n n
MODERN BLOOD B n n
ANKING & TRANSFU n n
SION PRACTICES 6T
n n
H EDITION DENISE
n n n
M.HARMENING
n
,TEST BANK FOR
n n
MODERN BLOOD BANKING
n n n
& TRANSFUSION PRACTICES
n n
6TH EDITION
n
DENISE M. HARMENING
n n
, Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
n n n n n n n n n n
MultiplenChoice
Identifynthenchoicenthatnbestncompletesnthenstatementnornanswersnthenquestion.
n 1.n Whichnmetabolicnpathwaynisnresponsiblenforngeneratingn90%nofnthenATPnfornthenRBC?
a. Pentosenphosphatenshunt c. Glycolysis
b. Luebering-Rapoportnshunt d.n Methemoglobinnreductase
n
2.n Anunitnofnbloodnwasnreturnedntonthenbloodnbanknbeforenitnwasnspiked.nApparentlynthenpatient’snIVnfailed.n
Thenunitnofnbloodnwasnoutsidenthenbloodnbanknforn35nminutes.nWhichnofnthenstatementsnbelownisnmostnaccurat
e?
a. Thenunitnofnbloodnshouldnbendiscardednimmediately.
b. Thenunitnofnbloodncannbenreturnedntoninventory.
c. Thenunitnofnbloodnmustnbentransfusednwithinn4nhoursnornbendiscardednatnthenendnofnthatntime.
d. Thenunitnofnbloodnmustnbentransfusednwithn24nhours.
n 3.n Whatnisnthenaveragendiameternofnanplatelet?
a. 5nton10nµm c. 1nton2nµm
b. 2nton4nµm d.nnn 4nton6nµm
n 4.nInnthennormalnhemoglobin-
oxygenndissociationncurve,nwhatnpercentagenofnoxygennisnreleasedntonthentissuesnwhennPO2naveragesn40nm
mnHg?
a. 75% c. 100%
b.nnn 25% d.n 50%
n 5.n Whatnfactorsnarenknownntoninfluencenplateletnmetabolismnandnfunction?
a. Storagentemperature c. Plateletncount
b. InitialnpH d.n Allnofnthenabove
n
6.nWhichnofnthenfollowingnrednbloodncellnmorphologiesnmaynbenpresentnonnthenperipheralnbloodnsmearnasnanr
esultnofnlossnofnRBCnmembrane?
a. Spherocytes c. Burrncells
b. Targetncells d.n Schistocytes
n 7.n Whatndoesnthentermnautologousntransfusionnrefernto?
a. Anparentndonatingnbloodnfornhisnornhernchild
b. Annindividualndonatingnbloodnfornanfriend
c. Annindividualndonatingnbloodnfornanrelative
d. Annindividualndonatingnbloodnfornhisnornhernownntransfusion
n 8.n Whatnisnthenprimarynfunctionnofnhemoglobin?
a. Ironnmetabolism c. Oxygenntransport
b. Porphyrinnsynthesis d.n Signalntransduction
n 9.n Allnofnthenfollowingnareasnofnrednbloodncellnbiologynarencrucialnfornnormalnerythrocytensurvivaln except:
a. Cellularnmetabolism. c. SitenofnthenABOnantigennattachment.
b. RBCnmembrane. d.n Hemoglobinnstructure.
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, n nn 10.n WhatnisnthencorrectnbiochemicalncompositionnofnthenRBCnmembrane?
a. 52%nprotein,n40%nlipid,n8%ncarbohydrate
b. 40%nprotein,n8%nlipid,n52%ncarbohydrate
c. 8%nprotein,n52%nlipid,n40%ncarbohydrate
d. 8%nlipid,n40%ncarbohydrate,n52%nprotein
n nnn 11.n Allnofnthenfollowingnbiochemicalnchangesnarenassociatednwithnlossnofnrednbloodncellnviabilitynuponnstorage
except:
a. DecreasednpH. c. IncreasednATPnlevel.
b. Lossnofnrednbloodncellnfunction. d.n Decreasednglucosenconsumption.
n nn 12.n Whichnrednbloodncellnpreservativenhasnanstoragentimenofn35ndays?
a. ACD c. AS-1
b. CPDA-1 d.nnn CPD
n nn 13.n ThenRBCnmembranenisnrelativelynpermeablentonallnofnthenfollowingn except:
a. Chloride. c. Bicarbonate.
b. Sodium. d.n Water.
n
nn 14.nWhatnpercentagenofnplateletsnisnsequesteredninnthenspleennasnfunctionalnreservenafternbeingnreleasednfr
omnthenbonenmarrow?
a. 30% c. 10%
b.nnn 50% d.nnn 25%
n nn 15.n Whatnisnthenmajornbiochemicalnconsiderationninnplateletnstorage?
a. Glucosenmetabolism c. Productionnofncarbonndioxide
b. Oxygennsupply d.n RegulationnofnpH
n nn 16.nWhatnwouldnthenhemoglobin-
oxygenndissociationncurvendepictninnanpatientnexhibitingnclinicalnsignsnofnalkalosis?
a. Normal c. Shiftntonthenright
b. Shiftntonthenleft d.n Nonenofnthenabove
n nn 17.n Namenthenmainnlipidncomponentsnofnanrednbloodncellnmembrane.
a. Phospholipid c. Glycolipid
b. Sphingomyelin d.n GlycophorinnA
n nn 18.n ThenABOnbloodngroupsnwerendiscoveredninn1901nbynwhom?
a. CharlesnDrew c. LoutitnandnMollison
b. KarlnLandsteiner d.n EdwardnLindeman
n
19.nAnstandingnordernofnplateletsnwasnshippedntonyournfacilitynbynyournsupplier.nItnwasninadvertentlynleftni
nn
nnthencornernofnthendepartmentnuntilndiscoveredn36nhoursnlater.nWhatnwouldnthenappropriatenactionnbenfornthenb
loodnbanker?
a. Ifnthentemperatureninnthenboxnwasn22n+/-
n2°CnandnthenplateletnswirlnseemednOK,nitnwouldnbenOKntonacceptnthenunitnintoninventory.
b. Thenplateletsnhavenfallennoutsidenthensupplier’snqualitynassurance.nThenunitnshouldnbe
discardednbecausenthenpHnhasnprobablyndroppedntoonlownandnplateletnactivationnhasnbeenncompromised.
c. Ifnthentemperaturenwasn1°Cnton6°CnandnthenplateletnswirlnseemednOK,nitnwouldnbenOKnto
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