NURG 533 Patho Module 12: Integument
1. They secrete sebum, composed primarily of lipids, that oils the skin and hair and prevents drying. Growth is
stimulated by androgens, and their enlarge- ment is one of the early signs of puberty.: sebaceous glands
2. Where are sebaceous glands located?: the dermis
3. What happens to sebaceous glands as we age?: They atrophy, skin is more dry
4. These are sites for acne lesions: sebaceous follicles
5. An increase in the size and productivity of the sebaceous glands results in an excessive production of sebum
related to androgenic hormones; what can this cause?: acne vulgaris
6. This is a chronic, relapsing, proliferative, inflammatory skin disorder. It is a T-cell autoimmune-mediated skin
disease.: Psoriasis
7. What are some clinical manifestations of psoriasis?: scaly, thick, silvery, and elevated lesions, usually on scalp,
face, trunk, elbows, or knees. Dermal and epidermal thickening is evident.
8. Which type of psoriasis is characterized by lesions on the elbows and knees that are well demarcated, thick,
silvery, scaly, and erythematous?: Plaque psoriasis
9. Which medications may exacerbate existing psoriasis?: Beta-blockers and lithium.
10.This is exfoliative dermatitis characterized by widespread red, scaling lesions: Erythrodermic psoriasis
11.also known as hives: urticaria
12.due to type I hypersensitivity reactions to allergens.
Histamine release causes endothelial cells of the skin to contract.: Hives
13.What are some clinical manifestations of hives (urticaria)?: Pruritic circum- scribed area of raised erythema
with central pallor; wheals, welts
14.What are some treatment options for hives?: Antihistamines, leukotriene-re- ceptor agonists, ±a-drenergic
agonists, steroids
15.Which skin lesion is mediated by IgE-stimulated release of histamine, bradykinin, kallikrein, or
acetylcholine from mast cells?: Urticarial lesions.
16.Which malignancy is characterized by slow-growing lesions that usually have depressed centers and rolled
borders and are frequently located on the face and neck?: Basal cell carcinoma
17.The alteration of which gene is associated with basal cell carcinoma?: aris- es from mutation in the TP53
1/
9
, NURG 533 Patho Module 12: Integument
tumor-suppressor gene, leading to loss of keratinocyte repair functions and apoptosis resistance of DNA-damaged cells.
Other oncogenic pathways include inhibition of the PTCH gene with over exposure
2/
9
1. They secrete sebum, composed primarily of lipids, that oils the skin and hair and prevents drying. Growth is
stimulated by androgens, and their enlarge- ment is one of the early signs of puberty.: sebaceous glands
2. Where are sebaceous glands located?: the dermis
3. What happens to sebaceous glands as we age?: They atrophy, skin is more dry
4. These are sites for acne lesions: sebaceous follicles
5. An increase in the size and productivity of the sebaceous glands results in an excessive production of sebum
related to androgenic hormones; what can this cause?: acne vulgaris
6. This is a chronic, relapsing, proliferative, inflammatory skin disorder. It is a T-cell autoimmune-mediated skin
disease.: Psoriasis
7. What are some clinical manifestations of psoriasis?: scaly, thick, silvery, and elevated lesions, usually on scalp,
face, trunk, elbows, or knees. Dermal and epidermal thickening is evident.
8. Which type of psoriasis is characterized by lesions on the elbows and knees that are well demarcated, thick,
silvery, scaly, and erythematous?: Plaque psoriasis
9. Which medications may exacerbate existing psoriasis?: Beta-blockers and lithium.
10.This is exfoliative dermatitis characterized by widespread red, scaling lesions: Erythrodermic psoriasis
11.also known as hives: urticaria
12.due to type I hypersensitivity reactions to allergens.
Histamine release causes endothelial cells of the skin to contract.: Hives
13.What are some clinical manifestations of hives (urticaria)?: Pruritic circum- scribed area of raised erythema
with central pallor; wheals, welts
14.What are some treatment options for hives?: Antihistamines, leukotriene-re- ceptor agonists, ±a-drenergic
agonists, steroids
15.Which skin lesion is mediated by IgE-stimulated release of histamine, bradykinin, kallikrein, or
acetylcholine from mast cells?: Urticarial lesions.
16.Which malignancy is characterized by slow-growing lesions that usually have depressed centers and rolled
borders and are frequently located on the face and neck?: Basal cell carcinoma
17.The alteration of which gene is associated with basal cell carcinoma?: aris- es from mutation in the TP53
1/
9
, NURG 533 Patho Module 12: Integument
tumor-suppressor gene, leading to loss of keratinocyte repair functions and apoptosis resistance of DNA-damaged cells.
Other oncogenic pathways include inhibition of the PTCH gene with over exposure
2/
9
