VTPP 435 EXAM QUESTIONS AND ANSWERS LATEST UPDATE 100%
CORRECT A+ GRADED. Buy Quality Materials!
What stimulates Bonegrowth
Load Force
How does bone grow?
grows vertically and elongates to keep its shape
Trabecular Bone
forms a lattice calcified lattice of bone matrix
Osteoclast
-multi nucleus
-differentiate from macrophages that are derivatives of bone marrow white blood cell
-have ruffled border
Osteocyte
-most long lived cell in human body
-senses mechanical load
-located in a lacuna
-are in rings
Canaliculi
-connection from osteocyte to osteoblast and nerves and vessels
-sends info about load or force
RANK L
-created and released by osteoblasts to ramp up osteoclast activity
-binding makes osteoclasts differentiate
Osteoblast
-follow osteoclasts to make bone
-have PTH receptors
-derived from mesenchymal cells
1,25 (OH)2 Vitamin D3 Active Form
1) hydroxylated in liver to 25-(OH)2 Vitamin D
2) hydroxylated in kidney to 1,25-(OH)2 Active Form
-1 alpha hydroxylate in kidney controlled by PTH
-vitamin D acts on small intestine to absorb Ca2+ & PO43-
Parathyroid Hormone (PTH)
-activates osteoblast/osteocyte to release RANKL
-acts on intestines, kidneys and bone
Calcitonin
-peptide hormone
-made in thyroid
-inhibits osteoclast
-stimulated by increased Ca2+
Ca2+ Sensing Receptor
CORRECT A+ GRADED. Buy Quality Materials!
What stimulates Bonegrowth
Load Force
How does bone grow?
grows vertically and elongates to keep its shape
Trabecular Bone
forms a lattice calcified lattice of bone matrix
Osteoclast
-multi nucleus
-differentiate from macrophages that are derivatives of bone marrow white blood cell
-have ruffled border
Osteocyte
-most long lived cell in human body
-senses mechanical load
-located in a lacuna
-are in rings
Canaliculi
-connection from osteocyte to osteoblast and nerves and vessels
-sends info about load or force
RANK L
-created and released by osteoblasts to ramp up osteoclast activity
-binding makes osteoclasts differentiate
Osteoblast
-follow osteoclasts to make bone
-have PTH receptors
-derived from mesenchymal cells
1,25 (OH)2 Vitamin D3 Active Form
1) hydroxylated in liver to 25-(OH)2 Vitamin D
2) hydroxylated in kidney to 1,25-(OH)2 Active Form
-1 alpha hydroxylate in kidney controlled by PTH
-vitamin D acts on small intestine to absorb Ca2+ & PO43-
Parathyroid Hormone (PTH)
-activates osteoblast/osteocyte to release RANKL
-acts on intestines, kidneys and bone
Calcitonin
-peptide hormone
-made in thyroid
-inhibits osteoclast
-stimulated by increased Ca2+
Ca2+ Sensing Receptor
