Cysts of orofacial
region
It is defined as a pathological cavity, may or may not be lin
by epithelium and containing fluid, semisolid or gaseous
The wall or the capsule is composed of the collagenous fib
connective tissue, usually with an epithelial lining and it pro
various bone resorbing factors for its growth and expansio
REFERENCE -SH
PATHOLOGY 9TH
AND BRAD W N
,
,The odontogenic cysts are derived from epithelium assoc
development of the dental apparatus
The lesion is named keratocyst because the lining epithe
so much keratin that almost fills the cyst lumen.
Fu hermore, fla ened epithelium–connective tissue int
palisading of the basal epithelial cells, reminiscent of odo
epithelium, are characteristics of this lesion
In 2005, the World Health Organization (WHO) reclassifie
labeled it keratocystic odontogenic tumor (KCOT) based
aggressive behavior, recurrence, and mutations in the PT
In addition, there were repo s of nondetection of PTCH
sporadic cases (nonsyndromic) and failure to detect SM
in syndromic and sporadic cases of OKC
PTCH1, a tumor suppressor gene
In mammals, three hedgehog (HH) signaling proteins
one of which is SHH,
, Binding of HH to PTCH removes this inhibitory effect on S
function as an oncogene. “Loss of function mutations” of
“gain of function mutations” of SMO result in oncogenesis
OKC is an aggressive odontogenic cyst that is derived from
the dental lamina, with distinctive histologic features comp
following
Corrugated parakeratin layer
• Uniform thickness of the lining epithelium of five to eight
cells thickness
• Palisaded basal cell layer
occur at any age
peak second and third decades of life
predilection to occur in males
mandible is invariably affected more frequently
third molar area, followed by the first and second mo
and then the anterior mandible
In the maxilla, the most common site is the third molar
followed by the cuspid region
more common features are pain, so tissue swelling a
expansion of bone, drainage, and various neurologic
manifestations such as paresthesia of the lip or teeth
The aspirate from this lesion mostly contains a cheesy
suggestive of keratin
region
It is defined as a pathological cavity, may or may not be lin
by epithelium and containing fluid, semisolid or gaseous
The wall or the capsule is composed of the collagenous fib
connective tissue, usually with an epithelial lining and it pro
various bone resorbing factors for its growth and expansio
REFERENCE -SH
PATHOLOGY 9TH
AND BRAD W N
,
,The odontogenic cysts are derived from epithelium assoc
development of the dental apparatus
The lesion is named keratocyst because the lining epithe
so much keratin that almost fills the cyst lumen.
Fu hermore, fla ened epithelium–connective tissue int
palisading of the basal epithelial cells, reminiscent of odo
epithelium, are characteristics of this lesion
In 2005, the World Health Organization (WHO) reclassifie
labeled it keratocystic odontogenic tumor (KCOT) based
aggressive behavior, recurrence, and mutations in the PT
In addition, there were repo s of nondetection of PTCH
sporadic cases (nonsyndromic) and failure to detect SM
in syndromic and sporadic cases of OKC
PTCH1, a tumor suppressor gene
In mammals, three hedgehog (HH) signaling proteins
one of which is SHH,
, Binding of HH to PTCH removes this inhibitory effect on S
function as an oncogene. “Loss of function mutations” of
“gain of function mutations” of SMO result in oncogenesis
OKC is an aggressive odontogenic cyst that is derived from
the dental lamina, with distinctive histologic features comp
following
Corrugated parakeratin layer
• Uniform thickness of the lining epithelium of five to eight
cells thickness
• Palisaded basal cell layer
occur at any age
peak second and third decades of life
predilection to occur in males
mandible is invariably affected more frequently
third molar area, followed by the first and second mo
and then the anterior mandible
In the maxilla, the most common site is the third molar
followed by the cuspid region
more common features are pain, so tissue swelling a
expansion of bone, drainage, and various neurologic
manifestations such as paresthesia of the lip or teeth
The aspirate from this lesion mostly contains a cheesy
suggestive of keratin
