Sirolimus can cause which of the following?
a) Pulmonary toxicity
b) Cardiomyopathy
c) Renal insufficiency
d) Liver toxicity
Give this one a try later!
, A) Pulmonary Toxicity
Sirolimus Side effects: Hyperlipidemia, headache, nausea, dizziness,
thrombocytopenia, leukopenia, peripheral edema, hypertension,
hypokalemia, increased serum creatinine, pneumonitis, and pulmonary
toxicity. Sirolimus has a lower risk of transplant-related microangiopathy,
but this risk is increased when used in combination with tacrolimus.
Which of the following statements is true about innate immunity?
a) It occurs in response to T-cell activation
b) It occurs in response to B-cell activation
c) It is a natural process that uses phagocytes that release inflammatory mediation in
response to infections or illness
d) It is a natural process that occurs primarily in the spleen
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C) It is natural process that uses phagocytes that release inflammatory
mediation in response to infections or illness
he immune system consists of innate immunity and acquired immunity. (1)
Innate immunity occurs naturally and uses phagocytes that release
inflammatory mediators and NK cells. (2) Acquired immunity is the
response of either B cells or T cells to antigens. (3) B-cell activation can be
T-cell dependent or independent.
CW presents to clinic on day +30 after allogenic transplant (matched unrelated donor)
with a rash on her arms and chest. Using the Rule of Nines, what stage is the patient?
a) Stage 0
b) Stage 1
c) Stage 2
d) Stage 1-2
,Give this one a try later!
D) Stage 1-2
Skin +1 = Maculopapular eruption over < 25% of body area
+2=Maculopapular eruption over 25%-50% of body area
+3=Generalized erythroderma +4=Generalized
erythroderma with bullous formation and often with
desquamation
Which of the following is the first step in the pathophysiological process for acute
GVHD?
a) Damage of host tissue
b) Engraftment syndrome
c) Cytokine release syndrome
d) Inflammatory effectors
Give this one a try later!
A) Damage of host tissue
GVHD occurs when T lymphocytes contained in an allogeneic
hematopoietic stem cell graft proliferate and differentiate in vivo in
response to antigens present on host tissue recognized by the graft as
foreign. Directly, and through the secretion of inflammatory cytokines
(Cooke et al., 2017), these donor T lymphocytes attack host tissues and
produce the signs and symptoms of acute GVHD.
Pathophysiology: Three phases of GVHD 1. Phase 1: Occurs prior to the
transplant when the preparative, or conditioning, regimen of
chemotherapy (with or without radiation) may damage host tissues,
including intestinal mucosa, skin, and liver, and the mucosa becomes
permeable
, LK is approximately two months status-post allogenic bone marrow transplantation
using an unrelated donor. She comes to the clinic complaining of an itchy rash on her
chest and arms. Her immunosuppression regimen is cyclosporine and mycophenolic
acid. What would be the initial treatment?
a) Admit for IV steroids
b) Check cyclosporine level
c) Use topical hydrocortisone and have her return in 3 days
d) B and C
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D) B & C
(b- Check cyclosporine level
c- Use topical hydrocortisone)
Which of the following statements by a bone marrow donor indicates the need for
further teaching?
a) "I may require a blood transfusion during the harvest"
b) "I should take a warm bath to alleviate the pain after the harvest"
c) "I will avoid performing strenuous activities for a few days"
d) "I can expect to have some bruising at the harvest sites"
Give this one a try later!
a) Pulmonary toxicity
b) Cardiomyopathy
c) Renal insufficiency
d) Liver toxicity
Give this one a try later!
, A) Pulmonary Toxicity
Sirolimus Side effects: Hyperlipidemia, headache, nausea, dizziness,
thrombocytopenia, leukopenia, peripheral edema, hypertension,
hypokalemia, increased serum creatinine, pneumonitis, and pulmonary
toxicity. Sirolimus has a lower risk of transplant-related microangiopathy,
but this risk is increased when used in combination with tacrolimus.
Which of the following statements is true about innate immunity?
a) It occurs in response to T-cell activation
b) It occurs in response to B-cell activation
c) It is a natural process that uses phagocytes that release inflammatory mediation in
response to infections or illness
d) It is a natural process that occurs primarily in the spleen
Give this one a try later!
C) It is natural process that uses phagocytes that release inflammatory
mediation in response to infections or illness
he immune system consists of innate immunity and acquired immunity. (1)
Innate immunity occurs naturally and uses phagocytes that release
inflammatory mediators and NK cells. (2) Acquired immunity is the
response of either B cells or T cells to antigens. (3) B-cell activation can be
T-cell dependent or independent.
CW presents to clinic on day +30 after allogenic transplant (matched unrelated donor)
with a rash on her arms and chest. Using the Rule of Nines, what stage is the patient?
a) Stage 0
b) Stage 1
c) Stage 2
d) Stage 1-2
,Give this one a try later!
D) Stage 1-2
Skin +1 = Maculopapular eruption over < 25% of body area
+2=Maculopapular eruption over 25%-50% of body area
+3=Generalized erythroderma +4=Generalized
erythroderma with bullous formation and often with
desquamation
Which of the following is the first step in the pathophysiological process for acute
GVHD?
a) Damage of host tissue
b) Engraftment syndrome
c) Cytokine release syndrome
d) Inflammatory effectors
Give this one a try later!
A) Damage of host tissue
GVHD occurs when T lymphocytes contained in an allogeneic
hematopoietic stem cell graft proliferate and differentiate in vivo in
response to antigens present on host tissue recognized by the graft as
foreign. Directly, and through the secretion of inflammatory cytokines
(Cooke et al., 2017), these donor T lymphocytes attack host tissues and
produce the signs and symptoms of acute GVHD.
Pathophysiology: Three phases of GVHD 1. Phase 1: Occurs prior to the
transplant when the preparative, or conditioning, regimen of
chemotherapy (with or without radiation) may damage host tissues,
including intestinal mucosa, skin, and liver, and the mucosa becomes
permeable
, LK is approximately two months status-post allogenic bone marrow transplantation
using an unrelated donor. She comes to the clinic complaining of an itchy rash on her
chest and arms. Her immunosuppression regimen is cyclosporine and mycophenolic
acid. What would be the initial treatment?
a) Admit for IV steroids
b) Check cyclosporine level
c) Use topical hydrocortisone and have her return in 3 days
d) B and C
Give this one a try later!
D) B & C
(b- Check cyclosporine level
c- Use topical hydrocortisone)
Which of the following statements by a bone marrow donor indicates the need for
further teaching?
a) "I may require a blood transfusion during the harvest"
b) "I should take a warm bath to alleviate the pain after the harvest"
c) "I will avoid performing strenuous activities for a few days"
d) "I can expect to have some bruising at the harvest sites"
Give this one a try later!
