BLD 324 (TEST 2) EXAM QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
Eosinophils
Granules w/ basic proteins that stain w/acid, like eosin. 1-5%
distinct features of megakaryocytes
Polyploid
Multilobulated nucleus
Endomitosis
form of mitosis that lacks telophase (division of nucleus) and cytokinesis (division of
cytoplasm)
Platelet estimate equation
# of platelets/field x RBC count / 200RBCs/field
or
# of platelets/field x 20,000/ul
DMS
demarcation system - a series of membrane-lined channels that invade from the plasma
membrane and grow inward to subdivides the entire cytoplasm
i. Identical to megakaryocyte plasma membrane
ii. Delineates the individual platelets during thrombocytopoiesis
Thrrombocytopoiesis
Platelet shedding
,During Megakaryocyte differentiation, what drives the transformation from
proliferative phase to terminal differentiation
TPO and IL-11
When does mitosis and endomitosis occur during the formation of
megakaryoctyes
Mitosis happens during the BFU-Meg and CFU-Meg
Endomitosis happens during LD-CFU_Meg
Stages of the terminal phase of megakaryocyte development
CMP, CFU-GEMM, BFU-Meg , CFU-Meg, LD-CFU-Meg
Stages of the proliferative phase of megakaryocyte development
LD-CFU-Meg, MK-I, MK-II, MK-III
Myeloid
Megakaryocyte arises from what common progenitor
Metamyelocyte
What is the stage of neutrophils in which the nucleus is indented in a kidney bean shape
and the cytoplasm has secondary granules that are lavender in color?
Features of a MK-III stage megakaryocyte?
Markedly lobed nucleus
What is a MK-I called
megakaryoblast
What is a MK-II called
promegakaryocyte
What is a MK-III called
, megakaryocyte
Compared with ordinary platelets, what is the most different feature of stress
platelets?
Size
What is the surface-connected canalicular system of platelets?
Invaginated plasma membrane
Serotonin
Ca2+
ATP
ADP
What can be found in dense bodies of platelets?
Von Willebrand factor binds to what during platelet adhesion?
GP Ib and collagen
What is measured in lumiaggregometry?
ATP
In eicosanoid pathways of platelet activation, what causes actin contraction?
Ca2+
What is thrombocytopoiesis?
Platelet Shedding
Phospholipase A2 and C are activated by what during platelet activation?
G protein
What cell contains both acidic and basic granules
neutrophils
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
Eosinophils
Granules w/ basic proteins that stain w/acid, like eosin. 1-5%
distinct features of megakaryocytes
Polyploid
Multilobulated nucleus
Endomitosis
form of mitosis that lacks telophase (division of nucleus) and cytokinesis (division of
cytoplasm)
Platelet estimate equation
# of platelets/field x RBC count / 200RBCs/field
or
# of platelets/field x 20,000/ul
DMS
demarcation system - a series of membrane-lined channels that invade from the plasma
membrane and grow inward to subdivides the entire cytoplasm
i. Identical to megakaryocyte plasma membrane
ii. Delineates the individual platelets during thrombocytopoiesis
Thrrombocytopoiesis
Platelet shedding
,During Megakaryocyte differentiation, what drives the transformation from
proliferative phase to terminal differentiation
TPO and IL-11
When does mitosis and endomitosis occur during the formation of
megakaryoctyes
Mitosis happens during the BFU-Meg and CFU-Meg
Endomitosis happens during LD-CFU_Meg
Stages of the terminal phase of megakaryocyte development
CMP, CFU-GEMM, BFU-Meg , CFU-Meg, LD-CFU-Meg
Stages of the proliferative phase of megakaryocyte development
LD-CFU-Meg, MK-I, MK-II, MK-III
Myeloid
Megakaryocyte arises from what common progenitor
Metamyelocyte
What is the stage of neutrophils in which the nucleus is indented in a kidney bean shape
and the cytoplasm has secondary granules that are lavender in color?
Features of a MK-III stage megakaryocyte?
Markedly lobed nucleus
What is a MK-I called
megakaryoblast
What is a MK-II called
promegakaryocyte
What is a MK-III called
, megakaryocyte
Compared with ordinary platelets, what is the most different feature of stress
platelets?
Size
What is the surface-connected canalicular system of platelets?
Invaginated plasma membrane
Serotonin
Ca2+
ATP
ADP
What can be found in dense bodies of platelets?
Von Willebrand factor binds to what during platelet adhesion?
GP Ib and collagen
What is measured in lumiaggregometry?
ATP
In eicosanoid pathways of platelet activation, what causes actin contraction?
Ca2+
What is thrombocytopoiesis?
Platelet Shedding
Phospholipase A2 and C are activated by what during platelet activation?
G protein
What cell contains both acidic and basic granules
neutrophils
