BLD 324 EXAM#2 QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
What is the state of the granule of neutrophils
acid and basic
What is the state of the granule of eosinophils
basic stained with eosin
What is the state of the granule of neutrophils
acidic stained with methylene blue
What is the common progenitor of neutrophil, onocyte, eosinophil, and basophil
common myeloid progenitor
Mononuclear cells include:
monocyte and lymphocyte
What are the two forms of neutrophils
Polymorphonuclear (PMN) and Band
*PMN is major form, Band only 3-15%
Where does neutrophil develop
bone marrow
Neutrophil's common progenitor with monocyte
granulocyte-monocyte progenitor (GMP)
Production of neutrophil stimulated by
G-CSF
,What are the two pools of neutrophils
Mitotic (proliferating) and Storage (maturation)
What are the 5 pools of neutrophil
hematopoiesis, mitotic pool, storage pool, circulating neutrophil pool (CNP), marginated
neutrophil pool (MNP)
What is the first precursor of neutrophil
myeloblast
Myeloblast features
Type 1
-basophilic cytoplasm
- N:C 1:1
-no granules
Type 2
-azure granules
-no function
Promyelocyte features
-nucleoli easily seen
-basophilic cytoplasm with primary azuphilic granules
-"myeloperoxidase", most abundant
Neutrophil Myelocyte features
-smaller than promyelocytes
-lavender pink
, -more heterochromatin in nucleus
-nucleoli hard to see
Neutrophil Metamyelocyte features
-not capable of division
-indented nuclear with clumped chromatin (missing nucleoli)
-little residual of RNA
-bean-shaped
Neutrophil Band features
-synthesis of tertiary and secretory granules
-no basophilia, no RNA
-indented, band-shape
PMN (segmented) Neutrophil features
-synthesis of secretory granules
-3 or 4 nuclear segments connected by threadlike filaments
What are neutrophil functions
phagocytosis and destruction, form neutrophil extracellular traps (NET), secretion
What is the important of myeloperoxidase in neutrophil
produces hypohalous acids to carry out their antimicrobial activity
What is Neutrophil Extracellular Traps (NET)
-generated as neutrophils die from antibacterial activity
-chains of nucleosomes, enzymes trap and kill bacteria and fungi
What are eosophil functions (#6)
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
What is the state of the granule of neutrophils
acid and basic
What is the state of the granule of eosinophils
basic stained with eosin
What is the state of the granule of neutrophils
acidic stained with methylene blue
What is the common progenitor of neutrophil, onocyte, eosinophil, and basophil
common myeloid progenitor
Mononuclear cells include:
monocyte and lymphocyte
What are the two forms of neutrophils
Polymorphonuclear (PMN) and Band
*PMN is major form, Band only 3-15%
Where does neutrophil develop
bone marrow
Neutrophil's common progenitor with monocyte
granulocyte-monocyte progenitor (GMP)
Production of neutrophil stimulated by
G-CSF
,What are the two pools of neutrophils
Mitotic (proliferating) and Storage (maturation)
What are the 5 pools of neutrophil
hematopoiesis, mitotic pool, storage pool, circulating neutrophil pool (CNP), marginated
neutrophil pool (MNP)
What is the first precursor of neutrophil
myeloblast
Myeloblast features
Type 1
-basophilic cytoplasm
- N:C 1:1
-no granules
Type 2
-azure granules
-no function
Promyelocyte features
-nucleoli easily seen
-basophilic cytoplasm with primary azuphilic granules
-"myeloperoxidase", most abundant
Neutrophil Myelocyte features
-smaller than promyelocytes
-lavender pink
, -more heterochromatin in nucleus
-nucleoli hard to see
Neutrophil Metamyelocyte features
-not capable of division
-indented nuclear with clumped chromatin (missing nucleoli)
-little residual of RNA
-bean-shaped
Neutrophil Band features
-synthesis of tertiary and secretory granules
-no basophilia, no RNA
-indented, band-shape
PMN (segmented) Neutrophil features
-synthesis of secretory granules
-3 or 4 nuclear segments connected by threadlike filaments
What are neutrophil functions
phagocytosis and destruction, form neutrophil extracellular traps (NET), secretion
What is the important of myeloperoxidase in neutrophil
produces hypohalous acids to carry out their antimicrobial activity
What is Neutrophil Extracellular Traps (NET)
-generated as neutrophils die from antibacterial activity
-chains of nucleosomes, enzymes trap and kill bacteria and fungi
What are eosophil functions (#6)
