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NR 507 Midterm Exam Questions and Answers
100% Pass
Allergic contact dermatitis is an example of - ANSWER ✔✔-Type 4 hypersensitivity reaction
Which of the following are considered the "first responders" of the innate immune system? (Appear first
in any immune response) - ANSWER ✔✔-Neutrophils
Hives (Urticaria) are an example of a - ANSWER ✔✔-Type 1 hypersensitivity reaction
Type 2 (cytotoxic) hypersensitivity reactions are mediated by: - ANSWER ✔✔-IgG or IgM
Anaphylaxis is a - ANSWER ✔✔-Type 1 hypersensitivity reaction
Type 1 hypersensitivity reactions are mediated by - ANSWER ✔✔-IgE and mast cells
Example of Type 1 hypersensitivity reaction - ANSWER ✔✔-Hay fever
Most dangerous form of Type 1 hypersensitivity reaction - ANSWER ✔✔-Anaphylactic reaction systemic
response causing hypotension and severe bronchoconstriction
Local symptoms of Type 1 hypersensitivity - ANSWER ✔✔-Itching, rash
Systemic symptoms of Type 1 hypersensitivity reaction - ANSWER ✔✔-Wheezing
Main treatment of anaphylaxis - ANSWER ✔✔-Epinephrine
Example of Type 2 hypersensitivity reaction - ANSWER ✔✔-ABO incompatibility
Graves Disease (hyperthyroidism)
Primary effector cells involved in Type 2 hypersensitivity reactions - ANSWER ✔✔-Macrophages
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Type 2 hypersensitivity reactions - ANSWER ✔✔--Tissue specific
-Can cause tissue damage or alter function
Type 4 hypersensitivity reactions are mediated by - ANSWER ✔✔-Caused by cytotoxic T cells attacking
tissue directly (no antibody)
Which of the following is the underlying pathology for hay fever? - ANSWER ✔✔-Mast cell
degranulation
Damage occurs with ABO incompatibility because - ANSWER ✔✔-Complement damages RBC
membrane causing RBC lysis
Which of the following assessment findings would be expected in a patient who presents with urticaria? -
ANSWER ✔✔-Eosinophilia
Example of Type 4 hypersensitivity reaction - ANSWER ✔✔-Contact dermatitis (poison ivy, metal
allergy)
Type 3 hypersensitivity reactions - ANSWER ✔✔-- Are NOT organ specific
- antigen-antibody complex deposited in tissues
Type 3 hypersensitivity reaction examples - ANSWER ✔✔-Rheumatoid Arthritis
Systemic Lupus Erythematous (SLE)
Scope of Damage of SLE - ANSWER ✔✔-- Facial rash confined to the cheeks (malar rash)
- Discoid rash (raised patches, scaling)
- photosensitivity (development of skin rash as a results of sunlight exposure)
- oral or nasopharyngeal ulcers
Created by Grace Amelia © 2025, All Rights Reserved.
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- hematologic disorders (hemolytic anemia, leukopenia, lymphopenia, or thrombocytopenia)
- immunologic disorders (antibodies against double-stranded DNA or Smith antigen, false positive
serologic tests for syphilis, or antiphospholipid antibodies)
- Non-erosive arthritis of at least 2 peripheral joints
- Serositis (pleurisy, pericarditis)
- renal disorder (persistent proteinuria of > 0.5 g/day or > 3 g/day on dipstick of cellular casts)
- neurological disorders (seizures, psychosis)
- presence of antinuclear antibody (ANA)
Autoimmune diseases can be - ANSWER ✔✔-Familial although not all develop the same disease, but
several members may have different disorders characterized by a variety of hypersensitivity reactions
Associations with particular autoimmune diseases have been identified for a variety of - ANSWER ✔✔-
Major histocompatibility complex (MHC) alleles or non-MHC genes
Alloimmunity - ANSWER ✔✔-General term used to describe when an individuals immune system
reactions against antigens on the tissues of other members of the same species
Examples of alloimmunity - ANSWER ✔✔-- Neonatal disease where the maternal immune system
becomes sensitized against antigens expressed by the fetus
- transplant rejection
- transfusion reaction
A rash in Type 1 hypersensitivity reaction - ANSWER ✔✔-Immediate reaction, termed atopic dermatitis,
usually characterized by widely distributed lesions
Created by Grace Amelia © 2025, All Rights Reserved.
