BLD 324 QUIZ 6 EXAM QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
IXa
X
cofactor (VIIa)
PPL
calcium
components of the intrinsic tenase complex (complex that converts X → Xa)
X
VIIa
PPL
calcium
cofactor (TF)
components of the extrinsic tenase complex (complex that converts X → Xa)
intrinsic - subendothelial collagen is exposed and activates factor XII
extrinsic - vessel injury causes tissue factor to be released
activation of extrinsic vs intrinsic pathways
platelet adhesion
This step in primary hemostasis occurs when platelets bind to VWF that is exposed on
the subendothelial collagen. They bind via the Gp1b receptor on the platelet surface
, Xa
II
cofactor (factor V)
calcium
PPL
components of the prothrombinase complex (complex that converts II → IIa, or
prothrombin → thrombin)
thrombin (IIa)
______ acts on fibrinogen (I) and converts it to fibrin (Ia)
then fibrin monomers spontaneously polymerize to form a soft fibrin clot.
then factor XIIIa crosslinks fibrin polymers to form a stable clot
plasma (contains all the coagulation factors)
what sample is needed for coagulation testing
3 protein chains - alpha, beta, gamma
symmetrical - central E domain with two D domains
structure of fibrinogen/fibrin
XIa activates IX → IXa (intrinsic)
VIIa activates IX → IXa (extrinsic)
two ways factor IX can be activated
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
IXa
X
cofactor (VIIa)
PPL
calcium
components of the intrinsic tenase complex (complex that converts X → Xa)
X
VIIa
PPL
calcium
cofactor (TF)
components of the extrinsic tenase complex (complex that converts X → Xa)
intrinsic - subendothelial collagen is exposed and activates factor XII
extrinsic - vessel injury causes tissue factor to be released
activation of extrinsic vs intrinsic pathways
platelet adhesion
This step in primary hemostasis occurs when platelets bind to VWF that is exposed on
the subendothelial collagen. They bind via the Gp1b receptor on the platelet surface
, Xa
II
cofactor (factor V)
calcium
PPL
components of the prothrombinase complex (complex that converts II → IIa, or
prothrombin → thrombin)
thrombin (IIa)
______ acts on fibrinogen (I) and converts it to fibrin (Ia)
then fibrin monomers spontaneously polymerize to form a soft fibrin clot.
then factor XIIIa crosslinks fibrin polymers to form a stable clot
plasma (contains all the coagulation factors)
what sample is needed for coagulation testing
3 protein chains - alpha, beta, gamma
symmetrical - central E domain with two D domains
structure of fibrinogen/fibrin
XIa activates IX → IXa (intrinsic)
VIIa activates IX → IXa (extrinsic)
two ways factor IX can be activated
