsd ofdeachddrugdindividually
B. Greaterd thand thedsumd ofdthed effectsd ofdeachddrugdindividually
C. Lessdthand thedeffectd ofdeachddrugdindividually
D. Notdpredictable,dasditd variesd withd eachdindividual
, _ 15.d Whichd ofdthed followingd statementsd aboutd bioavailabilityd isd true?
A. Bioavailabilitydissuesdaredespeciallydimportantdforddrugsdwithdnarrowdtherapeuticdr
angesd ordsustainedd released mechanisms.
B. Alld brandsd ofdaddrugdhaved thed samed bioavailability.
C. Drugsdthatdaredadministereddmoredthandoncedaddaydhavedgreaterdbioavailabilitydthandd
rugsd givend onced daily.
D. Combiningd andactived drugd withd andinertd substanced doesdnotd affectd bioavailability.
_ 16.dWhichdofdthedfollowingdstatementsdaboutdthedmajorddistributiondbarriersd(blood-braindordfetal-
placental)disd true?
d
A. Waterdsolubled anddionizedd drugsdcrossdthesedbarriersd rapidly.
B. Thed blood-braind barrierdslowsd thedentryd ofdmanyd drugsd intod anddfromd braind cells.
C. Thed fetal-placentald barrierd protectsdthedfetusd fromd drugsdtakendbydthedmother.
D. Lipidd solubled drugsd dodnotdpassdthesedbarriersd anddaredsafed fordpregnantd women.
_
17.dDrugsdaredmetabolizeddmainlydbydthedliverdviadPhasedIdordPhasedIIdreactions.dThedpu
rposedofbothdofdthesed typesd ofdreactionsd isd to:
A. Inactivated prodrugsd beforedtheydcandbedactivatedd bydtargetd tissues
B. Changed theddrugsd sodtheydcandcrossdplasmad membranes
C. Changed drugdmoleculesd todadformdthatd andexcretoryd organd candexcrete
D. Makedthesed drugsd mored ionizeddanddpolard todfacilitated excretion
_ 18.d Oncedtheydhaved beendmetabolizedd bydthed liver,d thedmetabolitesd maydbe:
A. Moredactived thandthedparentddrug
B. Lessdactived thandthedparentddrug
C. Totallyd “deactivated”d sodthatdtheydaredexcreteddwithoutd anydeffect
D. Alldofdthedabove
_
19.d Alld drugsd continued tod actdind thed bodyduntild theyd ared changedd ordexcreted.d Thed
abilitydofd thedbodydtodexcreted drugsd viad thedrenald systemd wouldd bedincreasedd by:
A. Reducedd circulationd andd perfusiond ofdthed kidney
B. Chronicd renalddisease
C. Competitiond fordadtransportd sited bydanotherd drug
D. Unbindingd adnonvolatiled drugdfromdplasmadproteins
_ 20.d Steadydstatedis:
A. Thed pointd ondtheddrugd concentrationd curved whend absorptiond exceedsdexcretion
B. Whendthed amountd ofddrugd ind thedbodydremainsd constant
C. Whendthed amountd ofddrugdind thedbodydstaysd belowd thedMTC
D. Alldofdthedabove
_ 21.dTwoddifferentd paind medsd aredgivend togetherd ford paind relief.d Thed drug-drugd interactiond is:
A. Synergistic
B. Antagonistic
C. Potentiative
D. Additive
_ 22.d Actionsd takendtodreduced drug-
drugd interactiond problemsd includedalld ofdthed followingdEXCEPT:
A. Reducingd thed dosedofdonedofdthed drugs
B. Schedulingdtheird administrationdatddifferentd times
C. Prescribingd adthirdd drugd todcounteractd thedadversed reactiond ofdthed combination
