TEST BANK DAVIS’S DRUG GUIDE FOR NURSES 17TH VALLERAND 2

Medication List: f




Shae:

Seroquel:

DrugfClassification GenericfName TradefName
f Atypicalf antipsychotic quetiapine seroquel;fSEROquel;fSERO
quelfXR


Route/Frequency: Onset:fRapidf(Drugs.com)
fOralf(PO) Peak:f1.5fhoursf(Drugs.com)
Duration:f?f(half-lifef=f6fhours,fperfDrugs.com)

MechanismfoffAction: f Serotoninf(5HT2)fandfdopaminef(D2)fantagonistf[F&P,f2021,fp.
f 1110]
f



Indications/Uses: Bipolarfdisorderf(withfmanicfepisodes);fschizophrenia;fdepres
f

sivefdisorderf(p.f1110,f1131);
f



Interactions: Cimetadine;fketoconazole;fitraconazole;ffluconazole;ferythro
mycin;fCYP34Afinhibitorsf(increasef(potentiate)feffectsfoffSero
quel).fPhenytoinfandfthioridazinef(decreasefeffectsfoffSeroque
l.fAntihypertensivesf(increasedfhypotension).fAlcohol/CNSfde
pressantsf(increasedfCNSfdepression).fConcomitantfusefwithf
otherfmood-
stabilizingfagentsfmayfresultfinflevodopafandfdopaminefagonis
tfinhibitionforfdecrease.

AdversefEffects: fDrowsiness;fdizziness;fdecreasedfvision;ffatigue;fweightfgain;
ftachycardia;fhypertension;forthostaticfhypotension;fheadache
;fagitation;fhyperlipidemia;fxerostomia;fconstipation;fincrease
dfappetitef(Frandsenf&fPennington,f2021,fp.f1110,f1131).
fEPS,f NMSf (neurolepticf malignantf syndrome);f agranulocytosi

s;fanticholinergicfeffects;fsomnolence

,Contraindications/ Dementia-
f

Precautions: relatedfpsychosesf(p.f1110);fpregnancyfand/orfbreastfeeding;f
hepaticfimpairmentf(Seroquelfisfmetabolizedfinfthefliver)
f



MedicationfAdministrationf Administerfwithoutffoodf(orfwithffoodfcontainingflessfthanf300fc
f

Specifics: alories)f(F&P,f2021,fp.f1110).

QSENfAlerts/BlackfBoxfWar fAf2019fstudyffoundfthatfSeroquelftreatmentfhadftofbefterminat
nings: edfmoreffrequentlyfthanfotherfsecond-
generationfantipsychoticsf(Frandsenf&fPennington,f2021,fp.f1
131).

MonitoringfParameters/ Monitorfforfsuicidalfideation;fmonitorfforftherapeuticfeffects;fmo
Interventions nitorfforfadversefeffects

PatientfTeachingfGuideline Infwomenfoffchildbearingfage,fusefadequatefcontraceptionftofa
f

s: voidfbecomingfpregnantf(Drugs.com)
f


https://www.drugs.com/pro/seroquel.html


Lithium:

DrugfClassification GenericfName TradefName
fMood-stabilizingf agent; Lithiumfcarbonate Lithium;fLithobid
Antimanicfagent

Route/Frequency: Onset:
fOralf(PO) Peak:f1-3fhoursf(Frandsenf&fPennington,f2020,fp.f1108)
Duration:f5-7fdaysf(Frandsenf&fPennington,f2020,fp.f1108)

MechanismfoffAction: fUnknownf(MorganfandfTownsend,f2020,fp.f67);fdrugfisfnotfme
tabolizedfatfall,fonlyfexcreted.
f



Indications/Uses: f Bipolarfdisorder
f




Interactions: Anesthetics;fneuromuscular-
blockingfdrugsf(Frandsenf&fPennington,f2020,fp.f1109);falcoh
olfandfdiureticsf(increasefdehydrationfandfriskfofftoxicity);fACEf
inhibitors,fangiotensinfIIfblockers,findomethacin,fNSAIDSf(riskf
offtoxicity);fSSRIsf(adversefeffects);ftheophyllinef(increasesfex
cretion)f(F&P,fp.f1110)

,AdversefEffects: “metallicftaste,fhandftremors,fnausea,fpolyuria,fpolydipsia,fdia
f

rrhea,fmuscularfweakness,ffatigue,fedema,fandfweightfgain”f(
F&P,fp.f1110).fLithiumftoxicity.f
f



Contraindications/ Usefwithfcautionfinfpatientsfwithfrenalfimpairment;fcontraindic
f

Precautions: atedfinfpregnancy
f



MedicationfAdministrationf Administerfwithffoodf(F&P,fp.f1110);fmaxfdosagefisf1800mgfinf
f

Specifics: adults;fdosagefisfusuallyf300mgfinfchildrenfoverf6fyears.

