BLD 204 FINAL EXAM QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
First thing a tumor needs to do to migrate to a new site:
Shed/release cells from main tumor
Behavior of normal cells do cancer cells ignore which they have APC mutations:
Contact inhibition
If a microRNA gene in a cancer cell is mutated so that it no longer binds its
target:
Increased expression of oncogenes
If a signal transducing protein like RAS has a gain of function mutation, will
treating therapeutic targets upstream in the signaling pathway help the patient:
No
Genes for proteins like p53 which monitor cells for problems belong to which
class of proteins:
Tumor suppressor genes
Although cancer begins in a monoclonal cell line, by the time it is diagnosed and
treated the tumor is usually heterogenous with multiple successful sub clonal
populations, why:
Genome instability and natural selection
Benign is most often used to describe:
A tumor that is contained and slow growing
,Cancer test that can give the most information about treatment and prognosis:
Whole tumor profiling
Most quickly cause mechanical pressure for a cancer patient if a tumor developed
there:
Marrow cavity of the bone
Cause Problematic hemorrhage:
Colon cancer
Not a confirmed risk factor for developing cancer:
Childhood vaccinations
While dysplasia is a warning signal that cells are dysregulated for some
reason, ______________ describes cells that are very abnormal in size,
morphology, and orientation and is a sign that cancer has developed.
anaplasia
Normal differentiation and doesn't have all the hallmarks, abnormal growth but
not cancer:
Choristoma
Second most common chromosome change that can lead to cancer is
Deletion
Mutations related to genome instability:
BRCA1 and BRCA2 loss of function
Limitless replicative potential develops In part due to loss of function of:
P53
Someone has B2 and B53 alleles for HLA-A, learned about the
, genotype
Mistakes during meiosis I or meiosis II can result in chromosomes or sister
chromatids ending up in the same gamete.
Nondisjunction
Translocation
Klinefelter syndrome
XXY
Incidence of down syndrome is much higher in patients whose mothers are
Over age 35
Philadelphia chromosome
CML
Insertion of 1-2 nucleotides in gene creates
Frameshift mutation
A point mutation that results in a new amino acid in the final protein is
Missense mutation
Duplications in genes occur because what enzyme doesn't do its job accurately
Polymerase
Inheritance pattern familial hypercholesterolemia
autosomal dominant
Protein that doesn't function in familial hypercholesterolemia
LDL receptor
PKU (phenylketonuria)
autosomal recessive
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
First thing a tumor needs to do to migrate to a new site:
Shed/release cells from main tumor
Behavior of normal cells do cancer cells ignore which they have APC mutations:
Contact inhibition
If a microRNA gene in a cancer cell is mutated so that it no longer binds its
target:
Increased expression of oncogenes
If a signal transducing protein like RAS has a gain of function mutation, will
treating therapeutic targets upstream in the signaling pathway help the patient:
No
Genes for proteins like p53 which monitor cells for problems belong to which
class of proteins:
Tumor suppressor genes
Although cancer begins in a monoclonal cell line, by the time it is diagnosed and
treated the tumor is usually heterogenous with multiple successful sub clonal
populations, why:
Genome instability and natural selection
Benign is most often used to describe:
A tumor that is contained and slow growing
,Cancer test that can give the most information about treatment and prognosis:
Whole tumor profiling
Most quickly cause mechanical pressure for a cancer patient if a tumor developed
there:
Marrow cavity of the bone
Cause Problematic hemorrhage:
Colon cancer
Not a confirmed risk factor for developing cancer:
Childhood vaccinations
While dysplasia is a warning signal that cells are dysregulated for some
reason, ______________ describes cells that are very abnormal in size,
morphology, and orientation and is a sign that cancer has developed.
anaplasia
Normal differentiation and doesn't have all the hallmarks, abnormal growth but
not cancer:
Choristoma
Second most common chromosome change that can lead to cancer is
Deletion
Mutations related to genome instability:
BRCA1 and BRCA2 loss of function
Limitless replicative potential develops In part due to loss of function of:
P53
Someone has B2 and B53 alleles for HLA-A, learned about the
, genotype
Mistakes during meiosis I or meiosis II can result in chromosomes or sister
chromatids ending up in the same gamete.
Nondisjunction
Translocation
Klinefelter syndrome
XXY
Incidence of down syndrome is much higher in patients whose mothers are
Over age 35
Philadelphia chromosome
CML
Insertion of 1-2 nucleotides in gene creates
Frameshift mutation
A point mutation that results in a new amino acid in the final protein is
Missense mutation
Duplications in genes occur because what enzyme doesn't do its job accurately
Polymerase
Inheritance pattern familial hypercholesterolemia
autosomal dominant
Protein that doesn't function in familial hypercholesterolemia
LDL receptor
PKU (phenylketonuria)
autosomal recessive
