12/16/23,c10:25cAM ImmunologycTestcBankc-cAllcCorrectlycanswered
Immunology Test Bank c c
Thecgerminalccenterscfoundcinctheccorticalcregioncofclymphcnodescandcthecperipheralcregi
oncofcspleniccperiarteriolarclymphaticctissue:c-
ccontainsclargecpopulations cofcB clymphocytes cand cplasma ccells
BalancecbetweencTH1candcTH2ccellcactivationcdeterminescoutcomecofcintracellularci
nfections.cThus,cinccasecofcMycobacteriumclepraecinfection:c-
ctuberculoid cleprosy cwillcoccurcin cpatientscwith cacprominentcTH1cresponse
ThecinitiationcofcTccellcresponsescrequirescmultiplecreceptorsconcthecTccellscrecogni
zingcligandsconcAPCs.cThecMHCcmoleculeclocatedcaroundcthecpeptide-
cbinding ccleftciscrecognized cby cthe:c -cCD4corcCD8 cmolecules
Thecedemacoccurringcincthecinflammatorycprocessciscthecresultcofcallcthecfollowingcf
actorscEXCEPT:c-cneuralcimpulsecbycthecsympatheticcsystemcandcvasoconstriction
Toll-LikecReceptorsc(TLR):c-crecognizecpathogen-
associatedcmolecularcpatternsc(PAMPs)concselectivecmicroorganisms
ThecinitiationcofcTccellcresponsescrequirescmultiplecreceptorsconcthecTccellscrecogni
zingcligandsconcAPCs.cThecTccellcreceptorctransductioncmolecule(s)cis(are)cconducte
dcby:c-cCD3candcζcmolecules
Whichcofcthecfollowingciscconsideredcacprimaryclymphoidcorgan?c-cthymus
ImmediatecactivationcofcthecBclymphocytescfollowingccontactcwithcthecantigencinvol
vescallcofcthecfollowingcmoleculescEXCEPT:c-cMHCcclasscIIcmolecules
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,12/16/23,c10:25cAM ImmunologycTestcBankc-cAllcCorrectlycanswered
Immunologiccmemorycreferscto:c-
cchangescincadaptive cimmune cresponses cwith csubsequentcencounters cwith cantigen
Both,cnaivecmatureceffectorcTclymphocytescmigratecdifferentlycinctheirclives.cNaivec
Tccellscexpresscwhichcadhesioncmoleculectocmediatectheircmigrationcintoclymphcno
descthroughcspecializedcvesselsccalledchighcendothelialcvenuesc(HEVs)?c-cL-
selectin
ThecmaincconsequencescofccomplementcactivationcarecallcofcthecfollowingcEXCEPT:
-cproducingc2ndcsignalcforcmacrophagecactivation
'LangerhanscCells'cwhichcplaycacrolecincthecimmunecsystemcare:c-
cdendritic ccellsclocated cmainly cin cthecepidermis
Allcofcthecfollowingccellscresultscincthecgerminalccentercreactioncofcthecfolliclesc(Bclymph
ocyteczone)cEXCEPT:c-cshort-livedcplasmaccells
Thecantigencrecognition concthecTccellsciscmediatedcby:c-
cthecVariable c(v)cregions cofcα cand cβ cchains
ThecT-cellcreceptor:c-crecognizescantigencfragmentscviacthecαcandcβcchains
Accordingctocthecclonalcselectionchypothesis,cwhichcofcthecfollowingciscCORRECT?
