SBB Final Exam Review | Actual Questions and
Answers
macrocomplexloflproteinslincluding:
-Rh
-RhAG
-LWl(ICAM-4)
-GPA
-GPB
-CD47l-lBandl3
90%lfromlGlycolysisl(Embden-Meyerhofflpathway)
10%lfromlpentoselphosphatelpathwayl-lATPlsourcelforlRBCs
necessaryltolmaintainlhemelironlinlferrousl(Fe2+)lstate
Deficiencylcauseslaccumulationloflmethemoglobin,lnonfunctionallfromloflHgbl-
lMethemoglobinlReductaselPathway
permitslaccumulationlofl2,3-DPGl-lLeuberinglRapaportlShunt
DEOXYGENATED
wideningloflbeta-chain
lowerlaffinitylforlO2
expelsl2,3-DPGl-l"Tenselform"loflHgb
OXYGENATEDl
beta-chainlpulledltogether
higherlaffinitylforlO2
expelsl2,3-DPGl-l"Relaxedlform"loflHgb
higherlP50lvalue
decreasedlpHl(increasedlH+lion),lacidosis
increasedl2,3-DPG
higherltemperature
highlpCO2
Seenlinlcompensatedlanemial-l"ShiftlRight"
lowerlP50lvalue
increasedlpHl(decresedlH+lion),lalkalosis
decreasedel2,3-DPG
lowerltemeratures
lowlpCO2
SeenlinlstorageloflRBCl-l"ShiftlLeft"
,Gal-GlcNAc
B1-4l-lTypel2lprecursor
Gal-GlcNAc
B1-3
Secretedl(Se,lLe)l-lTypel1lprecursor
FUT-1
Alpha-2-L-fucosyltransferase
Fuctoselalpha1-2l-lTypel2lHlantigenltranseferasel&lSugar
D-galactosaminetrasferase
N-acetylgalactosaminelalpha1-3l-lAlantigenltransferasel&lsugar
D-galacotsyltransferase
galactoselalpha1-3l-lBlantigenltransferasel&lsugar
weaklylpositivelanti-A
weaklylpositivelanti-A,Bl-lAxlsubgroup
Negativelanti-A
SecreteslAl&lHl-lAmlsubgroup
Negativelanti-A
SecreteslHlonlyl-lAellsubgroup
O>A2>B>A2B>A1>A1B>lHldeficientl-lHighestlexpressionloflH
LowestlexpressionloflH
FUT-3
Fuctoselalpha1-4l-lLewisltransferasel&lSugar
FUT-2
Fuctoselalpha1-2l-lTypel1lHlantigenltransferasel&lsugar
Anti-Lelbh=lreactslbestlwithlLebl&lHlarelonlrbc
reactslbestlwithlgrouplOlandlA2
doeslnotlreactlwithlA1l&lB
, Anti-Lelbl=lreactslindependentlyloflamountloflHlonlrbc
bestlantiseraltoluselwhenltypinglRBCl-lanti-Lelbhlvslanti-Lelbl
A1lpatients,lhavelthelleastlamountloflHl-lautoanti-H,l-HIlislmostlcommonlin...
cordlcells
reticulocyteslinlmegaloblasticlanemia
leukemial
stressedlerythropoiesisl-lElevatedlilantigenlassociatedlwith...
IGnT
addslGlcNAcltolGal
startslbranching/lmultivalentl-lIlgene
infectiouslmonol-lanti-ilassociatedlwithlwhatldisease
Mycoplasmalpneumoniaelinfectionsl
Lymphoproliferativeldisorderl(Waldenstromlmacroglobinemia)l-lautoanti-i,l-
Ilcommonlylseenlinlpatientslwith....
B3GalNAct1
missinglPlantigenl(alsolGb5l&lLKE)l-lP1Kl&lP2Kllacklwhatlgene/lantigen
A4GALT
missinglP1/PX2l&lPkl(alsolP,lGb5l&LKE)l-lpllacklwhatlgene/lantigen
Hydaitedlcyst
Birdleggs
liverlflukel-lP1lsubstancelderivedlfrom...
