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Ferrous Sulfate for anemia
Iron supplement for anemia - Increases serum iron concentrations to allow conversion
to Hgb to help make RBCs
LABS BEFORE: Hgb & Hct (establish baseline) and monitor*
DO NOT TAKE WITH FOOD
Side Effects: dark stool (normal), constipation, Nausea, abdominal Pain
Contraindications: thalassemias, alcoholism, do not take with antacids, tetracyclines,
quinolones
Cyanocobalamin (Vitamin B12) side effects
hypokalemia, erythema, HTN, we need this for DNA synthesis
-mild diarrhea
- skin rash
- headache
- dizziness
- nausea
- vomiting
- pulmonary edema and - congestive heart failure early in treatment
- vein thrombosis
- sensation of swelling
- polycythemia Vera (rare, slow growing blood cancer)
- allergic reactions (anaphylaxis). This includes swelling of the face, tongue, and throat,
and difficulty swallowing and breathing.
Folic acid side effects
- supplement helps with erythropoiesis
- intense yellow urine
- increases cancer risk
- all routes
heparin
Factor Xa/Thrombin Inhibitors
blocks clotting process
thrombocytopenia
Contraindication for use:
⎼ Hx of peptic ulcers
Avoid giving IM injections while anticoagulated
Goal aPTT level = 1-3x control
⎼ Antidote = protamine sulfate**
Heparin risk factors
• Bleeding history, especially:
, • More severe bleeding episodes (e.g., any CNS bleeding).
• More recent bleeding.
• Coagulopathy, for example:
• Thrombocytopenia (e.g., <30 billion/L is an absolute contraindication)
• Simultaneous use of multiple anticoagulant/antiplatelet agents.
• Renal failure (uremia causes platelet dysfunction).
• Liver disease.
• Vasculopathy, for example:
• Older age.
• Chronic uncontrolled hypertension.
• CNS disease (e.g., prior intracranial hemorrhage, vascular malformation, active
malignancy)
.• Planned procedures
UFH half life
1 hr
heparin protocol
indications: prophylaxis and tx of thromboembolic disorders like acute coronary
syndrome, DVT, PE
high alert
must have second nurse to witness drip
Alt therapy is argatroban which is a direct thrombin inhibitor that acts by thinning blood.
uses are Coronary artery thrombosis and heparin induced thrombocytopenia
antidote: protamine sulfate combines with strongly acidic heparin to form a stable
complex neutralizing the anticoagulant activity. admin very slowly.
enoxaparin
inject in the abdomen
Enoxaparin is a low molecular weight heparin used for the prophylaxis of deep vein
thrombosis and ischemic complications of unstable angina and non-Q-wave myocardial
infarction.
can cause thrombocytopenia - monitor platelets
look for uncontrolled bleeding
black vomit or red/pink urine, dizziness, bruising
warfarin
Vitamin K Antagonists
used to prevent blood clots from forming or growing larger in your blood and
blood vessels
decrease in production of vitaminK-dependent clotting factors in liver causing
depletion
Concurrent medications to avoid:
⎼ NSAIDs
Goal INR level = 2-3
INR
blood clotting test
high value means blood is too thin
low value means blood will clot too easily
warfarin SE and considerations