Test Bank For Lippincott Illustrated Reviews Pharmacology 7th Edition by Karen Whalen 9781496384133 Chapter 1-48 All Chapters with Answers and Rationals 2

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stageqAlzheimer'sqdiseaseqandqdysphagiaqisqtakingqmultipleqmedications.qPhysicalqexa
minationqrevealsqxerostomiaqandqaqlimitedqgagqreflex.qWhichqofqtheqfollowingqroutesqofq
medicationqadministrationqwouldqprovideqtheqlowestqserumqdrugqconcentration?q(A)qEn
teralq(B)qIntramuscularq(C)qIntrathecalq(D)qIntravenousq(E)qTransdermalq-
qANSWERqqqANSWERSq1qTheqanswerqisqA:qEnteral.qThisqpatientqhasqdysphagiaqandqAl

zheimer'sqdisease.qTheseqconditionsqwouldqmakeqdrugqadministrationqbyqmouthqdifficul
tqandqlimitqdirectqabsorptionqviaqtheqstomach.qThisqrouteqofqdrugqadministrationqwouldqgi
veqtheqlowestqserumqdrugqconcentrationsqforqtheqreasonsqdescribedqpreviously.q(B)qIntr
amuscularqadministration,qalthoughqpainfulqforqtheqpatient,qwouldqgiveqacceptableqseru
mqdrugqconcentrations.q(C)qIntrathecalqadministrationqwouldqgiveqacceptableqtherapeut
icqdrugqconcentrationsqbutqwouldqbeqlimitedqtoqCNSqdiseaseqstates.q(D)qIntravenousqad
ministrationqwouldqprovideqmedicationsqviaqveinqandqtherapeuticqdrugqconcentrations.qI
tqcouldqbequsedqforqvariousqmedications.q(E)qTransdermalqadministrationqappliesqmedic
ationsqtoqtheqskinqandqcouldqachieveqtherapeuticqdrugqconcentrations.

2qAq28-year-oldqmanqwithqseborrheicqdermatitisqisqpre-
qscribedqaqtopicalqcorticosteroidqcrèmeqbyqhisqderma-

qtologistqinqhopesqofqalleviatingqtheqchronicqrashqandqerythemaqonqtheqcheeks.qWhichqof

qtheqfollowingqstepsqisqmostqcriticalqtoqachieveqaqtherapeuticqdrugqconcen-

qtrationqinqplasma?q(A)qAbsorptionq(B)qDistributionq(C)qEliminationq(D)qGlycosylationq(E)

qMetabolismq-qANSWERqqqTheqanswerqisqA:qAbsorption.qDrugqabsorptionqfrom

theqsiteqofqadministration,qinqthisqcaseqviaqtheqtopical
route,qallowsqtheqmedicationqtoqenterqintoqtheqskin
andqthenqintoqtheqplasma.qFollowingqthisqstep,qthe
medicationqcanqdistributeqintoqtissuesqandqalsoqbe
metabolizedqinqtissues.

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thmaqattacksqrequiringqintubationqforqairwayqmaintenance.qHeqisqnoncompli-
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youngqmanqinqacuteqdistress.qHisqroomqairqoxygenqsaturationqisq87%.qInqadditionqtoqad
ministrationqofqoxygen,qimmediateqdrugqadministrationqofqalbuterolqshouldqbeqadminist
eredqbyqwhichqofqtheqfollowingqroutes?q(A)qInhalationq(B)qIntranasalqpuffqmeteredqdoseq(
C)qSubcutaneousq(D)qSublingualq(E)qTopicalq-
qANSWERqqqTheqanswerqisqA:qInhalation.qInhalationqprovidesqrapidqdeliveryqofqaqdrugqac

rossqaqlargeqsurfaceqareaqofqtheqrespiratoryqtractqandqisqtheqrouteqofqadministrationqofqch
oiceqinqaqpatientqwithqanqairwayqdiseaseqsuchqasqasthma.qInhaledqalbuterolqisqcommonl
yqadministered

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timeq100qmgqdoseqofqoralqfluconazole.qSheqhasqnoqotherqpertinentqmedicalqproblemsqan
dqtakesqnoqprescriptionqmedications.qAdministrationqofqtheqmedicationqresultsqinqaqpeak

,qplasmaqconcentrationqofq20qmg/mL.qWhatqisqtheqapparentqvolumeqofqdrugqdistribution?q
(A)q0.5qLq(B)q1qLq(C)q3qLq(D)q5qLq(E)q50qLq-
qANSWERqqqTheqanswerqisqA:qInhalation.qInhalationqprovidesqrapidqdeliveryqofqaqdrugqac

