BOC Immunology Exam Questions with 100%
Correct Answers | Verified
Which of the following is the most sensitive and appropriate method for the detection
of rheumatoid factor?
a) nephelometry
b) immunofixation electrophoresis
c) immunofluorescence
d) manual latex agglutination - ✔✔a) nephelometry
Rheumatoid factor reacts with: - ✔✔gamma globulin-coated particles
A consistently and repeatedly negative IFA-ANA is: - ✔✔strong evidence against
untreated SLE
Positive rheumatoid is generally associated with: - ✔✔hyperglobulinemia
rheumatoid factors are immunoglobulins with specificity for allotypic determinants
located on the: - ✔✔Fc fragment of IgG
Rheumatoid factor in a patient's serum may cause a false: - ✔✔positive test for the
detection of IgM class antibodies
Rheumatoid factors are defined as: - ✔✔autoantibodies with specificity for the Fc
portion f the immunoglobulin (IgG) molecule
,High titers of antimicrosomal antibodies are MOST often found in: - ✔✔thyroid
disease
In chronic active hepatitis, high titers of which of the following antibodies are seen?
a) antimitochondrial
b) anti-smooth muscle
c) anti-DNA
d) anti-parietal cell - ✔✔b) anti-smooth muscle
Anti-RNA antibodies are often present in individuals having an anti-nuclear antibody
immunofluorescent pattern that is: - ✔✔nucleolar
Anti-extractable nuclear antigens are MOST likely associated with which of the following
anti-nuclear antibody immunofluorescent patterns?
a) speckled
b) rim
c) diffuse
d) nucleolar - ✔✔a) speckled
In an anti-nuclear antibody indirect immunofluorescence test, a sample of a patient
serum sows a positive, speckled pattern. Which would be the MOST appropriate
additional test to perform?
a) antimitochondrial antibody
, b) immunoglobulin quantitation
c) screen for Sm and RNP antibodies
d) anti-DNA antibody using C lucilae - ✔✔c) screen for Sm and RNP antibodies
In the indirect immunofluorescence method of antibody detection in patient serum, he
labeled antibody is: - ✔✔goat anti-human immunoglobulin
Which of the following describes an antigen-antibody reaction?
a) the reaction is reversible
b) the reaction is the same as a chemical reaction
c) a lattice is formed at prozone
d) a lattice is formed at postzone - ✔✔a) the reaction is reversible
The MOST common label in direct fluorescent antibody technique (DFA) is: -
✔✔fluorescein isothiocyanate
A substrate is first exposed to a patient's serum, then after washing, anti-human
immunoglobulin labeled with a fluorochrome is added. The procedure described is: -
✔✔indirect fluorescence
Avidity may be defined as the: - ✔✔strength of a reacting antibody
In the interpretation of agglutination tests for febrile diseases, which of the following is
of he greatest diagnostic importance?
a) anamnestic reactions caused by heterologous antigens
Correct Answers | Verified
Which of the following is the most sensitive and appropriate method for the detection
of rheumatoid factor?
a) nephelometry
b) immunofixation electrophoresis
c) immunofluorescence
d) manual latex agglutination - ✔✔a) nephelometry
Rheumatoid factor reacts with: - ✔✔gamma globulin-coated particles
A consistently and repeatedly negative IFA-ANA is: - ✔✔strong evidence against
untreated SLE
Positive rheumatoid is generally associated with: - ✔✔hyperglobulinemia
rheumatoid factors are immunoglobulins with specificity for allotypic determinants
located on the: - ✔✔Fc fragment of IgG
Rheumatoid factor in a patient's serum may cause a false: - ✔✔positive test for the
detection of IgM class antibodies
Rheumatoid factors are defined as: - ✔✔autoantibodies with specificity for the Fc
portion f the immunoglobulin (IgG) molecule
,High titers of antimicrosomal antibodies are MOST often found in: - ✔✔thyroid
disease
In chronic active hepatitis, high titers of which of the following antibodies are seen?
a) antimitochondrial
b) anti-smooth muscle
c) anti-DNA
d) anti-parietal cell - ✔✔b) anti-smooth muscle
Anti-RNA antibodies are often present in individuals having an anti-nuclear antibody
immunofluorescent pattern that is: - ✔✔nucleolar
Anti-extractable nuclear antigens are MOST likely associated with which of the following
anti-nuclear antibody immunofluorescent patterns?
a) speckled
b) rim
c) diffuse
d) nucleolar - ✔✔a) speckled
In an anti-nuclear antibody indirect immunofluorescence test, a sample of a patient
serum sows a positive, speckled pattern. Which would be the MOST appropriate
additional test to perform?
a) antimitochondrial antibody
, b) immunoglobulin quantitation
c) screen for Sm and RNP antibodies
d) anti-DNA antibody using C lucilae - ✔✔c) screen for Sm and RNP antibodies
In the indirect immunofluorescence method of antibody detection in patient serum, he
labeled antibody is: - ✔✔goat anti-human immunoglobulin
Which of the following describes an antigen-antibody reaction?
a) the reaction is reversible
b) the reaction is the same as a chemical reaction
c) a lattice is formed at prozone
d) a lattice is formed at postzone - ✔✔a) the reaction is reversible
The MOST common label in direct fluorescent antibody technique (DFA) is: -
✔✔fluorescein isothiocyanate
A substrate is first exposed to a patient's serum, then after washing, anti-human
immunoglobulin labeled with a fluorochrome is added. The procedure described is: -
✔✔indirect fluorescence
Avidity may be defined as the: - ✔✔strength of a reacting antibody
In the interpretation of agglutination tests for febrile diseases, which of the following is
of he greatest diagnostic importance?
a) anamnestic reactions caused by heterologous antigens