-
cClones cofclymphocytes cspecific cforcantigenscdevelop cpriorcto cexposure ctocthe cantige
ns
WhichcofcthecfollowingcbestcdescribescthecT-dependentcantibodycresponse?c-
cIT ciscthecresponse cofcfollicularcB clymphocytes cto cacprotein cantigen cand ccharacterize
dcbycisotope-
switched,chighcaffinitycantibodies;cmemorycBccells,clongclivedcplasmaccells
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, 12/16/23,c10:25cAM ImmunologycTestcBankc-cAllcCorrectlycanswered
MHCcclasscIIcmoleculesccontain:c-cOnecαcchaincandconecβcchain
ThecinflammatoryccytokinescwillccausecLangerhansccellscincthecepidermisctocperform
callcofcthe cfollowing cEXCEPT:c-
cantigen cpresentation cto cthecT ccellscin cthecfollicles cofctheclymph cnodes
Thecphasescandcordercofcthecspecificcorcacquiredcimmunecresponsescare:c-
crecognition cphase;cactivation cphase;ceffectorcphase;chomeostasis cphase;cmemory cphase
AcnaivecCD4+cTccellcmaycdifferentiatecintocsubsetscthatcproducecdifferentccytokinesc
thatcrecruitcandcactivatecdifferentccellctypes.cThecIFN-γciscproducedcmainlycby:c-
cCD4+cT ccellcTH1csubset
TH1csubsetceffectorccellscthatcaidcinccellcmediatedcimmunecresponsecactivatecthecmacrop
hagecandcBclymphocytescby:c-cCD40L-CD40cinteractioncandcIFN-γ
Thecdiversitycofcantigencreceptorscproducedcbycthecusecofcdifferentccombinationsco
fcV,cD,candcJcgenecsegmentscincdifferentcclonescofclymphocytesciscthecresultcof:c-
cboth ccombinatorialcdiversity cand cjunctionalcdiversity
AllcofcthecfollowingcstatementscaboutcthecB-cellcantigencreceptorcarectruecEXCEPT:c-
recognizescantigencfragmentscviacthecαcandcβcchains
Acstandardctreatmentcofcanimalcbitecvictims,cwhencthereciscacpossibilitycthatcthecani
malcwascinfectedcwithcrabiescvirus,ciscadministrationcofchumancimmunoglobulin cpre
parationsccontainingcanti-
rabiescviruscantibodies.cWhichctypecofcimmunitycwouldcbecestablishedcbycthisctreatm
ent?c-cpassivechumoralcimmunity
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Immunology Test Bank c c
Thecgerminalccenterscfoundcinctheccorticalcregioncofclymphcnodescandcthecperipheralcregi
oncofcspleniccperiarteriolarclymphaticctissue:c-
ccontainsclargecpopulations cofcB clymphocytes cand cplasma ccells
BalancecbetweencTH1candcTH2ccellcactivationcdeterminescoutcomecofcintracellularci
nfections.cThus,cinccasecofcMycobacteriumclepraecinfection:c-
ctuberculoid cleprosy cwillcoccurcin cpatientscwith cacprominentcTH1cresponse
ThecinitiationcofcTccellcresponsescrequirescmultiplecreceptorsconcthecTccellscrecogni
zingcligandsconcAPCs.cThecMHCcmoleculeclocatedcaroundcthecpeptide-
cbinding ccleftciscrecognized cby cthe:c -cCD4corcCD8 cmolecules
Thecedemacoccurringcincthecinflammatorycprocessciscthecresultcofcallcthecfollowingcf
actorscEXCEPT:c-cneuralcimpulsecbycthecsympatheticcsystemcandcvasoconstriction
Toll-LikecReceptorsc(TLR):c-crecognizecpathogen-
associatedcmolecularcpatternsc(PAMPs)concselectivecmicroorganisms
ThecinitiationcofcTccellcresponsescrequirescmultiplecreceptorsconcthecTccellscrecogni
zingcligandsconcAPCs.cThecTccellcreceptorctransductioncmolecule(s)cis(are)cconducte
dcby:c-cCD3candcζcmolecules
Whichcofcthecfollowingciscconsideredcacprimaryclymphoidcorgan?c-cthymus
