BLD 324 - 1 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE

BLD 324 - 1 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE red marrow produces blood cells, also called spongey bone hematopoiesis blood cell production yellow marrow stores fat mesoblastic time 19 to 20 days after gestation sinusoids -venous sinus, central empty space -provide venous drainage for marrow -cells leave marrow parenchyma via sinusoids mesoblastic location blood islands that line the yolk sac parenchyma Sinusoidal capillaries and hematopoietic cords 3 hemoglobin types produced during mesoblastic phase portland, gower 1, and gower 2 hepatic phase time from 3rd month after gestation thru 7th month hepatic phase location liver blood cell difference between mesoblastic and hepatic phase erythroblasts are primitive during the mesoblastic stage with nuclei and only the 1 developmental stage, during the hepatic phase blood cells lose the nucleus and begin expressing all developmental stages hemoglobin F fetus hemoglobin A adult hemoglobin F vs A HgbF has a greater binding affinity to O2 than HgbA medullary phase time from 5th month post-gestation and forevermore medullary phase location hematopoiesis starts happening in bone marrow, extramedullary production subsides before birth three hemoglobins detected during medullary phase HgA, HgA2, and HgF (declining) which two medullary phase Hgb have β chains HbA and HgA2 when are sickle cells visible and why at 6 months due to the effect on β chains when will hematopoiesis become extramedullary during disease active cell production sites during adulthood sternum, pelvis, ribs, vertebrae, skull, and proximal ends of long bones hematopoietic cords Clumps of differentiating blood cells central artery supplies blood for the white and red pulp endosteum membrane lining the medullary cavity of a bone adipocyte cell storing fat megakaryocyte bone marrow cell that produces and releases platelets into venous sinus, can be seen without oil immersion erythroblastic eyelet/erythrocytic island young erythrocytes surrounding macrophage, seen near sinus lining marrow egress the movement of mature cells toward the sinus and into the bloodstream what allows marrow egress matured cells lose adhesion molecule receptors and are flexible enough to squeeze through the 3-layered barrier into the venous sinus