NR293 Pharmacology for Nursing Practice Week 4
Concepts
Pharmacology For Nursing Practice (Chamberlain
University)
, Week 4 Concepts: Clotting
Coagulation Modifiers
Prepare: Coagulation Modifiers
Coagulation Modifiers
Coagulation modifiers are a group of medications that both promote and prevent clot formation as well as lysi
a preformed clot and reversing the action of anticoagulants.
Warfarin
Warfarin is an anticoagulant medication whose mechanism of action is to prevent clot formation by inhibiting
particular clotting factors.
Coagulation Modifier Drugs
Coagulation modifier drugs is a class of medication that includes medications?
hepari
n
aspirin
acetaminophen
warfarin
Self Check: Hemostasis Review
Coagulation Cascade System
The coagulation cascade system is triggered by an injury to a blood vessel, which then triggers either an
intrinsic or an extrinsic pathway of intricate steps, each step triggering the next when clotting factors are/is
activated. The ultimate result of this system is a large concentration of fibrin.
Reverse of the Coagulation Process
The reverse of the coagulation process is the fibrinolytic system. Fibrinolysis is the breakdown of thrombi. This
an important part of hemostasis in order to prevent excessive coagulation, blocked blood vessels, or mobilized
thrombi called an embolus.
Self Check: Coagulation Modifier Drugs
Coagulation Modifiers
The coagulation modifier drugs are broken down into several subclasses or categories based on their hemostasis
reversal or promotion action. Which items are mechanisms of action for this class of drug? Select all that apply.
Thrombus
prevention
Thrombus
mobilization
Lysing of a preformed
thrombus Anticoagulation
reversal Thrombus
promotion Antiplatelet
reversal
Self Check: Mechanism of Action
Mechanism of Action
Which one of these coagulation modifier drugs has a mechanism of action that is to lyse a thrombus that has
already formed? Match it to its subclass.
Medication Subclass
,Mechanism of Alteplase Thrombolytic
Action
Reversal Drug
Which of these medications i s a coagulation modifier whose subclass is a reversal dru g? Select all that apply.
aminocaproic acid
apixaban
, protamine
sulfate vitamin
K
Reflect: Coagulation Modifiers
Antifibrinolytics
What is another term for antifibrinolytics?
Antithrombotics
Antiplatelets
Hemorheologics
Hemostatics
Promoting Coagulation
A coagulation modifier drug whose mechanism of action is to promote coagulation of the blood is called a(n)
and is used to .
antifibrinolytic, manage excessive
bleeding anticoagulant, prevent clot
formation thrombolytic, lyse clots that
have already formed antiplatelet, interfere
with platelet function
Anticoagulants
What is another term for anticoagulant?
Hemostatics
Antiplatelets
Hemorheologics
Antithrombotics
Antifibrinolytics
Coagulation Modifier Drugs and Subclasses
Match the coagulation modifier drug’s subclass to the correct medications. Note: Several of the subclasses have
more than one medication listed as correct choices.
Anticoagulants ● Enoxaparin
● Heparin
● Warfarin
● Dabigatran
● etexilateapixaban
Antiplatelets ● clopidogrel bisulfate
● abciximab
Thrombolytics ● alteplase
Antifibrinolytics ● aminocaproic acid
Hemorheologics ● pentoxifylline
Reversal Drugs ● coagulation factor Xa (recombinant)
● idarucizumab
● protamine sulfate
● phytonadione
Reversal and Coagulation Modifier Drugs
Choose the correct word(s) from the drop-down list to complete the following statements regarding reversal drugs.
Protamine sulfate is the reversal drug for heparin.
Concepts
Pharmacology For Nursing Practice (Chamberlain
University)
, Week 4 Concepts: Clotting
Coagulation Modifiers
Prepare: Coagulation Modifiers
Coagulation Modifiers
Coagulation modifiers are a group of medications that both promote and prevent clot formation as well as lysi
a preformed clot and reversing the action of anticoagulants.
Warfarin
Warfarin is an anticoagulant medication whose mechanism of action is to prevent clot formation by inhibiting
particular clotting factors.
Coagulation Modifier Drugs
Coagulation modifier drugs is a class of medication that includes medications?
hepari
n
aspirin
acetaminophen
warfarin
Self Check: Hemostasis Review
Coagulation Cascade System
The coagulation cascade system is triggered by an injury to a blood vessel, which then triggers either an
intrinsic or an extrinsic pathway of intricate steps, each step triggering the next when clotting factors are/is
activated. The ultimate result of this system is a large concentration of fibrin.
Reverse of the Coagulation Process
The reverse of the coagulation process is the fibrinolytic system. Fibrinolysis is the breakdown of thrombi. This
an important part of hemostasis in order to prevent excessive coagulation, blocked blood vessels, or mobilized
thrombi called an embolus.
Self Check: Coagulation Modifier Drugs
Coagulation Modifiers
The coagulation modifier drugs are broken down into several subclasses or categories based on their hemostasis
reversal or promotion action. Which items are mechanisms of action for this class of drug? Select all that apply.
Thrombus
prevention
Thrombus
mobilization
Lysing of a preformed
thrombus Anticoagulation
reversal Thrombus
promotion Antiplatelet
reversal
Self Check: Mechanism of Action
Mechanism of Action
Which one of these coagulation modifier drugs has a mechanism of action that is to lyse a thrombus that has
already formed? Match it to its subclass.
Medication Subclass
,Mechanism of Alteplase Thrombolytic
Action
Reversal Drug
Which of these medications i s a coagulation modifier whose subclass is a reversal dru g? Select all that apply.
aminocaproic acid
apixaban
, protamine
sulfate vitamin
K
Reflect: Coagulation Modifiers
Antifibrinolytics
What is another term for antifibrinolytics?
Antithrombotics
Antiplatelets
Hemorheologics
Hemostatics
Promoting Coagulation
A coagulation modifier drug whose mechanism of action is to promote coagulation of the blood is called a(n)
and is used to .
antifibrinolytic, manage excessive
bleeding anticoagulant, prevent clot
formation thrombolytic, lyse clots that
have already formed antiplatelet, interfere
with platelet function
Anticoagulants
What is another term for anticoagulant?
Hemostatics
Antiplatelets
Hemorheologics
Antithrombotics
Antifibrinolytics
Coagulation Modifier Drugs and Subclasses
Match the coagulation modifier drug’s subclass to the correct medications. Note: Several of the subclasses have
more than one medication listed as correct choices.
Anticoagulants ● Enoxaparin
● Heparin
● Warfarin
● Dabigatran
● etexilateapixaban
Antiplatelets ● clopidogrel bisulfate
● abciximab
Thrombolytics ● alteplase
Antifibrinolytics ● aminocaproic acid
Hemorheologics ● pentoxifylline
Reversal Drugs ● coagulation factor Xa (recombinant)
● idarucizumab
● protamine sulfate
● phytonadione
Reversal and Coagulation Modifier Drugs
Choose the correct word(s) from the drop-down list to complete the following statements regarding reversal drugs.
Protamine sulfate is the reversal drug for heparin.
