BLD 324 (TEST 1) EXAM QUESTIONS AND ANSWERS
WITH COMPLETE SOLUTIONS VERIFIED
What is the primary site of Hematopoiesis in the 1st month of gestation?
Mesoderm of the yold sak during the Yolk Sac Phase (aka Mesoblastic phase)
What is the primary site of Hematopoiesis in the 5th month of gestation?
In the LIver during the Hepatic Phase
What is the primary site of Hematopoiesis in the 8th month of gestation?
In the bone marrow - during the medullary phase (Myeloid)
What is cells are made during the mesoblastic phase?
Primitive erythroblasts and hematopoietic stem cells
What cells are made during the Hepatic Phase?
Clusters of developing granulocytes, erythroblasts, monocytes, and megakaryocytes
Gowar 1, Gowar 2, and Portland are made during what?
Hb produced during the yolk sac phase
What Hb are produced during the Hepatic phase?
HbF and some HbA
What Hb are produced during the medullary phase?
Decreasing levels of HbF and predominantly HbA
What is extramedullary hematopoiesis?
Any blood production occurring outside the bone marrow (or outside the medulla of the
bone).
,What cells are made during the medullary phase of hematopoiesis?
Granulocytes, monocytes and immature RBC's
What is organs and tissues are involved in hematopoiesis in adults?
Bone Marrow (primary site)
Liver
Spleen (sequestration of platelets and old RBC's)
Lymph Nodes (B lymphocyte proliferation)
Thymus (T lymphocyte proliferation)
Which bone marrow is hematopoiteically active?
Red Marrow
In adults, where is red marrow found?
Flat bones
Irregular bones
proximal ends of long bones
What is yellow marrow comprised of?
Adipocytes
Marrow Retrogression
Active Red Marrow is replaced by inactive yellow marrow
Where is red marrow found?
Hematopoietic cords
Until age 7, what is the dominant form of marrow and where is it found?
Red in all bones
What percentage of marrow in adults is red?
, 33%
What would cause an increase in red marrow in adults?
Leukemia
High Altitude
What would cause a decrease in red marrow in adults?
Aplastic Anemia
What is the function of the sinusoids (venous sinus)?
to provide drainage for the marrow
What is a sinusoid?
a small capillary that contains a discontinuous basement membrane of the enodthelial
lining (pores with no gates or doors)
List the steps of bone marrow circulation
1. Arteries enter through the bone into the marrow and bifurcate into ascending and
descending branches
2. Branches to arterioles through the marrow parenchyma and into the bone
3. Return to the marrow space and empty into the venous sinus.
4. Space between the arterioles is filled with parenchymal cells forming hematopoietic
cords
Name the three compartments of iron distribution in the body?
Functional
Transport
Storage
Components of Heme
WITH COMPLETE SOLUTIONS VERIFIED
What is the primary site of Hematopoiesis in the 1st month of gestation?
Mesoderm of the yold sak during the Yolk Sac Phase (aka Mesoblastic phase)
What is the primary site of Hematopoiesis in the 5th month of gestation?
In the LIver during the Hepatic Phase
What is the primary site of Hematopoiesis in the 8th month of gestation?
In the bone marrow - during the medullary phase (Myeloid)
What is cells are made during the mesoblastic phase?
Primitive erythroblasts and hematopoietic stem cells
What cells are made during the Hepatic Phase?
Clusters of developing granulocytes, erythroblasts, monocytes, and megakaryocytes
Gowar 1, Gowar 2, and Portland are made during what?
Hb produced during the yolk sac phase
What Hb are produced during the Hepatic phase?
HbF and some HbA
What Hb are produced during the medullary phase?
Decreasing levels of HbF and predominantly HbA
What is extramedullary hematopoiesis?
Any blood production occurring outside the bone marrow (or outside the medulla of the
bone).
,What cells are made during the medullary phase of hematopoiesis?
Granulocytes, monocytes and immature RBC's
What is organs and tissues are involved in hematopoiesis in adults?
Bone Marrow (primary site)
Liver
Spleen (sequestration of platelets and old RBC's)
Lymph Nodes (B lymphocyte proliferation)
Thymus (T lymphocyte proliferation)
Which bone marrow is hematopoiteically active?
Red Marrow
In adults, where is red marrow found?
Flat bones
Irregular bones
proximal ends of long bones
What is yellow marrow comprised of?
Adipocytes
Marrow Retrogression
Active Red Marrow is replaced by inactive yellow marrow
Where is red marrow found?
Hematopoietic cords
Until age 7, what is the dominant form of marrow and where is it found?
Red in all bones
What percentage of marrow in adults is red?
, 33%
What would cause an increase in red marrow in adults?
Leukemia
High Altitude
What would cause a decrease in red marrow in adults?
Aplastic Anemia
What is the function of the sinusoids (venous sinus)?
to provide drainage for the marrow
What is a sinusoid?
a small capillary that contains a discontinuous basement membrane of the enodthelial
lining (pores with no gates or doors)
List the steps of bone marrow circulation
1. Arteries enter through the bone into the marrow and bifurcate into ascending and
descending branches
2. Branches to arterioles through the marrow parenchyma and into the bone
3. Return to the marrow space and empty into the venous sinus.
4. Space between the arterioles is filled with parenchymal cells forming hematopoietic
cords
Name the three compartments of iron distribution in the body?
Functional
Transport
Storage
Components of Heme
