BLD 402 STUDY GUIDE EXAM QUESTIONS AND ANSWERS
WITH COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
Reasons a patient is not getting better on a prescribed drug?
lack of compliance, increased liver metabolism, bioavailblity and distribution of drug
Describe a graph that would describe the drug level for a multiple dose regime.
multiple little rises and falls that try to keep the drug at a fairly consistent level
Describe a graph for an orally delivered drug.
Small rise to maximum drug level then steady decrease
Describe a graph for IV bolus delivered drug.
Sharp increase to maximum drug level then steady decrease.
What are the facotrs that affect frfee fraction of drug?
available binging sites (competition) and concentration of binding sites
Why to we do therapeutic drug monitoring?
Check the diagnosis, check therapy choice and check dosage of therapy
What are the requirements for drug testing?
increase sensitivity and sensitivity
What lab tests are in a coma panel?
alcohol, ammonia, Ca, creatine, glucose, lactic acid, osmolarity, Phenobarbital, tox
screen for drugs
When does cell injury start in acetaminophen over dose?
when P450 starts producing reactive oxidative molecules
,What is a main enzyme in alcohol metabolism?
aldehyde dehydrogenase
How are toxic substance treated in the body?
foreign substances are processed through xenobiotic metabolism and others are
conjugated then excreted
What is ED50?
effective dose for 50% of the population
What is LD50?
lethal dose for 50% of the population
What is the TD50?
the toxic dose in 50% of the people
______ cancer has an increased CEA level
colorectal adenocarcinoma
What is PSA and what is it used for?
Prostate Screening Antigen-- starts at 55 yo., also monitors benign enlarged prostate,
also used to stage and monitor therapy
What CK is increased in skeletal muscle malignancy?
CK-MM
What CK is increased in ovarian and small cell lung malignancy?
CK-MB
What is the utility of a tumor marker?
diagnosis, monitor therapy, screen for cancer and detection of reoccurrence ect.
***reoccurrence is most key
, What is the reporting rule for drugs of abuse?
must run a confirmation test before confirming
What are the characteristics of a drug test vs. a confirmation test?
increased sensitivity but not specificity for drug test both are increased in a confirmation
test
__________ is the cause of cystic fibrosis
defect in the epthethial transmembrane regulator
What are the symptoms of cystic fibrosis?
mucus buildup in some internal organs and abnormal absorption of nutrients in the
small intestine
male infertility
pancreatic insufficiency
What tests are run for cystic fibrosis?
Sweat test (increased Cl is positive for CF)
Screening test for newborns: serum immunoreactive trypsin
What is the cause of Maple Syrup Urine Disease?
A defect in the pathway that breaks down the branch-chained amino acids: Isoleucine,
Leucine, and Valine
What is the consequences of MSUD?
accumulation of of keto acids due to enzyme def
What is the cause of the Phenylketuria?
deficiency in the phelydianine hydroxylase
What are the consequences of PKU?
WITH COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
Reasons a patient is not getting better on a prescribed drug?
lack of compliance, increased liver metabolism, bioavailblity and distribution of drug
Describe a graph that would describe the drug level for a multiple dose regime.
multiple little rises and falls that try to keep the drug at a fairly consistent level
Describe a graph for an orally delivered drug.
Small rise to maximum drug level then steady decrease
Describe a graph for IV bolus delivered drug.
Sharp increase to maximum drug level then steady decrease.
What are the facotrs that affect frfee fraction of drug?
available binging sites (competition) and concentration of binding sites
Why to we do therapeutic drug monitoring?
Check the diagnosis, check therapy choice and check dosage of therapy
What are the requirements for drug testing?
increase sensitivity and sensitivity
What lab tests are in a coma panel?
alcohol, ammonia, Ca, creatine, glucose, lactic acid, osmolarity, Phenobarbital, tox
screen for drugs
When does cell injury start in acetaminophen over dose?
when P450 starts producing reactive oxidative molecules
,What is a main enzyme in alcohol metabolism?
aldehyde dehydrogenase
How are toxic substance treated in the body?
foreign substances are processed through xenobiotic metabolism and others are
conjugated then excreted
What is ED50?
effective dose for 50% of the population
What is LD50?
lethal dose for 50% of the population
What is the TD50?
the toxic dose in 50% of the people
______ cancer has an increased CEA level
colorectal adenocarcinoma
What is PSA and what is it used for?
Prostate Screening Antigen-- starts at 55 yo., also monitors benign enlarged prostate,
also used to stage and monitor therapy
What CK is increased in skeletal muscle malignancy?
CK-MM
What CK is increased in ovarian and small cell lung malignancy?
CK-MB
What is the utility of a tumor marker?
diagnosis, monitor therapy, screen for cancer and detection of reoccurrence ect.
***reoccurrence is most key
, What is the reporting rule for drugs of abuse?
must run a confirmation test before confirming
What are the characteristics of a drug test vs. a confirmation test?
increased sensitivity but not specificity for drug test both are increased in a confirmation
test
__________ is the cause of cystic fibrosis
defect in the epthethial transmembrane regulator
What are the symptoms of cystic fibrosis?
mucus buildup in some internal organs and abnormal absorption of nutrients in the
small intestine
male infertility
pancreatic insufficiency
What tests are run for cystic fibrosis?
Sweat test (increased Cl is positive for CF)
Screening test for newborns: serum immunoreactive trypsin
What is the cause of Maple Syrup Urine Disease?
A defect in the pathway that breaks down the branch-chained amino acids: Isoleucine,
Leucine, and Valine
What is the consequences of MSUD?
accumulation of of keto acids due to enzyme def
What is the cause of the Phenylketuria?
deficiency in the phelydianine hydroxylase
What are the consequences of PKU?
