BLD 324 EXAM 1 QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
Blood Production Includes:
renewal, proliferation, differentiation, and maturation
Mesoblastic Phase
-Primitive, begins ~19th day after fertilization
-development of primitive erythroblasts
- development of HSC
- mostly in yolk sac, little in liver
Hepatic Phase
- begins 4-5 gestational weeks and reaches peak by 3rd month
- clusters of developing erythroblasts, granulocytes, and monocytes
- HbF
- definitive hematopoiesis
- Mostly in liver, some in spleen and bone marrow
Medullary (myeloid) Phase
- begins at 5th month and bone marrow becomes the primary site by the end of 6th
month of gestation
- extramedullary hematopoiesis subsides
HbF decreases, HbA predominates
- mostly in bone marrow
,Adult hematopoietic Tissue
bone marrow
liver
spleen
lymph nodes
thymus
Function of Spleen in Hematopoiesis
sequestration of platelets and RBC
Function of Lymph Nodes in Hematopoiesis
B lymphocyte proliferation
Function of Thymus in Hematopoiesis
T Lymphocyte proliferation
Red Marrow
hematopoietically active
Yellow Marrow
hematopoietically inactive
adipocytes
composition of hematopoietic microenvironment
-extra cellular matrix: protein carbohydrate matrix
- adhesive molecules
- cytokines
Features of Stem Cells
, - self renewal
- give rise to different progeny
- reconstitute the hematopoietic system
Pluripotential Stem Cells
give rise to all the marrow cells
- early
HSC Stem Cells
- more limited by still multi potential
- give rise to myeloid and lymphoid
Committed Stem Cell
one cell line
HSC ID
CD34
Lack HLA-DR
Lack Ag associated with more differentiated cells
Myeloid Progenitor ID
CD33
CD38
Lymphoid Progenitor ID
CD10
CD38
T Lymphoid Progenitor and NK Cells ID
CD7
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
Blood Production Includes:
renewal, proliferation, differentiation, and maturation
Mesoblastic Phase
-Primitive, begins ~19th day after fertilization
-development of primitive erythroblasts
- development of HSC
- mostly in yolk sac, little in liver
Hepatic Phase
- begins 4-5 gestational weeks and reaches peak by 3rd month
- clusters of developing erythroblasts, granulocytes, and monocytes
- HbF
- definitive hematopoiesis
- Mostly in liver, some in spleen and bone marrow
Medullary (myeloid) Phase
- begins at 5th month and bone marrow becomes the primary site by the end of 6th
month of gestation
- extramedullary hematopoiesis subsides
HbF decreases, HbA predominates
- mostly in bone marrow
,Adult hematopoietic Tissue
bone marrow
liver
spleen
lymph nodes
thymus
Function of Spleen in Hematopoiesis
sequestration of platelets and RBC
Function of Lymph Nodes in Hematopoiesis
B lymphocyte proliferation
Function of Thymus in Hematopoiesis
T Lymphocyte proliferation
Red Marrow
hematopoietically active
Yellow Marrow
hematopoietically inactive
adipocytes
composition of hematopoietic microenvironment
-extra cellular matrix: protein carbohydrate matrix
- adhesive molecules
- cytokines
Features of Stem Cells
, - self renewal
- give rise to different progeny
- reconstitute the hematopoietic system
Pluripotential Stem Cells
give rise to all the marrow cells
- early
HSC Stem Cells
- more limited by still multi potential
- give rise to myeloid and lymphoid
Committed Stem Cell
one cell line
HSC ID
CD34
Lack HLA-DR
Lack Ag associated with more differentiated cells
Myeloid Progenitor ID
CD33
CD38
Lymphoid Progenitor ID
CD10
CD38
T Lymphoid Progenitor and NK Cells ID
CD7
