USMLE Step 1 Rapid Review
Abdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) -
*answers *Budd-Chiari syndrome
Achilles tendon xanthoma - *answers *Familial hypercholesterolemia
Adrenal hemorrhage, hypotension, DIC - *answers *Waterhouse-Friderichsen
syndrome (meningococcemia)
Arachnodactyly, lens dislocation, aortic dissection, hyperflexible joints - *answers
*Marfan's (fibrillin defect)
Athlete with polycythemia - *answers *Erythropoietin injection
Back pain, fever, night sweats, weight loss - *answers *Pott's (TB to the vertebrae)
Bilateral hilar adenopathy, uveitis - *answers *Sarcoid
Blue sclera - *answers *Osteogenesis imperfecta
Bluish line on gingiva - *answers *Burton's line - lead poisoning
Bone pain, bone enlargement, arthritis, (also increased hat size, fracture, increased alk
phos) - *answers *Paget's
Bounding pulses, diastolic hear murmur, head bobbing - *answers *Aortic regurg
Café-au-lait spots, Lisch nodules - *answers *NF (1 = optic glimoas and pheo, 2 =
acoustic Schwannomas)
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty - *answers
*McCune-Albright syndome (G protein problem)
Calf pseudohypertrophy - *answers *Duchenne's muscular dystrophy
Cherry-red spot on macula - *answers *Tay-Sachs, Niemann-Pick, central retinal artery
occlusion
Chest pain, pericardial effusion/friction rub, persistent fever following MI - *answers
*Dressler's (autoimmune post-MI)
Child uses arms to stand up from squat - *answers *Gower's sign (Duchenne's)
Child with fever develops red rash on face that spreads to body - *answers *Slapped
cheek - B19
Chorea, dementia, caudate degeneration - *answers *Huntington's
, USMLE Step 1 Rapid Review
Chronic exercise intolerance with myalgia, fatigue, painful cramps - *answers
*McArdle's (muscle phosphorylase deficiency)
Cold intolerance - *answers *Hypothyroidism
Conjugate lateral gaze palsy, horizontal diplopia - *answers *Internuclear
ophthalmoplegia (MS or stroke)
Continuous machinery heart murmur - *answers *PDA
Cutaneous/dermal edema due to CT expansion - *answers *Myxedema
Dark purple skin / mouth nodules - *answers *Kaposi's sarcoma
Deep, labored breathing / hyperventilation - *answers *Kussmaul breathing, DKA
Dermatitis, dementia, diarrhea - *answers *Pellagra (B3 / niacin deficiency)
Dilated cardiomyopathy, edema, polyneuropathy - *answers *Wet beriberi (B1 /
thiamine deficiency)
Dog or cat bite resulting in infection - *answers *Pasteurella multocida (local cellulitis)
Dry eyes, dry mouth, arthritis - *answers *Sjogren's syndrome
Dysphagia (esophageal webs), glossitis (smooth tongue), iron deficiency anemia -
*answers *Plummer-Vinson syndrome
Elastic skin, hypermobility of joints - *answers *Ehler-Danlos (type III collagen)
Enlarged. hard left supraclavicular node - *answers *VIrchow's node (abdominal met)
Erythroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells - *answers
*Sezary syndrome (cutaneous T cell lymphoma)
Facial muscle spasm upon tapping - *answers *Chvostek's sign (hypocalcemia)
Fat, female, fertile, forty - *answers *Gallstones
Fever, chills, headache, myalgia following antibiotic treatment for syphillis - *answers
*Jarisch-Herxheimer reaction (lysis of spirochetes results in toxin release)
Fever, cough, conjunctivitis, coryza, diffuse rash, Koplick spots - *answers *Measles
Fever, night sweats, weight loss - *answers *B symptoms or TB
Abdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) -
*answers *Budd-Chiari syndrome
Achilles tendon xanthoma - *answers *Familial hypercholesterolemia
Adrenal hemorrhage, hypotension, DIC - *answers *Waterhouse-Friderichsen
syndrome (meningococcemia)
Arachnodactyly, lens dislocation, aortic dissection, hyperflexible joints - *answers
*Marfan's (fibrillin defect)
Athlete with polycythemia - *answers *Erythropoietin injection
Back pain, fever, night sweats, weight loss - *answers *Pott's (TB to the vertebrae)
Bilateral hilar adenopathy, uveitis - *answers *Sarcoid
Blue sclera - *answers *Osteogenesis imperfecta
Bluish line on gingiva - *answers *Burton's line - lead poisoning
Bone pain, bone enlargement, arthritis, (also increased hat size, fracture, increased alk
phos) - *answers *Paget's
Bounding pulses, diastolic hear murmur, head bobbing - *answers *Aortic regurg
Café-au-lait spots, Lisch nodules - *answers *NF (1 = optic glimoas and pheo, 2 =
acoustic Schwannomas)
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty - *answers
*McCune-Albright syndome (G protein problem)
Calf pseudohypertrophy - *answers *Duchenne's muscular dystrophy
Cherry-red spot on macula - *answers *Tay-Sachs, Niemann-Pick, central retinal artery
occlusion
Chest pain, pericardial effusion/friction rub, persistent fever following MI - *answers
*Dressler's (autoimmune post-MI)
Child uses arms to stand up from squat - *answers *Gower's sign (Duchenne's)
Child with fever develops red rash on face that spreads to body - *answers *Slapped
cheek - B19
Chorea, dementia, caudate degeneration - *answers *Huntington's
, USMLE Step 1 Rapid Review
Chronic exercise intolerance with myalgia, fatigue, painful cramps - *answers
*McArdle's (muscle phosphorylase deficiency)
Cold intolerance - *answers *Hypothyroidism
Conjugate lateral gaze palsy, horizontal diplopia - *answers *Internuclear
ophthalmoplegia (MS or stroke)
Continuous machinery heart murmur - *answers *PDA
Cutaneous/dermal edema due to CT expansion - *answers *Myxedema
Dark purple skin / mouth nodules - *answers *Kaposi's sarcoma
Deep, labored breathing / hyperventilation - *answers *Kussmaul breathing, DKA
Dermatitis, dementia, diarrhea - *answers *Pellagra (B3 / niacin deficiency)
Dilated cardiomyopathy, edema, polyneuropathy - *answers *Wet beriberi (B1 /
thiamine deficiency)
Dog or cat bite resulting in infection - *answers *Pasteurella multocida (local cellulitis)
Dry eyes, dry mouth, arthritis - *answers *Sjogren's syndrome
Dysphagia (esophageal webs), glossitis (smooth tongue), iron deficiency anemia -
*answers *Plummer-Vinson syndrome
Elastic skin, hypermobility of joints - *answers *Ehler-Danlos (type III collagen)
Enlarged. hard left supraclavicular node - *answers *VIrchow's node (abdominal met)
Erythroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells - *answers
*Sezary syndrome (cutaneous T cell lymphoma)
Facial muscle spasm upon tapping - *answers *Chvostek's sign (hypocalcemia)
Fat, female, fertile, forty - *answers *Gallstones
Fever, chills, headache, myalgia following antibiotic treatment for syphillis - *answers
*Jarisch-Herxheimer reaction (lysis of spirochetes results in toxin release)
Fever, cough, conjunctivitis, coryza, diffuse rash, Koplick spots - *answers *Measles
Fever, night sweats, weight loss - *answers *B symptoms or TB
