COMPLETE SOLUTIONS VERIFIED LATEST UPDATE
Which drug promotes hemostasis by inhibition of fibrinolysis?
a) Celecoxib
b) Desmopressin
c) Diphenhydramine
d) Aminocaproic acid
d) Aminocaproic acid
Rationale: Aminocaproic acid inhibits fibrinolysis by blocking the production of plasmin.
Consequently, it promotes hemostasis in patients with hemophilia A. Celecoxib is a
cyclooxygenase-2 inhibitor that does not suppress platelet aggregation; however, its
safety for pain management in hemophilia has not been proven. Desmopressin may be
useful to stop bleeding by promoting the release of stored factor VIII. Diphenhydramine
is an antihistamine that may be administered to treat symptoms of mild reaction to
administration of factor VIII. pg 632
In which patients is hemophilia almost exclusively seen?
a) Males
b) Females
, c) Hispanics
d) Caucasians
a) Males
Rationale: Hemophilia is a genetically based bleeding disorder seen almost exclusively
in males. Because males have only one X chromosome, a male with a defective gene
has hemophilia. In contrast, a female with a defective gene on just one X chromosome
is an asymptomatic carrier. It is not more predominant in any one race. pg 627
Which route of administration is appropriate to administer argatroban?
a) Intradermal
b) Intravenous
c) Intramuscular
d) Subcutaneous
b) Intravenous
Rationale: Argatroban is given only by the intravenous route as a continuous infusion.
Argatroban is not approved for intradermal, intramuscular, or subcutaneous
administration. pg 606
Which frequency of bleeding is seen in a patient with moderate hemophilia?
a) Once monthly
b) During mild injuries