,ALGrawany
,MARINO’S
The
ICU Book
FIFTH EDITION
Paul L. Marino, MD, PhD, FCCM
Clinical Associate Professor
Weill Cornell Medical College
New York, New York
Illustrations by Patricia Gast
, Acquisitions Editor: Keith Donnellan
Senior Development Editor: Ashley Fischer
Marketing Manager: Kirsten Watrud
Production Project Manager: Bridgett Dougherty
Manager, Graphic Arts & Design: Stephen Druding, Diane Drier
Manufacturing Coordinator: Lisa Bowling
Prepress Vendor: Aptara, Inc.
5th Edition
Copyright © 2025 Wolters Kluwer.
4th Edition © 2014 by Wolters Kluwer Health/Lippincott Williams & Wilkins. 3rd Edition © 2007 by Lippincott Williams &
Wilkins - a Wolters Kluwer Business. 2nd Edition © 1998 by LIPPINCOTT WILLIAMS & WILKINS. All rights reserved. This
book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as
photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written
permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in
this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-
mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street,
Philadelphia, PA 19103, via email at , or via our website at shop.lww.com (products and services).
987654321
Printed in Mexico
ISBN: 978-1-975176-71-6
LCCN: 2024946263
Library of Congress Cataloging-in-Publication Data available upon request
This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any warranties as
to accuracy, comprehensiveness, or currency of the content of this work.
This work is no substitute for individual patient assessment based upon healthcare professionals’ examination of each patient and
consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data
and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a
reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all
medical judgments and for any resulting diagnosis and treatments.
Given continuous, rapid advances in medical science and health information, independent professional verification of medical
diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare
professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult
the product information sheet (the manufacturer’s package insert) accompanying each drug to verify, among other things,
conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the
medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted
under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a
matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.
shop.lww.com
ALGrawany
,MARINO’S
The
ICU Book
FIFTH EDITION
Paul L. Marino, MD, PhD, FCCM
Clinical Associate Professor
Weill Cornell Medical College
New York, New York
Illustrations by Patricia Gast
, Acquisitions Editor: Keith Donnellan
Senior Development Editor: Ashley Fischer
Marketing Manager: Kirsten Watrud
Production Project Manager: Bridgett Dougherty
Manager, Graphic Arts & Design: Stephen Druding, Diane Drier
Manufacturing Coordinator: Lisa Bowling
Prepress Vendor: Aptara, Inc.
5th Edition
Copyright © 2025 Wolters Kluwer.
4th Edition © 2014 by Wolters Kluwer Health/Lippincott Williams & Wilkins. 3rd Edition © 2007 by Lippincott Williams &
Wilkins - a Wolters Kluwer Business. 2nd Edition © 1998 by LIPPINCOTT WILLIAMS & WILKINS. All rights reserved. This
book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as
photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written
permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in
this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-
mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street,
Philadelphia, PA 19103, via email at , or via our website at shop.lww.com (products and services).
987654321
Printed in Mexico
ISBN: 978-1-975176-71-6
LCCN: 2024946263
Library of Congress Cataloging-in-Publication Data available upon request
This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any warranties as
to accuracy, comprehensiveness, or currency of the content of this work.
This work is no substitute for individual patient assessment based upon healthcare professionals’ examination of each patient and
consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data
and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a
reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all
medical judgments and for any resulting diagnosis and treatments.
Given continuous, rapid advances in medical science and health information, independent professional verification of medical
diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare
professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult
the product information sheet (the manufacturer’s package insert) accompanying each drug to verify, among other things,
conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the
medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted
under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a
matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.
shop.lww.com
ALGrawany
