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GnRH
- secreted from hypothalamus
- Function: Stimulates anterior pituitary for gonadotropins (FSH, LH) secretion
Gonadotropins
FSH and LH
- Secreted from pituitary
Function:
- LH- stimulate corpus lute and ovary in female
- FSH- follicular development in female
Estrogens
Secreted from:
- Estradiol (E2)
- Estriol (E3)
Function:
- E2:
- Development of secondary sex characteristics
- Maintains corpus luteum
, - Induce mitosis of endometrial (thickening endometrial)
- E3: maintain pregnancy
Progesterone
Secreted from ovary (corpus luteum) and placenta
Function:
- Stimulate differentiation of endometrium
- Implantation of fertilized ovum
- Maintain corpus lute and early stage of pregnancy
Prolactin-releasing hormone
Secreted from hypothalamus
Prolactin
Secreted from anterior pituitary
Function:
- Mammary gland development
- production at ovary
Hormone flow
Hypothalamus-(GnRH)- pituitary-(LH, FSH)- Ovary-(progesterone, E2)- target
Menstrual cycle
- at end of last cycle, last corpus lute is degrading- progesterone decreases and E2
decreases= menses
- LH reached to peak- ovulation after half day
- E2 and progesterone are secreted from corpus luteum
- progesterone inhibit LH and FSH secretion