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Immune System (Parts & Function): Integumentary System - ✔✔Provides
physical barriers and non-specific innate immunity:
1. Cutaneous membranes: cover and protect exterior surfaces of body
2. Mucous membranes: line and protect body cavities and organs
3. Serous membranes: surround and protect organs
4. Synovial membranes: line and protect joints
5. Adipose tissue: communicates metabolic state of body to immune
system via hormones called adipokines, which in turn control immune cell
activity
Immune System (Parts & Function): Digestive System - ✔✔Provides
physical barriers, innate and adaptive immunity:
1. HCl and pepsin: neutralizes pathogens before entering intestine
2. GALT: houses 70-80% of immune system cells
3. Epithelial cells: secrete protective mucous as barrier against colonization
and invasion by pathogens (1 layer thick in small intestine; 2 layers thick in
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,large intestine), rich in antimicrobial proteins like lysozyme (enzyme that
catalyzes destruction of cell walls of certain bacteria), facilitate nutrient
digestion and assimilations, provide immunological surveillance signals at
gut-mucosa-lumen interaface
4. Gut Flora in Large Intestine: stimulates immunity, feeds epithelial cells
(produce SFAs for fuel), crowds out pathogenic bacteria
Immune System (Parts & Function): Lymphatic System- Primary Organs &
Tissues - ✔✔-Bone Marrow
-Thymus
Immune System (Parts & Function): Bone Marrow - ✔✔-Spongy tissue
inside bones where all new blood cells and immune cells are created
-Housed mainly in central skeletal system--pelvis, sternum, cranium, ribs,
vertebrae, scapulae, femur
Immune System (Parts & Function): Thymus - ✔✔-Adaptive immune
response "school" where T cells are taught how to respond to specific
pathogens and how to differentiate between self-cells and invaders
-Immature T cells migrate from b_______ m____________ to
t_______________ to continue development
-Once mature, T cells migrate to other lymphatic tissue and organs where
they become active when needed
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,Immune System (Parts & Function): Lymphatic System- Secondary Organs
& Tissues - ✔✔-Lymph nodes
-Lymphatic vessels
-Lymphatic fluid
-MALT (Mucosal-Associated Lymphoid Tissue)
-Spleen
Main transportation systems and "meet-up spots" for pathogens, antigens,
phagocytes, B cells, and T cells
Immune System (Parts & Function): Lymph Nodes - ✔✔-"Dating bars"
where B and T cells meet antigens and antigen presenting cells
-Antigens and antigen presenting cells enter through incoming arteriole or
(afferent) lymphatic vessel (a way to catch invaders)
-B cells, T cells and antigen presenting cells circulate through lymphatic
system until they make a "match"
-Provide "factory space" for B and T cells to proliferate in response to a
specific pathogen or antigen
-Scattered throughout body, both superficial and deep
Immune System (Parts & Function): Lymphatic Vessel - ✔✔-Entry point for
antigens and antigen presenting cells
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, -Closed at one end and start as small lymphatic capillaries in tissues
-Carry lymph that forms in tissues to larger l_______________
v________________
-Along with blood stream, this acts as highways to transport cells and
substances to the scene of the "crime"
Immune System (Parts & Function): MALT - ✔✔Mucosal Associated
Lymphoid Tissue
-Specialized lymphatic tissue situated along all mucosal surfaces of the
body
-Found in skin, eyes, nose, mouth, tonsils, GI tract, respiratory tract, urinary
tract, reproductive tract,
-Provide sites for macrophages, B cells and T cells to meet up with
pathogens and antigens (microbes, viruses, parasites, allergens)
-Stand watch over body's barriers by communicating directly with mucosal
surfaces
-Outgoing lymphatics connect these vessels with lymphatic system
Immune System (Parts & Function): MALT Subcategories - ✔✔-Stand
watch over body's barriers by communicating directly with mucosal
surfaces
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