Test Bank For Basic Immunology Functions and Disorders of the Immune System 5th Edition By Abul Abbas, Andrew Lichtman, Shiv Pillai 9780323390828 Chapter 1-12 Complete Guide .2

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dition: Abul K. Abbas b b b




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3. Abpreviouslybhealthyb8-year-
oldbboybisbinfectedbwithbanbupperbrespiratorybtractbvirusbforbthebfirstbtime.bDuringbthebfirstb
fewbhoursbofbinfection,bwhichbonebofbthebfollowingbeventsboccurs?
A. Thebadaptivebimmunebsystembrespondsbrapidlybtobthebvirusbandbkeepsbthebviralbi
nfectionbunderbcontrol.
B. Thebinnatebimmunebsystembrespondsbrapidlybtobthebviralbinfectionbandbkeepsbtheb
viralbinfectionbunderbcontrol.
C. Passivebimmunitybmediatedbbybmaternalbantibodiesblimitsbthebspreadbofbinfection.
D. BbandbTblymphocytesbrecognizebthebvirusbandbstimulatebthebinnatebimmunebr
esponse.
E. Thebvirusbcausesbmalignantbtransformationbofbrespiratorybmucosalbepithelialbcells,b
andbthebmalignantbcellsbarebrecognizedbbybthebadaptivebimmunebsystem.

ANS:bB
Thebinnatebimmunebresponsebtobmicrobesbdevelopsbwithinbhoursbofbinfection,bwellbbeforebt
hebadaptivebimmunebresponse.bBbandbTblymphocytesbarebcomponentsbofbthebadaptivebimmu
nebresponse,bandbtheybwouldbnotbbebablebtobrespondbtobabnewlybencounteredbvirusbbeforebthe
binnatebimmunebresponse. bAnb8-year-

oldbboybwouldbnoblongerbhavebmaternalbantibodiesbfrombtransplacentalbpassivebtransferbandb
isbunlikelybtobbebbreast-
feeding,bwhichbisbanotherbpotentialbsourcebofbmaternalbantibodies.bMalignantbtransformatio
nbtakesbmonthsborbyearsbtobdevelop.

4. Whichbofbthebfollowingbisbabuniquebpropertybofbthebadaptivebimmunebsystem?
A. Highlybdiversebrepertoirebofbspecificitiesbforbantigens
B. Self-nonselfbdiscrimination
C. Recognitionbofbmicrobialbstructuresbbybbothbcell-associatedbandbsolublebreceptors
D. Protectionbagainstbviralbinfections
E. Responsesbthatbhavebthebsamebkineticsbandbmagnitudebonbrepeatedbexposurebtobthebs
amebmicrobe

ANS:bA
HighlybdiversebrepertoiresbofbspecificitiesbforbantigensbarebfoundbonlybinbTbandbBblymphocy
tes,bwhichbarebthebcentralbcellularbcomponentsbofbthebadaptivebimmunebsystem.bBothbthebinn
atebandbthebadaptivebimmunebsystemsbusebcell-
associatedbandbsolublebreceptorsbtobrecognizebmicrobes,bdisplaybsomebdegreebofbself-
nonselfbdiscrimination,bandbprotectbagainstbviruses.bOnbrepeatedbexposurebtobthebsamebmicr
obe,bthebadaptivebimmunebresponsebbecomesbmorebrapidbandbofbgreaterbmagnitude;bthisbisbt
hebmanifestationbofbmemory.

5. AntibodiesbandbTblymphocytesbarebthebrespectivebmediatorsbofbwhichbtwobtypesbofbi
mmunity?
A. Innatebandbadaptive
B. Passivebandbactive
C. Specificbandbnonspecific
D. Humoralbandbcell-mediated
E. Adultbandbneonatal



Copyrightb©b2014,b2011,b2009,b2006,b2004,b2001bbybSaunders,banbimprintbofbElsevierbInc.

,TestbBank 1-3


ANS:bD
BothbBbandbTblymphocytesbarebprincipalbcomponentsbofbadaptivebimmunity.bBblymphocyte
sbproducebantibodies,bwhichbarebthebrecognitionbandbeffectorbmoleculesbofbhumoralbimmune
bresponsesbtobextracellularbpathogens.bTbcellsbrecognizebandbpromoteberadicationbofbintracell

ularbpathogensbinbcell-
mediatedbimmunity.bPassivebandbactivebimmunitybbothbcanbbebmediatedbbybeitherbBborbTbly
mphocytes.bSpecificbimmunitybisbanotherbtermbforbadaptivebimmunity.bBothbBbandbTblymph
ocytesbparticipatebinbadultbadaptivebimmunitybbutbarebstillbdevelopingbinbthebneonatalbperiod
.

6. Abstandardbtreatmentbofbanimalbbitebvictims,bwhenbtherebisbabpossibilitybthatbthebanimalb
wasbinfectedbwithbthebrabiesbvirus,bisbadministrationbofbhumanbimmunoglobulinbpreparation
sbcontainingbanti–
rabiesbvirusbantibodies.bWhichbtypebofbimmunitybwouldbbebestablishedbbybthisbtreatment?
A. Activebhumoralbimmunity
B. Passivebhumoralbimmunity
C. Activebcell-mediatedbimmunity
D. Passivebcell-mediatedbimmunity
E. Innatebimmunity

ANS:bB
Humoralbimmunitybisbmediatedbbybantibodies.bThebtransferbofbprotectivebantibodiesbmadebb
yboneborbmorebindividualsbintobanotherbindividualbisbabformbofbpassivebhumoral
immunity.bActivebimmunitybtobanbinfectionbdevelopsbwhenbanbindividual’sbownbimmunebsy
stembrespondsbtobthebmicrobe.bCell-
mediatedbimmunitybisbmediatedbbybTblymphocytes,bnotbantibodies,bandbinnatebimmunitybisb
notbmediatedbbybeitherbantibodiesborbTblymphocytes.

7. Atb15bmonthsbofbage,babchildbreceivedbabmeasles-mumps-
rubellabvaccineb(MMR).bAtbageb22,bshebisblivingbwithbabfamilybinbMexicobthatbhasbnotbbee
nbvaccinatedbandbshebisbexposedbtobmeasles.bDespitebthebexposure,bshebdoesbnotbbecomebi
nfected.bWhichbofbthebfollowingbpropertiesbofbthebadaptivebimmunebsystembisbbestbillustra
tedbbybthisbscenario?
A. Specificity
B. Diversity
C. Specialization
D. Memory
E. Nonreactivitybtobself

ANS:bD
Protectionbagainstbinfectionsbafterbvaccinationbisbduebtobimmunologicbmemorybofbthebadapti
vebimmunebsystem.bMemorybisbmanifestedbasbabmorebrapidlybdevelopingbandbvigorousbresp
onsebonbrepeatbexposurebtobanbantigenbcomparedbwithbthebfirstbexposure.bSpecificitybandbdiv
ersitybarebpropertiesbrelatedbtobthebrangebofbantigenicbstructuresbrecognizedbbybthebimmuneb
system,bandbspecializationbisbthebabilitybofbthebadaptivebimmunebsystembtobusebdistinctbeffec
torbmechanismsbforbdistinctbinfections.

8. Abvaccinebadministeredbinbthebautumnbofbonebyearbmaybprotectbagainstbthebprevalentbs
trainbofbinfluenzabvirusbthatboriginatedbinbHongbKongbthatbsamebyear,bbutbitbwillbnot

, Copyrightb©b2014,b2011,b2009,b2006,b2004,b2001bbybSaunders,banbimprintbofbElsevierbInc.