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oiceqinqaqpatientqwithqanqairwayqdiseaseqsuchqasqasthma.qInhaledqalbuterolqisqcommonl
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qpleqintravenousqmedications.qWhichqofqtheqfollowingqmedicationsqisqlikelyqtoqbeqtherap

euticqforqthisqpatient?q(A)qEpinephrineq(B)qErythromycinq(C)qNifedipineq(D)qRifampinq(E)
qVerapamilq-

qANSWERqqqTheqanswerqisqA:qEpinephrine.qThisqpatientqhasqendstageqliverqdisease.qTh

isqabilityqtoqmetabolizeqmedicationsqthroughqtheqcytochromeqsystemqofqtheqliverqisqimpai
red.qDrugsqthatqareqmetabolizedqinqthisqfashionqwillqnotqbeqproperlyqbrokenqdownqandqwi
llqaccumulateqtoqtoxicqlevels.qEpinephrineqisqnotqmetabolizedqbyqtheqcytochromeqsyste
mqandqcanqbequsedqwithqcautionqinqthisqpatient.q(

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qlevel?q(A)q10qhq(B)q20qhq(C)q30qhq(D)q40qhq(E)q50qhq-

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achq90%qofqitsqfinalqsteadyqstate,quseqtheqformula:q(3.3)q3q(t1/2).qInqthisqcase,qtheqhalf-
lifeqisq12qh.qThus,q(3.3)q3q(12)qisqapproximatelyq40qh.qOfqnote,qbecauseqofqpoorqpenetrati
onqintoqprostateqtissues,qdespiteqachievingq90%qsteadyqstateqlevelsqinq40qh,qpatientsqwit
hqthisqconditionqoftenqneedqtoqtakeqantibioticsqforqapproximatelyq3qtoq4qweeksqforqcure

Aqhospitalizedqpatientqwithqsystemicqcandidiasisqisqreceivingqintravenousqantifungalqme
dications.qHeqalsoqhasqhepaticqandqrenalqinsufficiency.qWhichqofqtheqfollowingqdrugqad
ministrationqschemesqwouldqallowqforqtheqmostqsteadyqstateqamountqofqdrugqinqtheqbody
qoverqaq2-

weekqhospitalizationqperiodqwhereqmedicationqadministrationqwillqbeqnecessary?q(A)qC
ontinuousqIVqinfusionq(B)qOnceqweeklyqIVqinjectionq(C)qSingleqdailyqIVqinjectionq(D)qTwi
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ffectqsoqtheqpatient'sqliverqinsufficiencyqwouldqnotqlikelyqbeqproblematicqwithqthisqrouteqof
qadministration.q(A)qEnteralqrouteqadministrationqwillqbequnlikelyqtoqachieveqanqadequat

eqtherapeuticqresponseqinqaqpatientqwithqhemorrhoids.q(B)qIntramuscularqrouteqadminist
rationqisqanqineffectiveqtherapyqforqrectalqdiseases.q(C)qIntravenousqadministrationqisqan
qineffectiveqtherapyqforqrectalqdiseasesqsuchqasqhemorrhoid




11qTheqP-
glycoproteinqisqaqmultidrugqtransmembraneqreceivingqintravenousqantifungalqmedicatio
ns.qHeqalsoq-qANSWERqqq

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ncy.qWhichqofqtheqfol-q-qANSWERqqq

cellqmembranes.qFunctionsqofqthisqproteinqincludeqlowingqdrugqadministrationqschemes
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(A)qPumpingqdrugsqintoqthequrineqforqexcretionqtheqmostqsteadyqstateqamountqofqdrugqinq
theqbodyqoverqaq2-
weekqhospitalizationqperiodqwhereqmedicationqadministrationqwillqbeqnecessary?q(A)qC
ontinuousqIVqinfusionq(B)qOnceqweeklyqIVqinjectionq-qANSWERqqq

(B)qTransportqofqdrugsqintoqliverqhepatocytesq(C)qTransportqofqdrugsqintoqfetalqcirculatio
nqforqfetalq-qANSWERqqq

treatmentq(D)qTransportqofqdrugsqfromqtheqintestinalqlumenqtoq-qANSWERqqq

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qANSWERqqq




brainqcellsq(E)qTwiceqweeklyqIVqinjectionq-qANSWERqqq

12qAqresearcherqisqstudyingqtheqbioavailabilityqofqcom-q8qAq27-year-
oldqmanqwithqHIVqdiseaseqandqhepaticq-qANSWERqqq

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yqcareqphysicianq-qANSWERqqq

syndrome.qMedicationqAqisqadministeredqinqaq100qmgqcomplainingqofqrectalqpainqandqbl
eedingqwithqbowelq-qANSWERqqq

dailyqdoseqorallyqandq60qmgqofqtheqdrugqisqabsorbedqmovements.qPhysicalqexamination
qrevealsqseveralqin-q-qANSWERqqq




fromqtheqgastrointestinalqtractqunchanged.qThus,qtheqternalqandqexternalqhemorrhoids.q
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bioavailabilityqofqMedicationqAqisqlikeqtoqavoidqsurgicalqtherapyqforqthisqcondition.q-
qANSWERqqq




(A)q50%qWhichqofqtheqfollowingqroutesqofqdrugqadministrationq-qANSWERqqq

(B)q60%qwouldqbeqpreferredqinqthisqpatient?q(A)qEnteralq(B)qIntramuscularq(C)qIntraveno
usq-qANSWERqqq

(C)q70%q(D)q80%q(E)q90%q-qANSWERqqq

(D)qRectalq-qANSWERqqq