Naplex 2025 – Pain Questions With All Correct Answers
Types of pain correct answers -nociceptive
pathophysiologic
Nociceptive pain occurs when correct answers -sensory nerves detect
tissue damage
Pathophysiologic pain is caused by correct answers -damage or
malfunctioning of the nervous system
Also called neuropathic pain
Conditions considered as pathophysiologic pain correct answers -
fibromyalgia
diabetic neuropathy
Pain level to treatment option correct answers -mild - 1-3 - Non opioid
+/- adjuvant
Mod - 4 - 6 - Opioid for mild/mod pain +/- non-opioid and/or adjuvant
Severe - 7 - 10 - Opioid for mod/severe pain +/- non-opioid and/or adjuvant
Acetaminophen function correct answers -reduces pain and fever as an
atipyretic, but does not have an anti-inflammatory effect
Possible inhibition of PG synthesis in the CNS
Acetaminophen formulations correct answers -Tylenol/ofirmev
infection/feverall suppository
+ hydrocodone - Norco/vicodin/lortab
+ oxycodone - endocet/percocet
+ codeine - tylenol #2/3/4
+ tramadol - Ultracet
+ butabital/caffeine - Fioricet
Maximum daily dose of APAP is correct answers -4000 mg/day frm all
sources
Pediatric APAP dosing correct answers -10-15 mg/kg q4-6 hours
max 5 doses per day
, APAP boxed warning correct answers -Hepatotoxicity associated with
doses >4g per day or use of multiple APAP containing products
APAP SE correct answers -severe skin rash including SJS/TEN
APAP safety correct answers -avoid the APAP abbreviation (lol)
The antidote for APAP overdose is correct answers -N-acetylcysteine
(NAC/Mucomyst/cetylev/acetadote)
NAC function correct answers -restores intracellular glutathione
available in both oral/IV
Rumack-matthew nomogram useds the serum APAP level and time of
ingestion to determine whether hepatotoxicity is likely and if NAC is needed
Non selective NSAIDs block the synthesis of correct answers -COX1/2
enzymes
COX-2 selective NSAIDs have lower GI risk because correct answers -COX-
1 protects the gastric mucosa
Aspirin irreversibly binds to correct answers -COX-1 which decreases the
formation of thromboxane A2, a component in platelet activation
All NSAIDs requires a ____ due to the risks associated with use correct
answers -MedGuide
NSAID GI risk correct answers -increased risk of bleeding and ulcerations
NSAIDs CV risk correct answers -increased risk of MI and stroke
NSAID use is CI in CABG surgery
-antiplatelet therapy such as aspirin is recommended insteqad
NSAIDs SE correct answers -Decrease renal blood flow to glomerulus,
caution in renal failure
Increased BP,avoid in uncontrolled HTN
Premature closure of the ductus arteriosus which can cause heart failure in
babies. Avoid using in 3rd trimester of pregnancy >30 weeks
Types of pain correct answers -nociceptive
pathophysiologic
Nociceptive pain occurs when correct answers -sensory nerves detect
tissue damage
Pathophysiologic pain is caused by correct answers -damage or
malfunctioning of the nervous system
Also called neuropathic pain
Conditions considered as pathophysiologic pain correct answers -
fibromyalgia
diabetic neuropathy
Pain level to treatment option correct answers -mild - 1-3 - Non opioid
+/- adjuvant
Mod - 4 - 6 - Opioid for mild/mod pain +/- non-opioid and/or adjuvant
Severe - 7 - 10 - Opioid for mod/severe pain +/- non-opioid and/or adjuvant
Acetaminophen function correct answers -reduces pain and fever as an
atipyretic, but does not have an anti-inflammatory effect
Possible inhibition of PG synthesis in the CNS
Acetaminophen formulations correct answers -Tylenol/ofirmev
infection/feverall suppository
+ hydrocodone - Norco/vicodin/lortab
+ oxycodone - endocet/percocet
+ codeine - tylenol #2/3/4
+ tramadol - Ultracet
+ butabital/caffeine - Fioricet
Maximum daily dose of APAP is correct answers -4000 mg/day frm all
sources
Pediatric APAP dosing correct answers -10-15 mg/kg q4-6 hours
max 5 doses per day
, APAP boxed warning correct answers -Hepatotoxicity associated with
doses >4g per day or use of multiple APAP containing products
APAP SE correct answers -severe skin rash including SJS/TEN
APAP safety correct answers -avoid the APAP abbreviation (lol)
The antidote for APAP overdose is correct answers -N-acetylcysteine
(NAC/Mucomyst/cetylev/acetadote)
NAC function correct answers -restores intracellular glutathione
available in both oral/IV
Rumack-matthew nomogram useds the serum APAP level and time of
ingestion to determine whether hepatotoxicity is likely and if NAC is needed
Non selective NSAIDs block the synthesis of correct answers -COX1/2
enzymes
COX-2 selective NSAIDs have lower GI risk because correct answers -COX-
1 protects the gastric mucosa
Aspirin irreversibly binds to correct answers -COX-1 which decreases the
formation of thromboxane A2, a component in platelet activation
All NSAIDs requires a ____ due to the risks associated with use correct
answers -MedGuide
NSAID GI risk correct answers -increased risk of bleeding and ulcerations
NSAIDs CV risk correct answers -increased risk of MI and stroke
NSAID use is CI in CABG surgery
-antiplatelet therapy such as aspirin is recommended insteqad
NSAIDs SE correct answers -Decrease renal blood flow to glomerulus,
caution in renal failure
Increased BP,avoid in uncontrolled HTN
Premature closure of the ductus arteriosus which can cause heart failure in
babies. Avoid using in 3rd trimester of pregnancy >30 weeks
