BLD 324 FINAL EXAM QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
What coagulation plasma protein should be assayed when platelets fail to
aggregate properly?
Fibrinogen
What serine protease forms a complex with factor VIIIa, and what is the substrate
of this complex?
Factor IXa, factor X
What protein secreted by endothelial cells activates fibrinolysis?
TPA
What two regulatory proteins form a complex that digests activated factors V and
VIII?
APC and protein S
What are the primary roles of VWF?
Mediate platelet adhesion and serve as a carrier molecule for factor VIII
Most coagulation factors are synthesized in:
The liver
The events involved in secondary hemostasis:
Lead to the formation of a stable fibrin clot
Which of the following coagulation factors is activated by thrombin and mediates
the stabilization of the fibrin clot?
, Factor XIII
The WBC is 17,000. There are 10 NRBCs. What is the correct count?
15,454
Von Willebrand Factor binds platelets to collagen via which receptor?
GPlb
Where is the clotting defect?
PT= normal
APTT= prolonged
Platelet Count= normal
PFA-100= normal
Factors only in the contact pathway
Which in vivo clotting event cannot be assessed with coagulation screening
tests?
Activation of Factor IX by VIIa
What is the surface-connected canalicular system of platelets?
A system of channels that opens to the exterior upon platelet activation
What is the source of phospholipid (PPL) in the coagulation cascade?
Platelet membranes
What is the advantage of the Tissue Factor Pathway compared to the Contact
Pathway?
Faster activation
Factor XIII stabilizes the clot by crosslinking-
The D domain to another Fibrin molecule D domain
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
What coagulation plasma protein should be assayed when platelets fail to
aggregate properly?
Fibrinogen
What serine protease forms a complex with factor VIIIa, and what is the substrate
of this complex?
Factor IXa, factor X
What protein secreted by endothelial cells activates fibrinolysis?
TPA
What two regulatory proteins form a complex that digests activated factors V and
VIII?
APC and protein S
What are the primary roles of VWF?
Mediate platelet adhesion and serve as a carrier molecule for factor VIII
Most coagulation factors are synthesized in:
The liver
The events involved in secondary hemostasis:
Lead to the formation of a stable fibrin clot
Which of the following coagulation factors is activated by thrombin and mediates
the stabilization of the fibrin clot?
, Factor XIII
The WBC is 17,000. There are 10 NRBCs. What is the correct count?
15,454
Von Willebrand Factor binds platelets to collagen via which receptor?
GPlb
Where is the clotting defect?
PT= normal
APTT= prolonged
Platelet Count= normal
PFA-100= normal
Factors only in the contact pathway
Which in vivo clotting event cannot be assessed with coagulation screening
tests?
Activation of Factor IX by VIIa
What is the surface-connected canalicular system of platelets?
A system of channels that opens to the exterior upon platelet activation
What is the source of phospholipid (PPL) in the coagulation cascade?
Platelet membranes
What is the advantage of the Tissue Factor Pathway compared to the Contact
Pathway?
Faster activation
Factor XIII stabilizes the clot by crosslinking-
The D domain to another Fibrin molecule D domain
