Summary PHARM: Pharmacokinetics Summaries

PHARM: Pharmacokinetics Summaries


1. Pharmacokinetics: The study of drug movement through the body
2. The four pharmacokinetic processes: ADME
- Absorption
- Distribution
- Metabolism
- Excretion
3. Extent of drug movement depends on what?: the ability of drugs to pass to and from the major spaces of the body:
- intracellular
- intravascular
- interstitial
4. In many cases, drugs can pass freely between what?: between wide junctions, or gaps, in a capillary wall
5. At other times drugs must pass across membranes via...: - Channels or pores
- Transport systems
- Direct membrane penetration
6. For Direct membrane penetration, drug must be...: lipid soluble, nonpolar, or nonionized
7. Absorption: Movement of a drug from site of administration into the blood
8. Rate of absorption: How quickly the drug moves into the bloodstream
9. Amount of absorption: How much of the drug moves into the bloodstream
10.What does the rate and amount of absorption depend on?: - Drug
- Route of administration
11.Rate of absorption is FASTEST at which route?: IV
12.Rate of absorption is SLOWEST at which route?: Orally
13.Factors affecting absorption: - Rate of dissolution
- Surface area
- Blood flow
- Lipid solubility
- pH partitioning
14.Routs of Administration Types: 1. Parenteral
2. Enteral
15.Parenteral: Outside of GI tract
- Intravenous (IV)
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, PHARM: Pharmacokinetics Summaries
- Intramuscular (IM)
- Subcutaneous (subQ)
16.Enteral: Using the GI tract
- Mouth
- Feeding tubes




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