ImmediatecactivationcofcthecBclymphocytescfollowingccontactcwithcthecantigencinvol
vescallcofcthecfollowingcmoleculescEXCEPT:c-cMHCcclasscIIcmolecules
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,12/16/23,c10:25cAM ImmunologycTestcBankc-cAllcCorrectlycanswered
Immunologiccmemorycreferscto:c-
cchangescincadaptive cimmune cresponses cwith csubsequentcencounters cwith cantigen
Both,cnaivecmatureceffectorcTclymphocytescmigratecdifferentlycinctheirclives.cNaivec
Tccellscexpresscwhichcadhesioncmoleculectocmediatectheircmigrationcintoclymphcno
descthroughcspecializedcvesselsccalledchighcendothelialcvenuesc(HEVs)?c-cL-
selectin
ThecmaincconsequencescofccomplementcactivationcarecallcofcthecfollowingcEXCEPT:
-cproducingc2ndcsignalcforcmacrophagecactivation
'LangerhanscCells'cwhichcplaycacrolecincthecimmunecsystemcare:c-
cdendritic ccellsclocated cmainly cin cthecepidermis
Allcofcthecfollowingccellscresultscincthecgerminalccentercreactioncofcthecfolliclesc(Bclymph
ocyteczone)cEXCEPT:c-cshort-livedcplasmaccells
Thecantigencrecognition concthecTccellsciscmediatedcby:c-
cthecVariable c(v)cregions cofcα cand cβ cchains
ThecT-cellcreceptor:c-crecognizescantigencfragmentscviacthecαcandcβcchains
Accordingctocthecclonalcselectionchypothesis,cwhichcofcthecfollowingciscCORRECT?
-
cClones cofclymphocytes cspecific cforcantigenscdevelop cpriorcto cexposure ctocthe cantige
ns
WhichcofcthecfollowingcbestcdescribescthecT-dependentcantibodycresponse?c-
cIT ciscthecresponse cofcfollicularcB clymphocytes cto cacprotein cantigen cand ccharacterize
dcbycisotope-
switched,chighcaffinitycantibodies;cmemorycBccells,clongclivedcplasmaccells
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, 12/16/23,c10:25cAM ImmunologycTestcBankc-cAllcCorrectlycanswered
MHCcclasscIIcmoleculesccontain:c-cOnecαcchaincandconecβcchain
ThecinflammatoryccytokinescwillccausecLangerhansccellscincthecepidermisctocperform
callcofcthe cfollowing cEXCEPT:c-
cantigen cpresentation cto cthecT ccellscin cthecfollicles cofctheclymph cnodes
Thecphasescandcordercofcthecspecificcorcacquiredcimmunecresponsescare:c-
crecognition cphase;cactivation cphase;ceffectorcphase;chomeostasis cphase;cmemory cphase
AcnaivecCD4+cTccellcmaycdifferentiatecintocsubsetscthatcproducecdifferentccytokinesc
thatcrecruitcandcactivatecdifferentccellctypes.cThecIFN-γciscproducedcmainlycby:c-
cCD4+cT ccellcTH1csubset
TH1csubsetceffectorccellscthatcaidcinccellcmediatedcimmunecresponsecactivatecthecmacrop
hagecandcBclymphocytescby:c-cCD40L-CD40cinteractioncandcIFN-γ
Thecdiversitycofcantigencreceptorscproducedcbycthecusecofcdifferentccombinationsco
fcV,cD,candcJcgenecsegmentscincdifferentcclonescofclymphocytesciscthecresultcof:c-
cboth ccombinatorialcdiversity cand cjunctionalcdiversity
AllcofcthecfollowingcstatementscaboutcthecB-cellcantigencreceptorcarectruecEXCEPT:c-
recognizescantigencfragmentscviacthecαcandcβcchains
Acstandardctreatmentcofcanimalcbitecvictims,cwhencthereciscacpossibilitycthatcthecani
malcwascinfectedcwithcrabiescvirus,ciscadministrationcofchumancimmunoglobulin cpre
parationsccontainingcanti-
rabiescviruscantibodies.cWhichctypecofcimmunitycwouldcbecestablishedcbycthisctreatm
ent?c-cpassivechumoralcimmunity
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