Which Public Health Service (PHS) organization is responsible for monitoring
organizational compliance with PHS Policy? correct answer -Office of
Laboratory Animal Welfare (OLAW)
Which of these statements is true? correct answer -The USDA developed
the Animal Welfare Regulations (AWR) to enforce the Animal Welfare Act
(AWA).
Which of the following is true of AAALAC International? correct answer -
Sponsors a voluntary accreditation program for animal care and use
programs.
Which of the following Guides is best used as a source of guidance for animals
used in agricultural research and teaching? correct answer -The Guide for
the Care and Use of Agricultural Animals in Research and Teaching (the Ag
Guide)
The Animal Welfare Regulations (AWR) do not currently apply to which of the
following animals? correct answer -Non-vertebrates, laboratory mice, and
laboratory rats.
What are the two principal animal research regulatory documents used by the
Office of Laboratory Animal Welfare (OLAW)? correct answer -The PHS
Policy on Humane Care and Use of Laboratory Animals and the Guide for the
Care and Use of Laboratory Animals (the Guide).
Which of the following organizations must comply with the PHS Policy when
utilizing vertebrate animals for research, teaching, or testing? correct
answer -Those organizations that accept Public Health Service (PHS) or
National Science Foundation (NSF) funding.
What is the primary purpose of the "3 Rs" concept? correct answer -Urge
investigators to minimize use of animals and minimize pain and distress
caused by animal research.
, Which of the following activities would place an animal in category E?
correct answer -Lethal dose experiments in which animals are allowed to die
without intervention.
Which of the following is an example of refinement? correct answer -The
use of newer surgical techniques that result in less tissue trauma.
Including which of the following activities in a project would disqualify an
animal from USDA category C? correct answer -Surgery
Which of the following statements is true regarding cervical dislocation?
correct answer -Cervical dislocation may be performed in immature rats (<
200 g) and rabbits.
Which of the following justifications for using a particular species would not
likely be accepted by the IACUC? correct answer -The particular species is
inexpensive to buy and maintain.
Which of the following activities would disqualify an animal from USDA
category D? correct answer -Studies in which animals experiencing pain
are allowed to die without pain relief.
Which of the following is false concerning prolonged restraint of animals?
correct answer -It can be justified simply as a convenience for the research
staff.
Which of the following statements is true about the use of carbon dioxide for
euthanasia? correct answer -Carbon dioxide is acceptable with conditions
for euthanasia in those species where aversion or distress can be minimized.
Humane endpoint criteria define the conditions under which: correct
answer -Intervention must occur to remove an animal from a study,
sometimes by euthanizing the animal.
Which of the following items is helpful to the IACUC when reviewing an
animal protocol? correct answer -Flowcharts that illustrate complex
experimental designs.