Test Bank for Basic and Clinical Pharmacology 14th Edition By Bertram G. Katzung Chapter 1-66 Complete Guide A+

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BASIC AND CLINICAL PHARMACOLOGY 14thE
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Basic and Clinical Pharmacology 14th Edition Katzung Trevor Test Bank
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DITION KATZUNG TREVOR Test Bank
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Chaptere1.eIntroduction:eTheeNatureeofeDrugse&eDrugeDevelopmente&eRegulation


1.
Aenurseeworkingeineradiologyeadministerseiodineetoeaepatientewhoeisehavingea
ecomputedetomographye(CT)escan.eTheenurseeworkingeonetheeoncologyeunitead


ministersechemotherapyetoepatientsewhoehaveecancer.eAtetheePubliceHealtheDep
artment,eaenurseeadministerseaemeasles-mumps-rubellae(MMR)evaccineetoeae14-
month-
oldechildeaseaeroutineeimmunization.eWhichebrancheofepharmacologyebestedescr
ibesetheeactionseofeallethreee nurses?
A) Pharmacoeconomics

B) Pharmacotherapeutics

C) Pharmacodynamics

D) Pharmacokinetics

Ans: B

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Pharmacologyeisetheestudyeofetheebiologiceeffectseofechemicals.eNurseseareeinvo
lvedewitheclinicalepharmacologyeorepharmacotherapeutics,ewhicheiseaebrancheof
epharmacologyethatedealsewithetheeuseseofedrugsetoetreat,eprevent,eandediagnosee


disease.eTheeradiologyenurseeiseadministeringeaedrugetoehelpediagnoseeaedisease
.eTheeoncologyenurseeiseadministeringeaedrugetoehelpetreateaedisease.ePharmacoe
conomicseincludeseanyecostseinvolvedeinedruge therapy.
Pharmacodynamicseinvolvesehoweaedrugeaffectsetheebodyeandep
harmacokineticseisehowetheebodyeactseonetheebody.


2.
Aephysicianehaseorderedeintramusculare(IM)einjectionseofemorphine,eaenarco
tic,eeverye4ehourseaseneededeforepaineineaemotorevehicleeaccidentevictim.eTheenu
rseeiseawareethisedrugehaseaehigheabuseepotential.eUnderewhatecategoryewouldem
orphineebeeclassified?
A) ScheduleeI


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B) ScheduleeII




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C) ScheduleeIII

D) ScheduleeIV

Ans: B

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NarcoticsewitheaehigheabuseepotentialeareeclassifiedeaseScheduleeIIedrugsebecau
seeofesevereedependenceeliability.eScheduleeIedrugsehaveehigheabuseepotentiale
andenoeacceptedemedicaleuse.eScheduleeIIIedrugsehaveeaelessereabuseepotentiale
thaneIIeandeaneacceptedemedicaleuse.eScheduleeIVedrugsehaveeloweabuseepotent
ialeandelimitededependencee liability.


3.
WheneinvolvedeinephaseeIIIedrugeevaluationestudies,ewhateresponsibilitie
sewouldetheenurseehave?
A) Workingewitheanimalsewhoeareegiveneexperimentale drugs

B) Choosingeappropriateepatientsetoebeeinvolvedeinetheedruge study

C) Monitoringeandeobservingepatientsecloselyeforeadversee effects

D) Conductingeresearchetoedetermineeeffectivenesseofethee drug

Ans: C

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PhaseeIIIestudieseinvolveeuseeofeaedrugeineaevasteclinicalepopulationeinewhichep
atientseareeaskedetoerecordeanyesymptomsetheyeexperienceewhileetakingetheedr
ugs.eNursesemayebeeresponsibleeforehelpingecollecteandeanalyzeetheeinformati
onetoebeesharedewithetheeFoodeandeDrugeAdministratione(FDA)ebutewouldenote
conducteresearcheindependentlyebecauseenursesedoenoteprescribeemedications
.eUseeofeanimalseinedrugetestingeisedoneeinetheepreclinicaletrials.eSelectepatients
ewhoeareeinvolvedeinephaseeIIestudiesetoeparticipateeinestudiesewhereetheepartic


ipantsehaveetheediseaseetheedrugeiseintendedetoetreat.eTheseepatientseareemonit
oredecloselyeforedrugeactioneandeadverseeeffects.ePhaseeIestudieseinvolveehealt
hyehumanevolunteersewhoeareeusuallyepaideforetheireparticipation.eNursesemay
eobserveeforeadverseeeffectseandetoxicity.




4.
Whateconcepteiseconsideredewhenegenericedrugseareesubstitutedeforebran
denameedrugs?
A) Bioavailability

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B) Criticaleconcentration

C) Distribution

D) Half-life

Ans: A

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Bioavailabilityeisetheeportioneofeaedoseeofeaedrugethatereachesetheesystemicecirc
ulationeandeiseavailableetoeacteonebodyecells.eBinderseusedeineaegenericedrugema
yenotebeetheesameeasethoseeusedeinetheebrandenameedrug.eTherefore,etheewayeth
eebodyebreaksedowneandeusesetheedrugemayediffer,ewhichemayeeliminateeaegen
ericedrugesubstitution.eCriticaleconcentrationeisetheeamounteofeaedrugethateisenee
dedetoecauseeaetherapeuticeeffecteandeshouldenotedifferebetweenegenericeandebr
andenameemedications.eDistributioneisetheephaseeofepharmacokinetics,ewhichei
nvolvesetheemovementeofeaedrugetoetheebodysetissueseandeisetheesameeinegeneri
ceandebrandenameedrugs.eAedrugsehalf-
lifeeisetheetimeeitetakeseforetheeamounteofedrugetoedecreaseetoehalfetheepeakelevel,
ewhicheshouldenotechangeewhenesubstitutingeaegenerice medication.




5.
Aenurseeiseassessingetheepatientsehomeemedicationeuse.eAfterelisteningetoeth
eepatientelistecurrentemedications,etheenurseeasksewhateprioritye question?
A) Doeyouetakeeanyegenerice medications?

B) Areeanyeofetheseemedicationseorphane drugs?

C) Areetheseemedicationsesafeetoetakeeduringe pregnancy?

D) Doeyouetakeeanyeover-the-countere medications?

Ans: D

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Iteiseimportanteforetheenurseetoespecificallyequestioneuseeofeover-the-
counteremedicationsebecauseepatientsemayenoteconsiderethemeimportant.eTheep
atienteiseunlikelyetoeknowetheemeaningeofeorphanedrugseunlessetheyetooeareehea
lthecareeproviders.eSafetyeduringepregnancy,euseeofeaegenericemedication,eorecl
assificationeofeorphanedrugseareethingsetheepatientewouldebeeunableetoeanswere
butecouldebeefoundeinereferenceebookseifetheenurseewishesetoeresearchethem.




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