BCPPS Schizophrenia | Questions with Correct
Answers of the Latest Update 2024/2025
AP effect on Mesocortical pathway - ✔✔Worsening negative symptoms
AP effect on Mesolimbic pathway - ✔✔Relief of positive symptoms
AP effect on Nigrostriatal pathway - ✔✔Development of Extrapyramidal symptoms
AP effect on Tuberoinfundibular pathway - ✔✔Increase in prolactin release
How much D2 receptor occupancy is required for clinical benefits? - ✔✔65%
How much D2 receptor occupancy leads to movement adverse effects? - ✔✔78-80%
When do withdrawal symptoms usually begin after abrupt discontinuation of
antipsychotics? - ✔✔Withdrawal symptoms usually begin 2-3 days after abrupt
discontinuance and may last up to 14 days (average incidence: 38%)
What is preferred: High vs Low potency FGA in pregnancy? - ✔✔High potency FGAs
are recommended over the use of low potency FGAs to minimize adverse effects
(anticholinergic, hypotensive, antihistaminergic)
Depot formulations should be avoided to limit long-term exposure to the fetus
, Fluphenazine decanoate - Conventional dosing method - ✔✔i. Time to reach steady
state is 4-6 weeks
ii. A significant amount of the depot injection being released early or "dose dumping"
may be responsible for the high peak in plasma concentration that occurs within the
first day of the injection
iii. Because of individual patient pharmacokinetic variability, an oral overlap period of 1-
2 weeks may be needed
Haloperidol decanoate - Conventional dosing method - ✔✔i. Time to reach steady
state is 2-4 months
ii. Oral overlap is often necessary and may result in an increase in adverse effects such
as EPS
*Loading dose method*
i. The initial dose should be reduced in the second month to avoid accumulation as
steady state is approached
ii. Oral overlap is not required
List of FGAs - ✔✔Fluphenazine
Haloperidol
Loxapine
Perphenazine
Pimozide
Chlorpromazine
Thioridazine
Thiothixene
Trifluoperazine
9 total
Answers of the Latest Update 2024/2025
AP effect on Mesocortical pathway - ✔✔Worsening negative symptoms
AP effect on Mesolimbic pathway - ✔✔Relief of positive symptoms
AP effect on Nigrostriatal pathway - ✔✔Development of Extrapyramidal symptoms
AP effect on Tuberoinfundibular pathway - ✔✔Increase in prolactin release
How much D2 receptor occupancy is required for clinical benefits? - ✔✔65%
How much D2 receptor occupancy leads to movement adverse effects? - ✔✔78-80%
When do withdrawal symptoms usually begin after abrupt discontinuation of
antipsychotics? - ✔✔Withdrawal symptoms usually begin 2-3 days after abrupt
discontinuance and may last up to 14 days (average incidence: 38%)
What is preferred: High vs Low potency FGA in pregnancy? - ✔✔High potency FGAs
are recommended over the use of low potency FGAs to minimize adverse effects
(anticholinergic, hypotensive, antihistaminergic)
Depot formulations should be avoided to limit long-term exposure to the fetus
, Fluphenazine decanoate - Conventional dosing method - ✔✔i. Time to reach steady
state is 4-6 weeks
ii. A significant amount of the depot injection being released early or "dose dumping"
may be responsible for the high peak in plasma concentration that occurs within the
first day of the injection
iii. Because of individual patient pharmacokinetic variability, an oral overlap period of 1-
2 weeks may be needed
Haloperidol decanoate - Conventional dosing method - ✔✔i. Time to reach steady
state is 2-4 months
ii. Oral overlap is often necessary and may result in an increase in adverse effects such
as EPS
*Loading dose method*
i. The initial dose should be reduced in the second month to avoid accumulation as
steady state is approached
ii. Oral overlap is not required
List of FGAs - ✔✔Fluphenazine
Haloperidol
Loxapine
Perphenazine
Pimozide
Chlorpromazine
Thioridazine
Thiothixene
Trifluoperazine
9 total