QSENfAlerts/BlackfBoxfWar fCloselyfmonitorfserumflithiumflevels;finteractionsfwithfanesthe
nings: ticsfandfneuromuscularfblockingfagentsfmayfcausefprolongedf
effectsfoffthosefdrugsf(Frandsenf&fPennington,f2020,fp.f1109).
fTeratogenic.f




MonitoringfParameters/fInt Nursesfshould:fassessfforfsidefeffects,fassessfforftherapeu
erventions ticfeffectiveness,fmonitorfforfserumflithiumflevelsf(infthefmo
rningsf12fhoursfafterfpreviousfdose),fmonitorfforfsignsfandf
symptomsfofflithiumftoxicity,fmonitorfintakefandfoutputf(esp
eciallyfinfregardftofwaterfandfsodium),fadministerfthefmedic
ation,fandfprovidefclientfeducationfwithfthefendfgoalfoffself-
maintenance.

■ffForfacutefmania:f1.0ftof1.5fmEq/L

■ffForfmaintenance:f0.6ftof1.2fmEq/L

Obtainfbaselinefelectrolytesfandfconfirmffunctioningfoffcardiac
,frenalfsystemsfandfthyroidf(p.f1110).



PatientfTeachingfGuideline Usefeffectivefcontraceptivefmethodsftofavoidfpregnancy
ff

s: fDof notftakefdiureticsforf usef alcohol

Stayfhydrated




Benadryl:

DrugfClassification GenericfName TradefName
diphenhydramine;fdiphenhydr Benadryl
AMINE

, Firstfclassfantihistamine;fanti
f

cholinergicfantiparkinsonianfa
gents

Route/Frequency: Onset:frapid
fOralf(PO)f(alsof asfIV,f IMfform Peak:f1fhour
ulations) Duration:f4-6fhours

MechanismfoffAction: f AntagonistfoffH1freceptor
f




Indications/Uses: fAllergicfreactions;fmotionfsickness;fantiparkinsonism;finsomn
ia
f



Interactions: AdditivefeffectsfonfCNSfdepressantsf(includingfalcohol);fadditi
vefanticholinergicfeffectsfwhenftakenfwithfMAOIsf(Drugs.com)

AdversefEffects: fSedationf(Somnolence),fdizziness,fandfotherfCNSfdepression
;fepigastricfdistress;fthickfbronchialfexcretionsf(Drugs.com);finf
pediatrics,fexcitationforfdecreasedfalertnessfmayfalsofoccurf(D
rugs.com)

Contraindications/ Contraindicated:fNeonatesfandfinfants;fwomenfwhofarefbrea
f

Precautions: stfeeding.
W/fcautionfinfthosefwhofhavefglaucoma,fpepticfulcers,fpylorod
uodenalfobstructions,fprostaticfhypertrophy,fbladderfneckfobst
ructionf(Drugs.com)
f



MedicationfAdministrationf fMaxfdosagefisf300mgfinfpediatricsfandf400mgfinfadultsf(Drugs
Specifics: .com)

QSENfAlerts/BlackfBoxfWar f Overdosefisfpossiblefandfmayfleadftoftoxicity
nings:

MonitoringfParameters/fInt Monitorfforftherapeuticfbenefitsf(suchfasfalleviationfoffallergicfr
erventions: eactionfsymptoms);fmonitorfforfsidefeffectsfandflevelfoffsedatio
n
Mayfinterferefwithfresultsfoffallergenftesting
PerfStatPearls,fbaselinefserumfcreatininefisfneededfinfpedsfpa
tients

PatientfTeachingfGuideline f Dofnotfdriveforfoperatefmachineryfunlessfyoufknowfeffect;f
f
s: