,Wecker: Brody’s Human Pharmacology, 5th Edition
b b b b b
Chapterb01:bPharmacodynamics:bReceptorsbandbConcentration-ResponsebRelationships
TestbBank
MultiplebChoice
1. Thebmajoritybofbmedicationsbavailablebtodaybactbonbwhichbsuperfamilybofbcellularb
membranebreceptor?
A. Ligand-gatedbionbchannel
B. G-protein-coupledbreceptor
C. Receptorbtyrosinebkinase
D. Nuclearbhormonebreceptor
E. Cytokinebreceptor
ANS:bB.bThebmajoritybofbdrugsbavailablebactbonbG-protein-coupledbreceptors.
2. Nalbuphineb isbanbeffectivebpainbrelieverbbecausebofbitsbactivitybatbmu-
opioidbreceptors.bHowever,bifbgivenbtobabpatientbwhobhasbrecentlybreceivedbmorphineb(whic
hbalsobaffectsbmu-
opioidbreceptors)bforbpostoperativebpain,bnalbuphinebcanbworsenbhisborbherbpain.bThusbnalb
uphinebisbsaidbtobhavebwhatbkindbofbactivitybatbmu-opioidbreceptors?
A. Fullbagonist
B. Partialbagonist
C. Competitivebantagonist
D. Non-competitivebantagonist
E. Allostericbmodifier
ANS:bB.bNalbuphinebisbabpartialbagonistbatbopioidbreceptors.
,Wecker: Brody’s Human Pharmacology, 5th Edition
b b b b b
Chapterb02:bPharmacokinetics:bAbsorption,bDistribution,bMetabolism,bandbElimination
TestbBank
MultiplebChoice
1. WhichbofbthebfollowingbfeaturesbofbabdrugbwouldbenhancebitsbuptakebinbthebGIbtract?
A. Polar
B. Waterbsoluble
C. Ionized
D. Lowbmolecularbweight
E. Lowbconcentrationbgradient
ANS:bD.bOfbtheboptionsbgiven,bonlybablowbmolecularbweightbwillbincreasebuptakebofbabdrugb
bybthebGIbtract.
2. Whichborganbcontainsbpredominantlybtightbintercellularbjunctions,btherebybrestrictingbi
tsbuptakebofbdrugs?
A. Kidney
B. Liver
C. Brain
D. Heart
E. Lungs
ANS:bC.bThebbrainbcontainsbtightbintercellularbjunctions,bformingbtheb“blood-
brainbbarrier.”
3. Drugsbcommonlybundergoballbofbthebfollowingbtypesbofbmetabolismbinbthebliverb
EXCEPTbFOR:
A. Polymerization
B. Conjugation
C. Oxidation
D. Reduction
E. Hydrolysis
ANS:bA.bPolymerizationbisbnotbabcommonbprocessbbybwhichbdrugsbarebhepaticallybmetaboliz
ed.
4. Whichborganbcontainsbpredominantlybtightbintercellularbjunctions,btherebybrestrictingbi
tsbuptakebofbdrugs?
A. Kidney
, B. Liver
C. Brain
D. Heart
E. Lungs
ANS:bC.bThebbrainbcontainsbtightbintercellularbjunctions,bformingbtheb“blood-
brainbbarrier.”
5. Drugsbcommonlybundergoballbofbthebfollowingbtypesbofbmetabolismbinbthebliverb
EXCEPTbFOR:
A. Polymerization
B. Conjugation
C. Oxidation
D. Reduction
E. Hydrolysis
ANS:bA.bPolymerizationbisbnotbabcommonbprocessbbybwhichbdrugsbarebhepaticallybmetaboliz
ed.
b b b b b
Chapterb01:bPharmacodynamics:bReceptorsbandbConcentration-ResponsebRelationships
TestbBank
MultiplebChoice
1. Thebmajoritybofbmedicationsbavailablebtodaybactbonbwhichbsuperfamilybofbcellularb
membranebreceptor?
A. Ligand-gatedbionbchannel
B. G-protein-coupledbreceptor
C. Receptorbtyrosinebkinase
D. Nuclearbhormonebreceptor
E. Cytokinebreceptor
ANS:bB.bThebmajoritybofbdrugsbavailablebactbonbG-protein-coupledbreceptors.
2. Nalbuphineb isbanbeffectivebpainbrelieverbbecausebofbitsbactivitybatbmu-
opioidbreceptors.bHowever,bifbgivenbtobabpatientbwhobhasbrecentlybreceivedbmorphineb(whic
hbalsobaffectsbmu-
opioidbreceptors)bforbpostoperativebpain,bnalbuphinebcanbworsenbhisborbherbpain.bThusbnalb
uphinebisbsaidbtobhavebwhatbkindbofbactivitybatbmu-opioidbreceptors?
A. Fullbagonist
B. Partialbagonist
C. Competitivebantagonist
D. Non-competitivebantagonist
E. Allostericbmodifier
ANS:bB.bNalbuphinebisbabpartialbagonistbatbopioidbreceptors.
,Wecker: Brody’s Human Pharmacology, 5th Edition
b b b b b
Chapterb02:bPharmacokinetics:bAbsorption,bDistribution,bMetabolism,bandbElimination
TestbBank
MultiplebChoice
1. WhichbofbthebfollowingbfeaturesbofbabdrugbwouldbenhancebitsbuptakebinbthebGIbtract?
A. Polar
B. Waterbsoluble
C. Ionized
D. Lowbmolecularbweight
E. Lowbconcentrationbgradient
ANS:bD.bOfbtheboptionsbgiven,bonlybablowbmolecularbweightbwillbincreasebuptakebofbabdrugb
bybthebGIbtract.
2. Whichborganbcontainsbpredominantlybtightbintercellularbjunctions,btherebybrestrictingbi
tsbuptakebofbdrugs?
A. Kidney
B. Liver
C. Brain
D. Heart
E. Lungs
ANS:bC.bThebbrainbcontainsbtightbintercellularbjunctions,bformingbtheb“blood-
brainbbarrier.”
3. Drugsbcommonlybundergoballbofbthebfollowingbtypesbofbmetabolismbinbthebliverb
EXCEPTbFOR:
A. Polymerization
B. Conjugation
C. Oxidation
D. Reduction
E. Hydrolysis
ANS:bA.bPolymerizationbisbnotbabcommonbprocessbbybwhichbdrugsbarebhepaticallybmetaboliz
ed.
4. Whichborganbcontainsbpredominantlybtightbintercellularbjunctions,btherebybrestrictingbi
tsbuptakebofbdrugs?
A. Kidney
, B. Liver
C. Brain
D. Heart
E. Lungs
ANS:bC.bThebbrainbcontainsbtightbintercellularbjunctions,bformingbtheb“blood-
brainbbarrier.”
5. Drugsbcommonlybundergoballbofbthebfollowingbtypesbofbmetabolismbinbthebliverb
EXCEPTbFOR:
A. Polymerization
B. Conjugation
C. Oxidation
D. Reduction
E. Hydrolysis
ANS:bA.bPolymerizationbisbnotbabcommonbprocessbbybwhichbdrugsbarebhepaticallybmetaboliz
ed.
