BLD 324 EXAM QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
For cell identification of RBC precursors using a Wright Stained smear, what
structure is unique to the pronormoblast?
Nucleolus
What cytokine decreases the time it takes to produce a mature RBC
EPO
What is considered a RBC progenitor
BFU-E
Asymmetric mitosis occurs in which RBC precursor stage
Orthochromic normoblast (metarubicyte)
The role of hepcidin is to
Regulate the transfer of iron into the blood by enterocytes
Iron enters developing red blood cells via
Transferrin and the transferrin receptor
Fe3+ (ferric) iron is present in what circumstances
During transport to cells like developing red blood cells
When a cells iron levels drop how will it respond
produce less ferritin
What characteristic of stem cells is essential to the production of RBCs
throughout a persons lifetime?
,They can produce more stem cells after division
What cell is not derived from the common myeloid progenitor
B lymphocytes
The last stage in RBC development that can divide using mitosis to generate two
identical cells is
Polychromatic normoblast (rubricyte)
What morphologic change occurs over the course of normoblast maturation
Coarsening of nuclear chromatin
What cytokine is important in production of platelets from the megakaryoblast
Thrombopoietin (TPO)
What cytokine is required for differentiation of the hematopoietic stem cell (HSC)
FLT 3
What normoblast stage does globin chain production start
Pronormoblast (Rubriblast)
The hemoglobin molecule is composed of
Four heme molecules and four globes chains
The rate limiting step in heme synthesis is control of what enzyme
Aminolevulinate (ALA) synthase
Which form of hemoglobin has the lowest affinity for oxygen
Tense
The total iron binding capacity of the serum is an indirect measure of what
molecule
Transferrin
, What is the first step for iron absorption to transport to incorporation into heme
DMT1 transports ferrous iron into the enterocyte
what happens after DMT1 transports ferrous iron into the enterocyte
Ferroportin transports iron from enterocyte to plasma
what happens after Ferroportin transports iron from enterocyte to plasma
Transferrin picks up ferric iron
what happens after Transferrin picks up ferric iron
The transferrin receptor transports iron into the cell
What happens after The transferrin receptor transports iron into the cell
Iron is transferred to the mitochondria
The process of formation and development of blood cells is termed
Hematopoiesis
During the second trimester of fetal development, the primary site of blood cell
production is the
Liver
The best source of active bone marrow from a 20 year old would be
Lliac crest
Physiologic programmed cell death is termed
Apoptosis
What morphologic change occurs during normal blood cell maturation
Condensation of nuclear chromatin
What growth factor is produced in the kidneys and is used to treat anemia
associated with kidney disease
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
For cell identification of RBC precursors using a Wright Stained smear, what
structure is unique to the pronormoblast?
Nucleolus
What cytokine decreases the time it takes to produce a mature RBC
EPO
What is considered a RBC progenitor
BFU-E
Asymmetric mitosis occurs in which RBC precursor stage
Orthochromic normoblast (metarubicyte)
The role of hepcidin is to
Regulate the transfer of iron into the blood by enterocytes
Iron enters developing red blood cells via
Transferrin and the transferrin receptor
Fe3+ (ferric) iron is present in what circumstances
During transport to cells like developing red blood cells
When a cells iron levels drop how will it respond
produce less ferritin
What characteristic of stem cells is essential to the production of RBCs
throughout a persons lifetime?
,They can produce more stem cells after division
What cell is not derived from the common myeloid progenitor
B lymphocytes
The last stage in RBC development that can divide using mitosis to generate two
identical cells is
Polychromatic normoblast (rubricyte)
What morphologic change occurs over the course of normoblast maturation
Coarsening of nuclear chromatin
What cytokine is important in production of platelets from the megakaryoblast
Thrombopoietin (TPO)
What cytokine is required for differentiation of the hematopoietic stem cell (HSC)
FLT 3
What normoblast stage does globin chain production start
Pronormoblast (Rubriblast)
The hemoglobin molecule is composed of
Four heme molecules and four globes chains
The rate limiting step in heme synthesis is control of what enzyme
Aminolevulinate (ALA) synthase
Which form of hemoglobin has the lowest affinity for oxygen
Tense
The total iron binding capacity of the serum is an indirect measure of what
molecule
Transferrin
, What is the first step for iron absorption to transport to incorporation into heme
DMT1 transports ferrous iron into the enterocyte
what happens after DMT1 transports ferrous iron into the enterocyte
Ferroportin transports iron from enterocyte to plasma
what happens after Ferroportin transports iron from enterocyte to plasma
Transferrin picks up ferric iron
what happens after Transferrin picks up ferric iron
The transferrin receptor transports iron into the cell
What happens after The transferrin receptor transports iron into the cell
Iron is transferred to the mitochondria
The process of formation and development of blood cells is termed
Hematopoiesis
During the second trimester of fetal development, the primary site of blood cell
production is the
Liver
The best source of active bone marrow from a 20 year old would be
Lliac crest
Physiologic programmed cell death is termed
Apoptosis
What morphologic change occurs during normal blood cell maturation
Condensation of nuclear chromatin
What growth factor is produced in the kidneys and is used to treat anemia
associated with kidney disease
