BLD 324 FINAL EXAM QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
Which of the following is derived from the common myeloid stem cell?
Mature Erythrocytes
Select the answer that defines hematopoiesis best.
Making blood cells
The nucleus appears least active in which normoblast stage?
Orthochromic Normoblast
Select the cell that can be identified as morphologically distinct on a Wright's
stained bone marrow slide.
Pronormoblast
Which of the following is NOT a feature of a stem cell?
It is committed to making lymphocytes - not committed to anything yet
Which step in normal erythrocyte maturation requires the most time?
CFU-E to Pronormoblast
The mesoblastic Phase of Hematopoiesis occurs in the-
Yolk Sac
The BODY's iron levels are ultimately controlled by-
Activity of iron transport via the enterocyte
Which receptor converts Fe2+ to Fe3+ for iron transport in the bloodstream?
Transferrin
,Select the earliest stage of red blood cell maturation found in the peripheral blood
in a healthy adult.
Mature erythrocyte
Iron is absorbed best by which of the following dietary sources?
meat
When the level of iron in the BODY rises, which of the following will result?
Hepcidin production will increase
Which Erythrocyte Precursor is the least basophilic?
Orthochromic Normoblast
What must occur for iron to be absorbed by the enterocyte?
DVMT1 transports iron into the cell after DcytB converts it to Fe2+
Which red blood cell precursor has the darkest blue cytoplasm?
Basophilic Normoblast
The role of hepcidin is to:
Regulate the transfer of iron into the blood by enterocytes
A red cell precursor is 10-12 microns, has a low N:C ratio and a small, condensed
and pyknotic nucleus with grayish-red cytoplasm. Identify this cell.
Orthochromic Normoblast
For cell identification of RBC precursors using a Wright Stained smear, which
structure is unique to the Pronormoblast?
Nucleolus
which cytokine decreases the time it takes to produce a mature RBC
EPO
,which of the following cells are considered a RBC progenitor
BFU-E
assymetric mitosis occurs in which RBC precursor stage
orthochromic normoblast (metarubricyte)
the role of hepcidin is to
regulate the transfer of iron into the blood by enterocytes
when a cells iron levels drop, how will it respond
produce less ferritin
which characteristic of stem cells that is essential to the production of RBCs
throughout a persons lifetime
they can produce more stem cells after division
which cells is not derived from the common myeloid progenitor
B lymphocytes
the last stage in RBC development that can divide using mitosis to generate two
identical cells is
polychromic normoblast (rubricyte)
which morphologic change occurs over the course of Normoblast maturation
coarsening of nuclear chromatin
which cytokine is important in production of platelets from the megakaryoblast
Thrombopoiten (TPO)
which cytokine is required for differentiation of the hematopoietic stem cell (HSC)
FLT 3
at which normoblast stage does global chain production start
, pronormoblast
the hemoglobin molecule is composed of
four heme molecules and four globin chains
the rate limiting step in heme synthesis is control of which enzyme
aminolevulinate (ALA) synthase
which form of hemoglobin has the lowest affinity for oxygen
tense
the total iron binding capacity of the serum is an indirect measure of which
molecule
transferrin
correct steps in order from iron absorption to transport to incorporation into
heme
DMT1 transports ferrous iron into the enterocyte
ferroportin transports iron from enterocyte to plasma
transferrin picks up ferric iron
the transferrin receptor transports iron into the cell
iron is transferred to the mitochondria
transferrin
transport protein in the blood with iron attached
Transferrin receptor (TfR)
protein on the surface of cells that moves iron into cells
ferritin
storage form of iron in cells that is metabolically active
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
Which of the following is derived from the common myeloid stem cell?
Mature Erythrocytes
Select the answer that defines hematopoiesis best.
Making blood cells
The nucleus appears least active in which normoblast stage?
Orthochromic Normoblast
Select the cell that can be identified as morphologically distinct on a Wright's
stained bone marrow slide.
Pronormoblast
Which of the following is NOT a feature of a stem cell?
It is committed to making lymphocytes - not committed to anything yet
Which step in normal erythrocyte maturation requires the most time?
CFU-E to Pronormoblast
The mesoblastic Phase of Hematopoiesis occurs in the-
Yolk Sac
The BODY's iron levels are ultimately controlled by-
Activity of iron transport via the enterocyte
Which receptor converts Fe2+ to Fe3+ for iron transport in the bloodstream?
Transferrin
,Select the earliest stage of red blood cell maturation found in the peripheral blood
in a healthy adult.
Mature erythrocyte
Iron is absorbed best by which of the following dietary sources?
meat
When the level of iron in the BODY rises, which of the following will result?
Hepcidin production will increase
Which Erythrocyte Precursor is the least basophilic?
Orthochromic Normoblast
What must occur for iron to be absorbed by the enterocyte?
DVMT1 transports iron into the cell after DcytB converts it to Fe2+
Which red blood cell precursor has the darkest blue cytoplasm?
Basophilic Normoblast
The role of hepcidin is to:
Regulate the transfer of iron into the blood by enterocytes
A red cell precursor is 10-12 microns, has a low N:C ratio and a small, condensed
and pyknotic nucleus with grayish-red cytoplasm. Identify this cell.
Orthochromic Normoblast
For cell identification of RBC precursors using a Wright Stained smear, which
structure is unique to the Pronormoblast?
Nucleolus
which cytokine decreases the time it takes to produce a mature RBC
EPO
,which of the following cells are considered a RBC progenitor
BFU-E
assymetric mitosis occurs in which RBC precursor stage
orthochromic normoblast (metarubricyte)
the role of hepcidin is to
regulate the transfer of iron into the blood by enterocytes
when a cells iron levels drop, how will it respond
produce less ferritin
which characteristic of stem cells that is essential to the production of RBCs
throughout a persons lifetime
they can produce more stem cells after division
which cells is not derived from the common myeloid progenitor
B lymphocytes
the last stage in RBC development that can divide using mitosis to generate two
identical cells is
polychromic normoblast (rubricyte)
which morphologic change occurs over the course of Normoblast maturation
coarsening of nuclear chromatin
which cytokine is important in production of platelets from the megakaryoblast
Thrombopoiten (TPO)
which cytokine is required for differentiation of the hematopoietic stem cell (HSC)
FLT 3
at which normoblast stage does global chain production start
, pronormoblast
the hemoglobin molecule is composed of
four heme molecules and four globin chains
the rate limiting step in heme synthesis is control of which enzyme
aminolevulinate (ALA) synthase
which form of hemoglobin has the lowest affinity for oxygen
tense
the total iron binding capacity of the serum is an indirect measure of which
molecule
transferrin
correct steps in order from iron absorption to transport to incorporation into
heme
DMT1 transports ferrous iron into the enterocyte
ferroportin transports iron from enterocyte to plasma
transferrin picks up ferric iron
the transferrin receptor transports iron into the cell
iron is transferred to the mitochondria
transferrin
transport protein in the blood with iron attached
Transferrin receptor (TfR)
protein on the surface of cells that moves iron into cells
ferritin
storage form of iron in cells that is metabolically active
