WITH COMPLETE SOLUTIONS VERIFIED GRADED A+
What is the major cation and anion in intracellular and extracellular fluids?
More K+ inside the cell
More Na+ outside the cell
Balanced charge
total + and - charge are always equal.
Na+, Cl- and HCO3 always moving in and out to maintain the balance
Anion gap
total charge of cation and anion in plasma (mmol/L)
Na+ Cl- HCO3-
Increased anion gap
Causes of increased unmeasured anions:
-Metabolic acidosis: ketoacidosis, uremia, lactic acidosis, salicylate poisoning.
-Non-metabolic acidosis: hyperphosphatemia, hypersulfatemia, large dose of anionic
medication, protein net charge shifted in alkalosis
Causes of decreased unmeasured cations:
-hypocalcemia
-hypomagnesemia
Decreased anion gap