ParoxysamallColdlHemoglobinuria,lPCH
DonathlLandsteinerl-lautoanti-Plassociatedlwith
Enzyme=lDecreasedl-lLutheranl(E/DTT)
Enzyme=lincreasedl-lLewisl(E/DTT)
unaffectedlbylbothl-lDiegol(E/DTT)
Enzyme=ldecreased
DTT=ldecreasedl-lYtl(E/DTT)
Answers
macrocomplexloflproteinslincluding:
-Rh
-RhAG
-LWl(ICAM-4)
-GPA
-GPB
-CD47l-lBandl3
90%lfromlGlycolysisl(Embden-Meyerhofflpathway)
10%lfromlpentoselphosphatelpathwayl-lATPlsourcelforlRBCs
necessaryltolmaintainlhemelironlinlferrousl(Fe2+)lstate
Deficiencylcauseslaccumulationloflmethemoglobin,lnonfunctionallfromloflHgbl-
lMethemoglobinlReductaselPathway
permitslaccumulationlofl2,3-DPGl-lLeuberinglRapaportlShunt
DEOXYGENATED
wideningloflbeta-chain
lowerlaffinitylforlO2
expelsl2,3-DPGl-l"Tenselform"loflHgb
OXYGENATEDl
beta-chainlpulledltogether
higherlaffinitylforlO2
expelsl2,3-DPGl-l"Relaxedlform"loflHgb
higherlP50lvalue
decreasedlpHl(increasedlH+lion),lacidosis
increasedl2,3-DPG
higherltemperature
highlpCO2
Seenlinlcompensatedlanemial-l"ShiftlRight"
lowerlP50lvalue
increasedlpHl(decresedlH+lion),lalkalosis
decreasedel2,3-DPG
lowerltemeratures
lowlpCO2
SeenlinlstorageloflRBCl-l"ShiftlLeft"
,Gal-GlcNAc
B1-4l-lTypel2lprecursor
Gal-GlcNAc
B1-3
Secretedl(Se,lLe)l-lTypel1lprecursor
FUT-1
Alpha-2-L-fucosyltransferase
Fuctoselalpha1-2l-lTypel2lHlantigenltranseferasel&lSugar
D-galactosaminetrasferase
N-acetylgalactosaminelalpha1-3l-lAlantigenltransferasel&lsugar
D-galacotsyltransferase
galactoselalpha1-3l-lBlantigenltransferasel&lsugar
weaklylpositivelanti-A
weaklylpositivelanti-A,Bl-lAxlsubgroup
Negativelanti-A
SecreteslAl&lHl-lAmlsubgroup
Negativelanti-A
SecreteslHlonlyl-lAellsubgroup
O>A2>B>A2B>A1>A1B>lHldeficientl-lHighestlexpressionloflH
LowestlexpressionloflH
FUT-3
Fuctoselalpha1-4l-lLewisltransferasel&lSugar
FUT-2
Fuctoselalpha1-2l-lTypel1lHlantigenltransferasel&lsugar
Anti-Lelbh=lreactslbestlwithlLebl&lHlarelonlrbc
reactslbestlwithlgrouplOlandlA2
doeslnotlreactlwithlA1l&lB
, Anti-Lelbl=lreactslindependentlyloflamountloflHlonlrbc
bestlantiseraltoluselwhenltypinglRBCl-lanti-Lelbhlvslanti-Lelbl
A1lpatients,lhavelthelleastlamountloflHl-lautoanti-H,l-HIlislmostlcommonlin...
cordlcells
reticulocyteslinlmegaloblasticlanemia
leukemial
stressedlerythropoiesisl-lElevatedlilantigenlassociatedlwith...
IGnT
addslGlcNAcltolGal
startslbranching/lmultivalentl-lIlgene
infectiouslmonol-lanti-ilassociatedlwithlwhatldisease
Mycoplasmalpneumoniaelinfectionsl
Lymphoproliferativeldisorderl(Waldenstromlmacroglobinemia)l-lautoanti-i,l-
Ilcommonlylseenlinlpatientslwith....
B3GalNAct1
missinglPlantigenl(alsolGb5l&lLKE)l-lP1Kl&lP2Kllacklwhatlgene/lantigen
A4GALT
missinglP1/PX2l&lPkl(alsolP,lGb5l&LKE)l-lpllacklwhatlgene/lantigen
Hydaitedlcyst
Birdleggs
liverlflukel-lP1lsubstancelderivedlfrom...
ParoxysamallColdlHemoglobinuria,lPCH
DonathlLandsteinerl-lautoanti-Plassociatedlwith
Enzyme=lDecreasedl-lLutheranl(E/DTT)
Enzyme=lincreasedl-lLewisl(E/DTT)
unaffectedlbylbothl-lDiegol(E/DTT)
Enzyme=ldecreased
DTT=ldecreasedl-lYtl(E/DTT)
