VTPP 435 EXAM QUESTIONS AND ANSWERS LATEST UPDATE 100%
CORRECT A+ GRADED. Buy Quality Materials!
Osteoporosis
-high risk of fracture
-more than 1.5 million fractures/year
-reduction in bone mass & deterioration of microarchitecture
-associated with accelerated remodeling due to age
Testosterone & Estrogen effects on Bone
-less Testosterone & Estrogen increases bone resorption
-these hormones suppress RANK Ligand
Bisphosphonates
-inhibit Bone resorption
inhibit with Farnesyl synthase to prevent ruffled border formation
-this reduces osteoclast ability
Anti RANK Ligand
-or also called RANK Ligand Antibody
-prevents precursor of osteoclast from differentiating
Osteopetrosis
-increased bone mass
-osteoclast mutation prevents bone resorption
Osteoclerosis
-decreased bone mass
-osteoblast & osteocyte mutation so their function is reduced
Bone Cancer
-bone is common site for cancer metastasis
-associated with hypercalcemia, nerve compression, bone pain, and fracture
Treatments for Cancer Can Cause Osteopenia & Osteoporosis
1) all treatments cause hypogonadism
2) elevated bone turnover
3a) bone loss
3b) diminished bone quality
CORRECT A+ GRADED. Buy Quality Materials!
Osteoporosis
-high risk of fracture
-more than 1.5 million fractures/year
-reduction in bone mass & deterioration of microarchitecture
-associated with accelerated remodeling due to age
Testosterone & Estrogen effects on Bone
-less Testosterone & Estrogen increases bone resorption
-these hormones suppress RANK Ligand
Bisphosphonates
-inhibit Bone resorption
inhibit with Farnesyl synthase to prevent ruffled border formation
-this reduces osteoclast ability
Anti RANK Ligand
-or also called RANK Ligand Antibody
-prevents precursor of osteoclast from differentiating
Osteopetrosis
-increased bone mass
-osteoclast mutation prevents bone resorption
Osteoclerosis
-decreased bone mass
-osteoblast & osteocyte mutation so their function is reduced
Bone Cancer
-bone is common site for cancer metastasis
-associated with hypercalcemia, nerve compression, bone pain, and fracture
Treatments for Cancer Can Cause Osteopenia & Osteoporosis
1) all treatments cause hypogonadism
2) elevated bone turnover
3a) bone loss
3b) diminished bone quality
