VTPP 435 EXAM QUESTIONS AND ANSWERS LATEST UPDATE 100%
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Parathyroid Hormone
-comes from chief cell of parathyroid gland
-stimulated by low Ca2+ in blood
-acts on bone to release RANK L
-acts on kidneys to reabsorb more calcium
-acts on kidneys to reabsorb more Ca2+
-activates enzyme in kidney to hydroloxate Vitamin D
itamin DV
-inactive form comes from skin and diet
-acts on intestine to increase Ca2+ and PO43+ absorption
Calcitonin
-comes from clear parafollicular cells in thyroid
-stimulated by high Ca2+ in blood
-acts on osteoclasts to inhibit their action
-only has a cell receptor on osteoclasts
Osteoblasts
-build bone
-derived from mesenchymal cells
-has a Parathyroid hormone receptor on it
-line up on the osteoid
-have a high developed ER
-follows behind osteoclasts
Osteoclasts
-derived from specialized monocytic macrophages
-has a ruffled border
-has a receptor for RANK L to activate it
-uses enzymes and acid to dissolve bone -- lacunae
-moves around
Osteocytes
-located in a lacunae
-most abundant and long lived cell in human body
-branched out via canaliculi
-sense and responds to mechanical force
-sends messages to osteoblasts and osteoclasts
Bone Remodeling
1) triggered by an event that osteocytes detect
2) osteoblasts cause pre-osteoclasts to differentiate into osteoclasts via RANK Ligand
3) osteoclasts cut away until they hit an osteocyte
4) osteoblasts are recruited and proliferated by way of WNT signaling from osteoclasts
to trigger osteoblasts
WNTs Signaling
CORRECT A+ GRADED. Buy Quality Materials!
Parathyroid Hormone
-comes from chief cell of parathyroid gland
-stimulated by low Ca2+ in blood
-acts on bone to release RANK L
-acts on kidneys to reabsorb more calcium
-acts on kidneys to reabsorb more Ca2+
-activates enzyme in kidney to hydroloxate Vitamin D
itamin DV
-inactive form comes from skin and diet
-acts on intestine to increase Ca2+ and PO43+ absorption
Calcitonin
-comes from clear parafollicular cells in thyroid
-stimulated by high Ca2+ in blood
-acts on osteoclasts to inhibit their action
-only has a cell receptor on osteoclasts
Osteoblasts
-build bone
-derived from mesenchymal cells
-has a Parathyroid hormone receptor on it
-line up on the osteoid
-have a high developed ER
-follows behind osteoclasts
Osteoclasts
-derived from specialized monocytic macrophages
-has a ruffled border
-has a receptor for RANK L to activate it
-uses enzymes and acid to dissolve bone -- lacunae
-moves around
Osteocytes
-located in a lacunae
-most abundant and long lived cell in human body
-branched out via canaliculi
-sense and responds to mechanical force
-sends messages to osteoblasts and osteoclasts
Bone Remodeling
1) triggered by an event that osteocytes detect
2) osteoblasts cause pre-osteoclasts to differentiate into osteoclasts via RANK Ligand
3) osteoclasts cut away until they hit an osteocyte
4) osteoblasts are recruited and proliferated by way of WNT signaling from osteoclasts
to trigger osteoblasts
WNTs Signaling
