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Chapter 01 - Introduction to Drugs s s s s s
A nurse working in radiology administers iodine to a patient who is having a computed tomography (CT)
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scan. The nurse working on the oncology unit administers chemotherapy to patients who have
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cancer. At the Public Health Department, a nurse administers a measles-mumps-rubella (MMR)
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vaccine to a 14-month-old child as a routine immunization. Which branch of pharmacology best
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describes the actions of all three nurses?
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Pharmacoeconomics
s Pharmacotherapeutic
sPharmacodynamics
s
s Pharmacokinetics
s Ans: B
Feedback:
Pharmacology is the study of the biologic effects of chemicals. Nurses are involved with clinical
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pharmacology or pharmacotherapeutics, which is a branch of pharmacology that deals with the uses of
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drugs to treat, prevent, and diagnose disease. The radiology nurse is administering a drug to help
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diagnose a disease. The oncology nurse is administering a drug to help treat a disease.
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Pharmacoeconomics includes any costs involved in drug therapy. Pharmacodynamics involves how a s s s s s s s s s s s
drug affects the body and pharmacokinetics is how the body acts on the body.
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A physician has ordered intramuscular (IM) injections of morphine, a narcotic, every 4 hours as needed for
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pain in a motor vehicle accident victim. The nurse is aware this drug has a high abuse potential.
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Under what category would morphine be classified?
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Schedule I s
s Schedule II s
s Schedule III s
Schedule IV
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s Ans: B
Feedback:
Narcotics with a high abuse potential are classified as Schedule II drugs because of severe dependence
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liability. Schedule I drugs have high abuse potential and no accepted medical use. Schedule III drugs
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have a lesser abuse potential than II and an accepted medical use. Schedule IV drugs have low abuse
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potential and limited dependence liability.
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When involved in phase III drug evaluation studies, what responsibilities would the nurse have?
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Working with animals who are given experimental drugs
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Choosing appropriate patients to be involved in the drug study
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s Monitoring and observing patients closely for adverse effects
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s Conducting research to determine effectiveness of the drug Ans: C
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Feedback:
Phase III studies involve use of a drug in a vast clinical population in which patients are asked to record
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any symptoms they experience while taking the drugs. Nurses may be responsible for helping collect
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sand analyze the information to be shared with the Food and Drug Administration (FDA) but would not
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sconduct research independently because nurses do not prescribe medications. Use of animals in drug
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stesting is done in the preclinical trials. Select patients who are involved in phase II studies to participate
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in studies where the participants have the disease the drug is intended to treat. These patients are
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smonitored closely for drug action and adverse effects. Phase I studies involve healthy human volunteers
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who are usually paid for their participation. Nurses may observe for adverse effects and toxicity.
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What concept is considered when generic drugs are substituted for brand name drugs?
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Bioavailability
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Critical concentration s
Distribution
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Half-life
s Ans: A
Feedback:
Bioavailability is the portion of a dose of a drug that reaches the systemic circulation and is available to
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act on body cells. Binders used in a generic drug may not be the same as those used in the brand name
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drug. Therefore, the way the body breaks down and uses the drug may differ, which may eliminate a
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generic drug substitution. Critical concentration is the amount of a drug that is needed to cause a
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therapeutic effect and should not differ between generic and brand name medications. Distribution is
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the phase of pharmacokinetics, which involves the movement of a drug to the body’s tissues and is the
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same in generic and brand name drugs. A drug’s half-life is the time it takes for the amount of drug to
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decrease to half the peak level, which should not change when substituting a generic medication.
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A nurse is assessing the patient’s home medication use. After listening to the patient list current
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medications, the nurse asks what priority question?
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Do you take any generic medications?
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Are any of these medications orphan drugs?
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Are these medications safe to take during pregnancy?
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Do you take any over-the-counter medications?
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Ans: D
Feedback:
It is important for the nurse to specifically question use of over-the-counter medications because
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patients may not consider them important. The patient is unlikely to know the meaning of orphan drugs
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unless they too are health care providers. Safety during pregnancy, use of a generic medication, or
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classification of orphan drugs are things the patient would be unable to answer but could be found in
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reference books if the nurse wishes to research them.
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After completing a course on pharmacology for nurses, what will the nurse know?
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Everything necessary for safe and effective medication administration
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Current pharmacologic therapy; the nurse will not require ongoing education for 5 years.
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s General drug information; the nurse can consult a drug guide for specific drug
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s information.The drug actions that are associated with each classification of medication
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Ans:
s C
Feedback:
After completing a pharmacology course nurses will have general drug information needed for safe and
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effective medication administration but will need to consult a drug guide for specific drug information
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before administering any medication. Pharmacology is constantly changing, with new drugs entering
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the market and new uses for existing drugs identified. Continuing education in pharmacology is
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essential to safe practice. Nurses tend to become familiar with the medications they administer most
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often, but there will always be a need to research new drugs and also those the nurse is not familiar with
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because no nurse knows all medications.
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