NR 507 Midterm Exam Questions and Answers
100% Pass
Allergic contact dermatitis is an example of - ANSWER ✔✔-Type 4 hypersensitivity reaction
Which of the following are considered the "first responders" of the innate immune system? (Appear first
in any immune response) - ANSWER ✔✔-Neutrophils
Hives (Urticaria) are an example of a - ANSWER ✔✔-Type 1 hypersensitivity reaction
Type 2 (cytotoxic) hypersensitivity reactions are mediated by: - ANSWER ✔✔-IgG or IgM
Anaphylaxis is a - ANSWER ✔✔-Type 1 hypersensitivity reaction
Type 1 hypersensitivity reactions are mediated by - ANSWER ✔✔-IgE and mast cells
Example of Type 1 hypersensitivity reaction - ANSWER ✔✔-Hay fever
Most dangerous form of Type 1 hypersensitivity reaction - ANSWER ✔✔-Anaphylactic reaction systemic
response causing hypotension and severe bronchoconstriction
Local symptoms of Type 1 hypersensitivity - ANSWER ✔✔-Itching, rash
Systemic symptoms of Type 1 hypersensitivity reaction - ANSWER ✔✔-Wheezing
Main treatment of anaphylaxis - ANSWER ✔✔-Epinephrine
Example of Type 2 hypersensitivity reaction - ANSWER ✔✔-ABO incompatibility
Graves Disease (hyperthyroidism)
Primary effector cells involved in Type 2 hypersensitivity reactions - ANSWER ✔✔-Macrophages
Created by Grace Amelia © 2025, All Rights Reserved.
,2|Page
Type 2 hypersensitivity reactions - ANSWER ✔✔--Tissue specific
-Can cause tissue damage or alter function
Type 4 hypersensitivity reactions are mediated by - ANSWER ✔✔-Caused by cytotoxic T cells attacking
tissue directly (no antibody)
Which of the following is the underlying pathology for hay fever? - ANSWER ✔✔-Mast cell
degranulation
Damage occurs with ABO incompatibility because - ANSWER ✔✔-Complement damages RBC
membrane causing RBC lysis
Which of the following assessment findings would be expected in a patient who presents with urticaria? -
ANSWER ✔✔-Eosinophilia
Example of Type 4 hypersensitivity reaction - ANSWER ✔✔-Contact dermatitis (poison ivy, metal
allergy)
Type 3 hypersensitivity reactions - ANSWER ✔✔-- Are NOT organ specific
- antigen-antibody complex deposited in tissues
Type 3 hypersensitivity reaction examples - ANSWER ✔✔-Rheumatoid Arthritis
Systemic Lupus Erythematous (SLE)
Scope of Damage of SLE - ANSWER ✔✔-- Facial rash confined to the cheeks (malar rash)
- Discoid rash (raised patches, scaling)
- photosensitivity (development of skin rash as a results of sunlight exposure)
- oral or nasopharyngeal ulcers
Created by Grace Amelia © 2025, All Rights Reserved.
, 3|Page
- hematologic disorders (hemolytic anemia, leukopenia, lymphopenia, or thrombocytopenia)
- immunologic disorders (antibodies against double-stranded DNA or Smith antigen, false positive
serologic tests for syphilis, or antiphospholipid antibodies)
- Non-erosive arthritis of at least 2 peripheral joints
- Serositis (pleurisy, pericarditis)
- renal disorder (persistent proteinuria of > 0.5 g/day or > 3 g/day on dipstick of cellular casts)
- neurological disorders (seizures, psychosis)
- presence of antinuclear antibody (ANA)
Autoimmune diseases can be - ANSWER ✔✔-Familial although not all develop the same disease, but
several members may have different disorders characterized by a variety of hypersensitivity reactions
Associations with particular autoimmune diseases have been identified for a variety of - ANSWER ✔✔-
Major histocompatibility complex (MHC) alleles or non-MHC genes
Alloimmunity - ANSWER ✔✔-General term used to describe when an individuals immune system
reactions against antigens on the tissues of other members of the same species
Examples of alloimmunity - ANSWER ✔✔-- Neonatal disease where the maternal immune system
becomes sensitized against antigens expressed by the fetus
- transplant rejection
- transfusion reaction
A rash in Type 1 hypersensitivity reaction - ANSWER ✔✔-Immediate reaction, termed atopic dermatitis,
usually characterized by widely distributed lesions
Created by Grace Amelia © 2025, All Rights Reserved.
